The most recent big one was the Mac Defender.
http://en.wikipedia.org/wiki/Mac_Defender

Apple's initial response was 'head inthe ground'.  Due to outrage they did
eventually provide a fix.

QUOTE
According to Sophos, by May 24, there had been sixty thousand calls to
AppleCare <http://en.wikipedia.org/wiki/AppleCare> technical support about
Mac Defender-related
issues,[16]<http://en.wikipedia.org/wiki/Mac_Defender#cite_note-wisniewski-apple-support-15>and
Ed Bott of
ZDNet <http://en.wikipedia.org/wiki/ZDNet> reports that the number of calls
to AppleCare increased in volume due to Mac Defender, and that a majority of
the calls now pertain to Mac
Defender.[17]<http://en.wikipedia.org/wiki/Mac_Defender#cite_note-bott-16>AppleCare
employees have been told not to assist callers in removing the
software.[18]<http://en.wikipedia.org/wiki/Mac_Defender#cite_note-cluley-malware-17>Specifically,
support employees have been told not to instruct callers on
how to use Force Quit and Activity Monitor to stop Mac Defender, as well as
not to direct callers to any discussions pertaining to the problems caused
by Mac 
Defender.[16]<http://en.wikipedia.org/wiki/Mac_Defender#cite_note-wisniewski-apple-support-15>An
anonymous AppleCare support employee said that Apple instituted the
policy in order to prevent users from relying on technical support instead
of anti-virus 
programs.[18]<http://en.wikipedia.org/wiki/Mac_Defender#cite_note-cluley-malware-17>
/QUOTE

While I don't see it in the wikipedia article, I believe that Russian law
enforcement raided a company where they provided services using this and a
variety of other programs to exploit systems and information stolen from
them.

While in this case and it's varients these are primarily trojan based, with
no enterprise monitoring or reporting capabilities you have no way of
knowing if this is in your environment or not.

On Thu, Oct 13, 2011 at 3:01 PM, David Lum <[email protected]> wrote:

> Well, we’re getting a Mac invasion here and there is zero apparent concern
> for managing these things or worrying about vulnerabilities. To get to AD
> resources they’re standing up Win7 VM’s but doing as much work as possible
> on the native MacOS.****
>
> ** **
>
> They can get to the Internet, file shares, printers, e-mail, etc on native
> Mac but I just have alarms going off in my head “unmanaged machines with no
> idea what intellectual property is on them”.****
>
> ** **
>
> Dave****
>
> ** **
>
> *From:* [email protected] [mailto:[email protected]]
> *Sent:* Thursday, October 13, 2011 2:49 PM
>
> *To:* NT System Admin Issues
> *Subject:* Re: Macs and vunerabilities****
>
> ** **
>
> I remember the big "mac virus" recently was socially engineered - but
> that's definitely the mac's biggest vulnerability. Given that mac users
> generally believe they are invulnerable, its an arguably bigger vector than
> the same one on a Windows system.****
>
> Sent from my POS BlackBerry wireless device, which may wipe itself at any
> moment****
> ------------------------------
>
> *From: *David Lum <[email protected]> ****
>
> *Date: *Thu, 13 Oct 2011 21:45:39 +0000****
>
> *To: *NT System Admin Issues<[email protected]>****
>
> *ReplyTo: *"NT System Admin Issues" <[email protected]
> >****
>
> *Subject: *Macs and vunerabilities****
>
> ** **
>
> Does anyone have a link to an article or two that shows vulnerabilities
> that have actually been exploited? Preferably not a random blog post…****
>
> *David Lum*
> Systems Engineer // NWEATM
> Office 503.548.5229 //* *Cell (voice/text) 503.267.9764****
>
> ** **
>
> ~ Finally, powerful endpoint security that ISN'T a resource hog! ~
> ~ <http://www.sunbeltsoftware.com/Business/VIPRE-Enterprise/>  ~
>
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