|
Caro Prof. Richard L Voegels
Obrigado pela an�lise dos resumos. A experi�ncia que tenho com a Luffa
operculata, bastante usada aqui na regi�o, � no tratamento das
irrita��es nasais e epistaxes que a mesma provoca, embora muitos pacientes
relatem melhora e at� cura dos sintomas. Como voc�, achei interessante os
artigos encontrados na literatura, pois achava que somente aqui no Brasil esta
subst�ncia era usada. Fico imaginando quantas plantas das nossas florestas s�o
investigadas no exterior e que, se mostrarem princ�pios ativos efetivos, ser�o
mandadas de volta na forma de car�ssimos medicamentos....
Um abra�o,
Jorge Pierre.
----- Original Message -----
Sent: Tuesday, October 10, 2000 3:18
AM
Subject: Re: [otorri.] BUCHINHA DO
NORTE
Prezado Jorge,
Muito interessante a sua mensagem a respeito da Luffa
operculata. Eu n�o sabia que haviam artigos a respeito.
Contudo se voc� observar a primeira refer�ncia que enviou, da Universidade de
Ulm na Alemanha, os autores concluem, ap�s a realiza��o de um estudo duplo
cego com quatro diferente grupos (um placebo), que n�o houve diferen�a
significante entre os quatro grupos.
No segundo artigo,
realizado em Mannheim, os autores comparam dois grupos de pacientes, o
primeiro utilizou um spray composto por Luffa operculata associado com outras
drogas (histamina, sulfa e Galphimia glauca)
e o segundo grupo utilizou spray composto por cromogilcato de
s�dio. N�o houve grupo placebo. Os autores
concluem que os dois sprays equivalem-se (estatisticamente). Estes dados n�o
permitem concluir que a Luffa operculata apresentou efeito terap�utico pois:
1. haviam outra drogas associadas a Luffa operculata 2. n�o houve um grupo
controle para compara��o.
De qualquer forma foi
bastante interessante ler os resumos destes artigos
Um abra�o
Richard L Voegels
FMUSP
Jorge Henrique Arrais de Alencar Pierre wrote:
Caros
colegas, A Luffa operculata
� usada em preparados homeop�ticos para tratamento
da rinite al�rgica e rinite sazonal nos EUA e na Alemanha !! Existe at� um
spray nasal que tem entre seus componentes, a nossa Buchinha do
Norte: 
ZICAM™ Allergy
Relief FAQ
Luffa Operculata,
Galphimia Glauca, Histaminum Hydrochloricum, and
Sulphur.
Trabalhos encontrados na
literatura:
Wiesenauer M; Gaus W; Bohnacker U;
Haussler S Endere�o: Zentrale Einrichtung Klinische Dokumentation des
Klinikums, Universitat Ulm T�tulo: Wirksamkeitsprufung von
homoopathischen Kombinationspraparaten bei Sinusitis. Ergebnisse einer
randomisierten Doppelblindstudie under Praxisbedingungen. / Efficiency of
homeopathic preparation combinations in sinusitis. Results of a randomized
double blind study with general practitioners. Fonte:
Arzneimittelforschung; 39(5):620-5, 1989 May. ISSN: 0004-4172 Pa�s
de publica��o: GERMANY Idioma: Ger Resumo: In a controlled
randomized double-blind trial carried out by 47 physicians in private
practice with totally 152 patients with sinusitis the therapeutic success of
the following homeopathic drug preparations was investigated: Group A:
combination of luffa operculata D4, kalium bicromicum D4 and cinnabaris D3.
Group B: combination of kalium bicromicum D4 and cinnabaris D3. Group C:
luffa operculata D4. Group D: placebo. Criteria for the therapeutic result
were headache, blocked nasal breathing, trigeminal tenderness, reddening and
swelling of nasal mucosa and postnasal secretion. There was no remarkable
difference in the therapeutic success among the investigated homeopathic
drug combinations nor between the active drugs and placebo. Averaged over
all four groups 81% of the patients with acute sinusitis and 67% of the
patients with chronic sinusitis recovered. In the literature comparable
therapeutic results are reported for antibiotic therapy, decongestant nose
drops and for the drainage of nasal cavities (Au)
WEISER and colleagues, Institut fur
Antihomotoxische Medizin und Grundregulationsforschung, Baden-Baden,
Mannhein, Germany compared the efficacy and tolerance of a homoeopathic
nasal spray for hay fever (seasonal allergic rhinitis) with conventional
intranasal cromolyn sodium therapy.
Methods: 146
patients with hay fever symptoms were recruited into the randomised,
double-blind trial of 42 days. The homoeopathic remedy (Luffa comp. –Heel
trade mark Nasal Spray), 0.14 ml per application, 4 times per day consisted
of a fixed combination comprised of Luffa operculata, Galphimia
glauca, histamine and sulfur. Quality of life, as measured using the
Rhinoconjunctivitis quality of Life Questionnaire (RQLQ) was the principal
outcome measure. The trial medication tolerance was measured using global
assessment, rhinoscopy, recording of adverse events and the use of vital and
laboratory parameters.
Results: The treatment showed
quick and lasting effects. This effect was independent from the
medication applied and produced an almost complete remission of hay fever
symptoms. RQLQ global scores changed significantly during the course of the
treatment, demonstrating therapeutic equivalence between the 2 forms of
treatment. There were no adverse systemic effects, although local adverse
events appeared in 3 patients.
Conclusions: The homoeopathic
nasal spray is as efficient and well tolerated as conventional therapy with
cromolyn sodium for the treatment of hay fever.
Weiser M et al. A randomized equivalence trial
comparing the efficacy and safety of Luffa comp .-Heel nasal spray with
cromolyn sodium spray in the treatment of seasonal allergic rhinitis.
Forschende Komplementaermedizin 6(3): 142-8 Jun
1999.
Sauda��es,
Jorge Pierre, Crato-CE
|
