Ovid Technologies, Inc. Email Service ------------------------------ Results: Obstetrics & Gynecology
(C) 2005 The American College of Obstetricians and Gynecologists Volume 105(4) Supplement, April 2005, p 39S Prophylactic Use of Misoprostol in the Third Stage of Labor [Papers on Current Clinical and Basic Investigation: Poster Sessions: Monday, May 9, 2005: Obstetrics] Baskett, Thomas F. MB; Persad, Vidia MB; Clough, Heidi RN; Young, David MD Dalhousie University, Halifax, Nova Scotia, Canada (Baskett) ---------------------------------------------- Outline OBJECTIVE: METHODS: RESULTS: CONCLUSIONS: OBJECTIVE: To assess the effectiveness of oral misoprostol in comparison with intravenous oxytocin in reducing bleeding during the third stage of labor. METHODS: A double-blind, randomized controlled trial comparing oral misoprostol 400 [mu]g and intravenous oxytocin 5 U, given after delivery of the anterior shoulder of the fetus, was performed. The primary outcome was a hematocrit drop greater than 10% at 24 hours postpartum. Secondary outcomes included hemoglobin drop greater than 30%, need for additional oxytocics, blood loss greater than 1,000 mL, manual removal of placenta, blood transfusion, and the adverse effects of shivering and fever. RESULTS: Results for the intravenous oxytocin (n = 311) and oral misoprostol (n = 311) groups are as follows (expressed as percentages of each group): hematocrit drop greater than 10%, 3.4% and 3.7%, respectively (P = NS); hemoglobin greater than 30%, 8.9% and 10.2%, respectively (P = NS); blood loss greater than 1,000 mL, 2.3% and 4.5%, respectively (P = NS); manual removal of placenta, 8.0% and 8.0%, respectively (P = NS); additional oxytocics, 40.5% and 51.1%, respectively (P P P CONCLUSIONS: Oral misoprostol is as effective as intravenous oxytocin in reducing loss at delivery but is associated with an increased need for additional oxytocic drugs. The adverse effects of shivering and fever were only present with misoprostol but were not clinically troublesome.Accession Number: 00006250-200504001-00088 -- This mailing list is sponsored by ACE Graphics. Visit <http://www.acegraphics.com.au> to subscribe or unsubscribe.
