Stuff happens, breakdowns, arcs, leakage, flashover, etc.
Plan on it. To avoid destroying a delicate cmos chip with a 500v transient, I suggest surrounding the 500v section with a ground trace (I assume it's not the only thing on the board). Then any leakage, breakdowns, etc are relatively benign and the circuit will recover when the conditions are corrected.

Some time ago I designed a PMT base with a s.m. resistor divider chain. To reduce electric fields (about 1kv at the photocathode) on the board, I used an 805 footprint with rounded ends (no square corners). It was probably not really needed, but the bases have never given any trouble.

Richard


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