A friend of mine passed this on today... Check it out!
Genetics of Fibromyalgia
This study is currently recruiting patients.
![]()
Purpose
The Fibromyalgia Family Study identifies and collects blood samples from families with two or more members affected with Fibromyalgia Syndrome (FMS). The primary goal of the study is to identify genes that predispose people to FMS and/or symptoms related to FMS; identifying these genes may lead to a better understanding of the disease and more effective treatments.
| Condition |
Fibromyalgia
Irritable Bowel Syndrome
Chronic Fatigue Syndrome
Depression
|
MEDLINEplus related topics: Chronic Fatigue Syndrome; Depression; Fibromyalgia; Irritable Bowel Syndrome
Study Type: Observational
Study Design: Natural History, Cross-Sectional, Convenience Sample, Retrospective Study
Official Title: Fibromyalgia Family Study Registry
Further Study Details:
FMS predominantly affects women and is characterized by chronic widespread musculoskeletal pain, fatigue, sleep disturbance, and multiple tender points on physical examination. The pathophysiological mechanisms underlying FMS are not clearly understood, but neuroendocrine factors seem to be of major importance. Studies of familial association suggest that genetic factors play a role in FMS. This study will establish patterns of genetic linkage in families with FMS.
Participating family members will undergo a brief physical exam (including tender point exam), donate a blood sample, and complete a detailed questionnaire that includes experience with pain, fatigue, depression, bowel symptoms, headache, anxiety, and physical limitations. Measurements of serum serotonin and related compounds will also be obtained. To detect genetic factors, a genome-wide linkage scan using 405 microsatellite markers will be performed.
![]()
Eligibility
Ages Eligible for Study: 12 Years and above , Genders Eligible for Study: Both
Inclusion Criteria
- Diagnosed with fibromyalgia according to the criteria of the American College of Rheumatology
- Have at least one living family member who has also been diagnosed with fibromyalgia
- No other major rheumatological disease
Expected Total Enrollment: 560
![]()
Location and Contact Information
Illinois University of Illinois at Peoria, Peoria, Illinois, United States; Recruiting
Ohio Case Western Reserve University, Cleveland, Ohio, 44109, United States; Recruiting
David Ritter 216-778-4472
[EMAIL PROTECTED] M. A. Khan, MD, Sub-Investigator
Jane M. Olson, PhD, Principal Investigator
University of Cincinnati, Cincinnati, Ohio, United States; Recruiting
Texas University of Texas Health Sciences Center, San Antonio, Texas, United States; Recruiting
Study chairs or principal investigators
Jane M. Olson, PhD, Study Chair, Case Western Reserve University
![]()
More Information
http://darwin.cwru.edu/research/ffs
Study ID Numbers NIAMS-100
Study Start Date September 1999
Record last reviewed October 2003
NLM Identifier
NCT00071162ClinicalTrials.gov processed this record on 2003-12-23 