I am not familiar with how HUBs are internally(physically) interconnected.
What I know is that pin1 is Tx+ and pin2 is TX- and pin3 is RX+ and pin6 is RX-. So at the very least the device's communication (connected to the hub using a cross-over cable) would be messed up. TX+ and TX- connected to the hub's TX+ and TX- would cause collision at least at the port where the device is connected to the hub. Not sure if this collision would be propagated across all the other ports of the hub.
