On Tue, Dec 01, 2009 at 10:03:21AM -0500, Carlos Williams wrote:
 
> CB87E778055     1337 Mon Nov 30 08:59:15  tprem...@iamghost.com
>                (connect to a.mx.premore.net[198.186.193.20]: No route to host)
>                                          b...@premore.net

Looks like more of a network issue and not postfix specific. 

Try to telnet to the remote host and see if you can connect (run a
tcpdump at the same time to see whats happening). Try simple
network diagnostics (ie. ping, traceroute etc ...).

/erol

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