i've reported the bug here,

 python 3.10 incompat, exec FAILs @ "SystemError: PY_SSIZE_T_CLEAN macro must be 
defined for '#' formats"
  https://bugs.launchpad.net/dkimpy-milter/+bug/1949520

fwiw, python 3.9 still works as expected

now to poke at it ...

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