Living-Donor Diabetes Procedure a Success

By Thomas H. Maugh II Times Staff Writer Sat Apr 30, 7:55 AM ET

Japanese researchers have for the first time cured diabetes with a
pancreatic cell transplant from a living donor, according to a report
last week in the international medical journal the Lancet.

Implants of insulin-secreting islet cells from cadaver pancreases are
an increasingly common procedure in the United States and have been
shown to provide long-lasting freedom from insulin shots. A successful
implant usually requires islet cells from at least two cadavers.

Dr. Shinichi Matsumoto and his colleagues at the Kyoto University
Hospital reasoned that islets from a living donor would be more viable
and more likely to function properly than those from a cadaver. If
that was true, then fewer cells would be required.

They tested their theory on Jan. 19, removing half the pancreas from a
56-year-old woman, harvesting the islet cells and then implanting them
into the woman's 27-year-old daughter. The daughter had required
insulin shots for 12 years, and her diabetes was very poorly controlled.

Within 22 days they weaned her off insulin shots, Matsumoto reported.
She has remained insulin-free, he said, but long-term follow-up will
be necessary. Even if she begins to require insulin shots again, the
residual islet cells should make it much easier to control blood sugar
levels, he said.

The technique could prove useful in Japan, where organ donations after
death are rare because of cultural considerations. It could also be
helpful in the United States � where it has been unsuccessfully
attempted twice � because of a continuing shortage of pancreases from
cadavers.

http://story.news.yahoo.com/news?tmpl=story&cid=2026&e=1&u=/latimests/livingdonordiabetesprocedureasuccess





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