One minute you are feeling fine. Then suddenly you are trembling,
nauseated and short of breath; your heart is racing, and your chest
hurts. You fear you are about to die. A panic attack is terrifying
experience-and one that can strike anyone at any moment. Although the
cause of panic attacks remains uncertain, new research suggests too much
carbon dioxide might be to blame.



Experimental psychiatrist Eric Griez
<http://en.scientificcommons.org/eric_griez>   and his colleagues at the
University of Maastricht <http://www.unimaas.nl/default.asp?taal=en>  
in the Netherlands asked healthy volunteers to inhale air with varying
levels of carbon dioxide. The higher the dose of carbon dioxide, the
more the participants reported feeling fear and discomfort, as well as a
fear of losing control and dying. "Metabolic distress is
unconditionally translated into a dramatic emotional distress,"
Griez says.



The research builds on Columbia University <http://www.columbia.edu>  
psychiatrist Donald Klein <http://www.cumc.columbia.edu/dept/klein> 
's "false suffocation alarm" theory, which suggest that
people have an evolved suffocation monitor sensitive to carbon dioxide
and sodium lactate levels, both of which rise in the brain during
suffocation. More than a decade ago Klein found that air enriched with
carbon dioxide induced attacks in patients with panic disorders. These
individuals have an overly sensitive monitor, he proposed, which fires
false biological alarms in the form of panic attacks. Griez's work
adds to the theory by showing that even healthy people exhibit signs of
panic in the midst of high levels of carbon dioxide.



This new work may yield clues about what causes panic attacks, which
until now has largely been a mystery. Genes may play a role, according
to family and twin studies. "It's clear that there is the
genetic component to vulnerability," says biological psychiatrist
Jordan Smoller <http://pngu.mgh.harvard.edu/faculty/smoller>   of
Harvard University <http://www.harvard.edu>  . "It's also clear
that genes don't explain all of it." For people with certain
phobias or post-traumatic stress disorder, objects that elicit fear or
remainders of traumatic events can trigger attacks. In those with other
anxiety disorders, episodes can happen without obvious cues, which make
them difficult to prevent. To add to the puzzle, panic attacks in
healthy people occur out of the blue.



Griez's research on carbon dioxide could be a step toward relief.
Experts agree that the work may lead to the development of new ways to
test anxiety medications and treatments.




Happy Learning,




Yovan P. Putra <http://primamind.blogspot.com>

www.primastudy.com <http://www.primastudy.com>







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