Agama anjing Islam yagn adalah hasil khayalanoran gArab primitif mengharamkan
khamar..
--
Web address:
http://www.sciencedaily.com/releases/2010/11/
101118124210.htm
Well-Known Molecule May Be Behind Alcohol's Benefits to Heart Health
Vessel thickening is reduced in the carotid arteries of mice fed the equivalent
of two drinks, compared to no-alcohol controls. (Credit: Image courtesy of
University of Rochester Medical Center)
ScienceDaily (Nov. 19, 2010) Many studies support the assertion that moderate
drinking is beneficial when it comes to cardiovascular health, and for the
first time scientists have discovered that a well-known molecule, called Notch,
may be behind alcohol's protective effects. Down the road, this finding could
help scientists create a new treatment for heart disease that mimics the
beneficial influence of modest alcohol consumption.
"Any understanding of a socially acceptable, modifiable activity that many
people engage in, like drinking, is useful as we continue to search for new
ways to improve health," said Eileen M. Redmond, Ph.D., lead study author and
associate professor in the Department of Surgery, Basic and Translational
Research Division, at the University of Rochester Medical Center. "If we can
figure out at the basic science level how alcohol is beneficial it wouldn't
translate to doctors prescribing people to drink, but hopefully will lead to
the development of a new therapy for the millions of people with coronary heart
disease."
Population studies looking at patterns of health and illness and associated
factors have shown that heart disease and cardiac-related death is 20 to 40
percent lower in light to moderate drinkers, compared to people who don't
drink. Redmond notes that even if the reduction is only 20 percent, that still
translates to a considerable benefit that warrants further investigation to
better understand how alcohol works its protective magic.
In the study, published in Arteriosclerosis, Thrombosis and Vascular Biology,
scientists found that alcohol at moderate levels of consumption -- generally
considered one to three drinks per day -- inhibits Notch, and subsequently
prevents the buildup of smooth muscle cells in blood vessels, which contributes
to narrowing of the arteries and can lead to a heart attack or stroke.
In trying to uncover the molecular players involved when it comes to alcohol
and improved cardiovascular health, Redmond and her team focused in on Notch
because research has shown it influences the fate -- growth, migration or death
-- of vascular smooth muscle cells. In blood vessels, the growth and movement
of smooth muscle cells plays a key role in the development of atherosclerosis,
the hardening and narrowing of arteries, and in restenosis, the re-narrowing of
arteries after they have been treated to remove buildups of plaque: Both are
risk factors for heart attack and stroke.
The team studied the effects of moderate amounts of alcohol in human coronary
artery smooth muscle cells and in the carotid arteries of mice. In both
scenarios, regular, limited amounts of alcohol decreased Notch, which in turn
decreased the production and growth of smooth muscle cells, leaving vessels
open and relatively free of blockages or build-up -- a desirable state for a
healthy heart.
Specifically, in human smooth muscle cells, treatment with moderate levels of
alcohol significantly decreased the expression of the Notch 1 receptor and
inhibited Notch signaling, leading to decreased growth of smooth muscle cells.
The inhibitory effect of moderate alcohol on smooth muscle cell growth was
reversed if the Notch pathway was artificially switched on in these cells.
In a mouse model of vessel remodeling, daily feeding of alcohol -- equivalent
to two drinks per day, adjusted for body weight -- inhibited Notch in the
vessel wall and markedly reduced vessel thickening, compared to the control, no
alcohol group. Vessel remodeling occurs when vessels change shape and thickness
in response to different injurious stimuli.
"At the molecular level, this is the first time anyone has linked the benefits
of moderate drinking on cardiovascular disease with Notch," said David Morrow,
Ph.D., an instructor in the Department of Surgery at the Medical Center, first
author of the study and an expert on Notch. "Now that we've identified Notch as
a cell signaling pathway regulated by alcohol, we're going to delve deeper into
the nuts and bolts of the process to try to find out exactly how alcohol
inhibits Notch in smooth muscle cells."
Researchers admit that uncovering how alcohol inhibits Notch signaling in these
cells will not be an easy task. According to Redmond, "The Notch pathway is
complex, and there are multiple potential regulatory points which could be
affected by alcohol."
In addition to Redmond and Morrow, co-authors on the study include John P.
Cullen, Ph.D., and Weimin Liu, M.D., Ph.D., also in the Department of Surgery,
Research Division at the University of Rochester Medical Center, and Paul A.
Cahill, Ph.D., at the Vascular Health Research Center, Dublin City University,
Ireland. The study was funded by grants from the National Institute on Alcohol
Abuse and Alcoholism at the National Institutes of Health and the American
Heart Association.
Editor's Note: This article is not intended to provide medical advice,
diagnosis or treatment.
Email or share this story:
| More
Story Source:
The above story is reprinted (with editorial adaptations by ScienceDaily
staff) from materials provided by University of Rochester Medical Center.
Journal Reference:
1. D. Morrow, J. P. Cullen, W. Liu, P. A. Cahill, E. M. Redmond. Alcohol
Inhibits Smooth Muscle Cell Proliferation via Regulation of the Notch Signaling
Pathway. Arteriosclerosis, Thrombosis, and Vascular Biology, 2010; 30 (12):
2597 DOI: 10.1161/ATVBAHA.110.215681
Need to cite this story in your essay, paper, or report? Use one of the
following formats:
APA
MLA
University of Rochester Medical Center (2010, November 19). Well-known molecule
may be behind alcohol's benefits to heart health. ScienceDaily. Retrieved
November 20, 2010, from http://www.sciencedaily.com
/releases/2010/11/101118124210.htm
Note: If no author is given, the source is cited instead.
------------------------------------
Post message: [email protected]
Subscribe : [email protected]
Unsubscribe : [email protected]
List owner : [email protected]
Homepage : http://proletar.8m.com/Yahoo! Groups Links
<*> To visit your group on the web, go to:
http://groups.yahoo.com/group/proletar/
<*> Your email settings:
Individual Email | Traditional
<*> To change settings online go to:
http://groups.yahoo.com/group/proletar/join
(Yahoo! ID required)
<*> To change settings via email:
[email protected]
[email protected]
<*> To unsubscribe from this group, send an email to:
[email protected]
<*> Your use of Yahoo! Groups is subject to:
http://docs.yahoo.com/info/terms/
