Twisted you say? Hmm. As I said, I've only just started playing around with 
wxpython recently, other than the script I linked to i'm not sure how to 
integrate them at this point. I have however managed to integrate pyglet 
with twisted before using Twisted's coiterate function, I have an exampleof 
that around if you like.

Working with OpenGL may be a bit tricky, I know of a few tools available 
that may help if your not aware of them already. There's Peter Meijers [The 
vOICe <https://www.seeingwithsound.com/winvoice.htm>] sotware, which you 
could use to scan the active window and convert it into sound. Another 
option would be the accessible paint tool [BrushTone 
<https://sysop-delco.itch.io/brushtone>], you could take a screenshot of 
the window with the print screen key, paste and save it as an image in 
something like mspaint and run it through BrushTone to look at the results.

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