Hi Titus,
I've tried out the change that you suggested for moving the storage  
initialization and strslice() code to FileSequenceDB.  I agree with  
you that all this code seems more naturally to be a part of the  
sequence database class, and I'm hoping that this will make this class  
less confusing to people.  This allowed me to get rid of  
_init_subclass from two classes (FileDBSequence and XMLRPCSequence).

I pushed this change to master; get the latest code from the public  
git repository.

One minor point: FileDBSequence.__len__() directly uses an internal  
interface (seqLenDict), which feels a little unmodular, as does the  
descriptor class used to provide the seq property on this class.

Yours,

Chris

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