On May 31, 2009, at 6:50 AM, C. Titus Brown wrote:

>
> I can't think of a reason why blastx and tblastx shouldn't be able to
> take in query databases as well as sequences, but that doesn't mean
> there isn't one ;).  Any comments?

Hi Titus,
I think this makes particular sense in light of your proposal for  
changing the behavior of BlastxMapping, to use "canonical" 6-frame  
translation annotations rather than the original way I did it  
(creating a new TranslationAnnotation for each hit, and returning a  
separate NLMSASlice for each hit).  Under your proposal, it seemed we  
would use the same set of canonical TranslationAnnotations for all  
hits to a given sequence, and thus could save them all to the same  
NLMSA.  That would make the BlastxMapping interface the same as the  
BlastMapping interface, whose __call__() returns a NLMSA object.

Shall we go ahead and make that change?  Do you want to discuss  
details of the implementation?  And who should do it?

Cheers,

-- Chris

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