On Sat, Jun 13, 2009 at 08:54:54PM -0700, Christopher Lee wrote:
-> First, I've noticed with increasing alarm that BLAST is like a black  
-> hole that will suck in more and more development effort seemingly  
-> without limit.

[ ... ]

Yup ;)

-> I would rather achieve "80% of the value for 20% of the effort" by  
-> drawing a clear line separating what we will vs will not do for BLAST,  

[ ... ]

Sounds good.

-> 1. the BLAST path whitespace bug.  The BLASTDB env variable only works  
-> for blastall, not for formatdb, so it doesn't really solve the problem  
-> for us.  So I think we should just raise a clear error message telling  
-> the user that BLAST can't handle whitespace in file paths.

+1

-> 2. handling of self-alignment in pairwise mode.  We proposed changing  
-> pairwise mode to report self-alignments, rendering obsolete the  
-> current annoying warning message.

+1, will submit patch this week.

-> 3. blastx 6 frame ORFs.  We proposed changing this so each sequence  
-> would have just 6 full-length ORFs associated with it, and therefore  
-> blastx could return a single NLMSA (containing all the results), just  
-> as the regular blastn/blastp mode does.

+1, working on details.

cheers,
--titus
-- 
C. Titus Brown, [email protected]

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