> Given this situation, I believe that despite paste making an effort to
> be multithreaded, it would still be advantageous to run a cluster of
> four Pylons instances and proxy to these using nginx.

You may consider apache with mod_wsgi, it can be simpler to manage in
such context. In particular WSGIDaemonProcess let you set the number
of dedicated processess...

-- 
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| Marcin Kasperski   | A process that is too complex will fail.
| http://mekk.waw.pl |                  (Booch)
|                    |
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