With stuff like this, you'll definitely get a productivity increase by
using nginx/lighttpd in front of Pylons -- the server on front can be
configured to pull in the entire file from the client & caching before
passing off to nginx.

Something that I would bring up though - is what are you doing with
these files ?  And have you been able to test your code to see if the
bottleneck is elsewhere ?

I can see a few issues causing this:
- KeepAlive / Persistent connection settings - are you doing an http
open/close for every file ?  that will slow stuff down
- disk io - lots of little files use more resources than fewer little
files.  your applications design/architecture might be running into
issues because of this.
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