Another non-ORM option is to use SQL Relay which has it's own python API (which 
is simple to use) and it also supports the python DB interface, if you prefer.

http://sqlrelay.sourceforge.net/

>From the SQL Relay home page:

==================================

SQL Relay is a persistent database connection pooling, proxying and load 
balancing system for Unix and Linux.


SQL Relay is ideal for:

* speeding up database-driven web-based applications

* enhancing the scalability of database-driven web-based applications 

* distributing access to replicated databases

* throttling database access

* accessing databases from unsupported platforms

* migrating applications from one database to another

====================================


I  use it on several projects and find it easy to configure/maintain and the 
performance has been solid.  

Phil

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