Assuming that "application.ini" defines all your settings for your pyramid 
app...

one way that could work for you is this....

    from paste.deploy import loadapp
    import os
    here = os.getcwd()
    app = loadapp("config:application.ini", relative_to=here)

at this point any initialization that was needed should be done. you should 
be able to do things like import your models and perform queries and such

   from myapplication.model import User, DBSession
   [u.email for u in DBSession().query(User)]

This assumes your models are defined in model.py and youre session factory 
is named DBSession

or to get your resource root assuming its defined in resource.py as Root and 
this is what's passed to the configurator as the root_factory

    from myapplication.resource import Root
    root = Root()



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