Could you use nginx + uwsgi/gunicorn/etc ?

I'm generally anti-Apache because I don't like the memory/process 
management model and miscellaneous concurrency issues ( handling the 
number, and also dealing with slow connections/hangups ).  If you ran 
mod_wsgi, I would make really suggest you either have nginx or a "Vanilla" 
apache on Port 80 that proxies to your mod_wsgi, or use Varnish as a load 
balancer.  This has nothing to do with mod_wsgi, you just absolutely need 
to keep static traffic and direct clients off of dynamic apache servers.

I have waitress serving a site in production, and it's been fine.  It's 
fronted by nginx though, which just proxies dynamic requests back to the 
waitress port.  Nginx handles all the connections and static files.

personally, I've been happiest with nginx+uwsgi.  that's my preference.

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