I don't have an exact answer, but I can give you a starting point -

It's my understanding that with the datastax driver/api, there is a large 
initial connection hit, and most people want to re-use the same same 
Session across multiple requests to minimize that.  It looks like a popular 
strategy is to use a @postfork hook to set up the connection in each worker.

Depending on how you're going to deploy (uwsgi, gunicorn, etc) there are 
slightly different strategies to initializing a session/connection pool for 
each worker.  that sort of stuff isn't really pyramid specific, so there is 
a lot of information on it.

Not an exact answer, but I was looking into this a few months ago and 
that's as far as I got.

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