On Saturday, April 28, 2018 at 5:45:23 AM UTC-4, [email protected] wrote:
>
>  I'm not sure what you mean here: "during setup" meaning when the app 
> starts, or when the request is being handled?


When the app starts, anything called in (or by something called in) your 
pyramid's app's `main()` (or the equivalent in middleware). Connecting to 
the database before a request is handled in a fork o threads will create 
and populate the connection pool with database connections -- which are not 
safe across forks or threads.  It's the most common cause of issues I've 
seen in SqlAlchemy webapps.

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