Guido van Rossum <gu...@python.org> added the comment:

Actually you can't really change typing.Callable's __args__, because it must be 
hashable, and lists aren't.

If GenericAlias doesn't cache yet, it might very well do so in the future to 
gain some speed when e.g. list[int] is used at runtime outside annotations, 
e.g. in cast(), so it will be important there too.

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Python tracker <rep...@bugs.python.org>
<https://bugs.python.org/issue42195>
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