In the "Object Lifetime" section you say "registers should be cleared upon last reference". That isn't safe, since there can be hidden dependencies on side effects of __del__, e.g.:
process_objects = create_pipeline() output_process = process_objects[-1] return output_process.wait() If the process class terminates the process in __del__ (PyQt5's QProcess does), then implicitly deleting process_objects after the second line will break the code.
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