Can you provide the contents of the ".Config" file that is built with your 
particular build solution?  There's a pretty good chance that the 
"FileNotFound" is actually mono trying to link back to Python shared libraries. 
 Though to be honest, debugging is going to be your best bet here.  You might 
try building in Xamarin or MonoDevelop on the mac, to be able to debug more 
easily.

-brad

On Jun 3, 2014, at 7:15 PM, Tribble, Brett <btrib...@ea.com> wrote:

> It has been a while since I’ve had to deal with this, but make sure that your 
> assembly is in the system path and/or pythonpath if it is not registered in 
> the GAC.
>  
> From: PythonDotNet [mailto:pythondotnet-bounces+btribble=ea....@python.org] 
> On Behalf Of Adam Klein
> Sent: Tuesday, June 03, 2014 4:02 PM
> To: pythondotnet@python.org
> Subject: [Python.NET] homebrew pythonnet, versus pip install --pre pythonnet
>  
> Hi All,
>  
> Amazing library, first of all!
>  
> I am experimenting with integrating ipython / numpy / pandas for interactive 
> data analysis with our large existing C# codebase. We are using the Anaconda 
> 2.0 release from ContinuumIO. With `pip install –pre pythonnet`, everything 
> goes as expected (great!)
>  
> However, when I build from source (in VS2013), point my PYTHONPATH to the 
> clr.pyd and Python.Runtime.dll that results from the build, and run my 
> ipython, I can do `import clr` and `ref = clr.AddReference(“assemblyname”)`, 
> but I cannot load any modules within this assembly. I get a `ImportError: No 
> module named …` Furthermore, if I try to do ref.ExportedTypes, I get a 
> `FileNotFoundException: Could not load file or assembly …` where it cannot 
> find an assembly that is referenced by the original assembly. There must be 
> some broken loading going on… Any thoughts why this might have different 
> behavior than what I install via PyPI 
> (https://pypi.python.org/pypi/pythonnet/2.0.0.dev1)? Or, hints on how to 
> debug?
>  
> Thanks!!!
>  
> --Adam
>  
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