The Duremes and Supremes are really the same tire with slightly different 
tread. 

Differences ? Sure ... the 50mm will be a bit cushier over bumps with the 
extra volume of air it can hold.  A bit heavier.  Like or dislike depends on 
the rider. 

Concerns ?   No .  Everything's apples and oranges . . . and you get to 
choose :)

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