On Thu, Feb 08, 2018 at 09:32:00AM -0700, Brent Pedersen wrote:
> I've been working more with crams lately and in some cases, it seems
> the default behavior of htslib is to automatically start downloading
> reference files locally even though I have not set REF_CACHE or
> REF_PATH. This is deep in a complex pipeline behind several layers of
> abstraction, but I think this is the default.

If you don't set them it'll automatically default to using the EBI for
REF_PATH and ~/.cache/hts-seqs (IIRC) for REF_CACHE.

If you really wish to totally disable them, keep REF_CACHE clear and
set REF_PATH to somewhere with no files, eg /foo, and it'll fail the
search.

It should then fail.

James

-- 
James Bonfield (j...@sanger.ac.uk)
The Sanger Institute, Hinxton, Cambs, CB10 1SA


-- 
 The Wellcome Sanger Institute is operated by Genome Research 
 Limited, a charity registered in England with number 1021457 and a 
 company registered in England with number 2742969, whose registered 
 office is 215 Euston Road, London, NW1 2BE. 

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