On Sat, 16 Jun 2018, Richard Durbin wrote:

Hello Shane and Rob,

I am fixing a problem with pbwt, and now I get link warnings for htslib with a 
current github install:

[Richards-MacBook-Pro:~/tmp/pbwt] rd% make
cc -g -O3 -I../htslib   pbwtMain.o pbwtCore.o pbwtSample.o pbwtIO.o pbwtMatch.o 
pbwtImpute.o pbwtPaint.o pbwtLikelihood.o pbwtMerge.o pbwtGeneticMap.o 
pbwtHtslib.o hash.o dict.o array.o utils.o -lpthread ../htslib/libhts.a -lz -lm 
-lbz2 -llzma -o pbwt
ld: warning: could not create compact unwind for _vcf_parse_format.isra.19: 
stack subq instruction is too different from dwarf stack size
ld: warning: could not create compact unwind for _cram_populate_ref: stack subq 
instruction is too different from dwarf stack size
ld: warning: could not create compact unwind for _rans_uncompress_O0: stack 
subq instruction is too different from dwarf stack size

I haven’t seen this before.  Should I just ignore these, or is there a way to 
remove them?

A web search suggests that this warning shows up when linking using real gcc (not the gcc wrapper around llvm that comes with Xcode). It looks like there are a couple of solutions:

1. Use clang instead of gcc

2. Use the -no_compact_unwind linker option. To do this with htslib, the best way would be:

./configure LDFLAGS='-Wl,-no_compact_unwind'
make

This linker option appears to be harmless when used with clang and the llvm gcc wrapper. Unfortunately I haven't been able to test real gcc yet as homebrew appears to want to build it from scratch, which takes rather a long time.

To see if you're using the real gcc, run `gcc -v`. If it says 'Apple LLVM' somewhere then it's the wrapper and not the real thing.

Rob Davies              r...@sanger.ac.uk
The Sanger Institute    http://www.sanger.ac.uk/
Hinxton, Cambs.,        Tel. +44 (1223) 834244
CB10 1SA, U.K.          Fax. +44 (1223) 494919


--
The Wellcome Sanger Institute is operated by Genome Research Limited, a charity registered in England with number 1021457 and a company registered in England with number 2742969, whose registered office is 215 Euston Road, London, NW1 2BE.
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