[ccp4bb] PhD position at IGBMC
Dear all, I’m looking for an enthusiastic PhD student to join my group at IGBMC (http://www.igbmc.fr/research/department/3/team/134/), Strasbourg, France. We are studying the structure and function of the dynein motor protein through an integrated structural biology approach combining x-ray crystallography and high-resolution cryoEM. The dynein motor is a complex and fascinating molecular machine involved in essential cellular processes like mitosis, organelle positioning and the beating of cilia (https://www.ncbi.nlm.nih.gov/pubmed/24064538). We also have started to work on the dynein motor related ribosome maturation factor Rea1 (https://www.ncbi.nlm.nih.gov/pubmed/30460895). Applicants should possess a Master’s or Bachelor’s degree in the life sciences, or a related discipline. The applicant should have experience in molecular biology as well as protein expression and purification. Experience in protein expression in yeast and/or insect cells would be considered an advantage. Training in x-ray crystallography and cryoEM will be provided. English language skills, the ability to work in a team, initiative, flexibility as well as good organizational and learning skills are required. The IGBMC (http://www.igbmc.fr/) is one of the leading biomedical research institutions in Europe and provides regular synchrotron access as well as cutting-edge cryo-EM facilities like a Titan Krios electron microscope equipped with a Cs corrector, a GIF energy filter, a phase plate and a Gatan summit K2 direct electron detector. An ion beam scanning electron microscope (cryo-FIB/SEM) and super-resolution fluorescence microscopy for cellular tomography studies are also available. Applicants should send a CV, a one-page summary of their research experience and contact details for two referees till 15th January 2019 to schmi...@igbmc.fr. The starting date is spring 2019. Selected publications: Sosnowski P, Urnavicius L, Boland A, Fagiewicz R, Busselez, Papai G & Schmidt H (2018) “The CryoEM structure of the Saccharomyces cerevisiae ribosome maturation factor Rea1.” Elife. 2018 Nov 26;7. pii: e39163. doi: 10.7554/eLife.39163. Schmidt H (2015) “Dynein motors: How AAA+ ring opening and closing coordinates microtubule binding and linker movement.” Bioessays 37: 532-543. Schmidt H, Zalyte R, Urnavicius L & Carter AP (2015) “Structure of human cytoplasmic dynein-2 primed for its power stroke.” Nature 518: 435-438. Schmidt H, Gleave ES & Carter AP (2012) “Insights into dynein motor domain function from a 3.3-Å crystal structure” Nat Struct Mol Biol. 19:492-7. To unsubscribe from the CCP4BB list, click the following link: https://www.jiscmail.ac.uk/cgi-bin/webadmin?SUBED1=CCP4BB=1
[ccp4bb] PhD positions in structural biology at the Astbury Centre, University of Leeds
Dear CCP4BB members, We invite applications for two PhD positions in structural cell biology based partly or entirely at the Astbury Centre for Structural Molecular Biology, University of Leeds: - *The structure and function of retinal photoreceptor connecting cilium proteins (**Closing date: 7th January 2019)* Defects in these proteins are associated with inherited disorders characterized by blindness and/or kidney failure. This project will investigate the structure and function of these proteins by X-ray crystallography, cryo-EM and super-resolution imaging approaches. This is a BBSRC White Rose DTP project supervised jointly between the Cockburn, Johnson and Ranson labs at the University of Leeds; please see https://www.findaphd.com/phds/project/structural-and-functional-studies-on-proteins-required-for-vision/?p59606 for more details. - *The molecular pathogenesis of KIF5A mutations (**Closing date: 21st January 2019)* The microtubule motor KIF5A is involved in long-range axonal transport. KIF5A mutations cause inherited spastic paraplegias. This project will investigate the effects of pathogenic mutations on the structure and function of KIF5A. This is an MRC DiMeN DTP project supervised jointly between the Twelvetrees and De Vos labs at the University of Sheffield and the Cockburn lab at the Univerisity of Leeds; please see https://www.findaphd.com/phds/project/mrc-dimen-doctoral-training-partnership-how-do-neurodegenerative-mutations-in-kinesin-1-alter-its-structure-motility-and-cellular-function/?p103997 for more details. Information on how to apply can be found in the links above. Please feel free to get in touch (j.j.b.cockb...@leeds.ac.uk) if you wish to discuss further or require any additional details. Kind regards, Joe -- Dr Joseph J B Cockburn Lecturer in X-ray Crystallography The Astbury Centre for Structural and Molecular Biology Faculty of Biological Sciences University of Leeds Leeds LS2 9JT UK +44 (0)113 3430758 j.j.b.cockb...@leeds.ac.uk http://www.astbury.leeds.ac.uk/people/staff/staffpage.php?StaffID=JJBC To unsubscribe from the CCP4BB list, click the following link: https://www.jiscmail.ac.uk/cgi-bin/webadmin?SUBED1=CCP4BB=1
[ccp4bb] CCP4 Study Weekend: late addition and last chance to register - Registration extended to midnight Wednesday 12th December (today)!
Just a reminder that registration will close at midnight tonight and you will miss out on one of the last few spaces at the SW for another year! This year there is a MR clinic where delegates can in advance pose their MR problems to our experts and hopefully solve them. Regards Karen McIntyre Science & Technology Facilties Council Scientific Computing Department - CCP4 RCaH 1.22 Tel +44 (0) 1235 44 5790 Fax +44 (0) 1235 56 7720 . @ccp4_mx STFC is part of UK Research and Innovation For more information visit https://stfc.ukri.org/ **Please note that I only work mornings until 1.30pm** -Original Message- From: CCP4 bulletin board [mailto:CCP4BB@JISCMAIL.AC.UK] On Behalf Of Randy Read Sent: 07 December 2018 09:02 To: ccp4bb Subject: [ccp4bb] CCP4 Study Weekend: late addition and last chance to register The CCP4 Study Weekend on "Integrated, rational molecular replacement" will be held at the East Midlands Conferenced Centre in Nottingham, from 8th to 10th January 2019. There are still some places left, but registration will close very soon, on 10th December. We're pleased to announce a late addition to the programme, which couldn't be publicised until the results of the CASP13 protein folding challenge had been announced. As you may have heard (if you read tech websites or the Guardian newspaper) the people from DeepMind have applied their deep learning algorithms to the protein folding problem and have done extremely well in folding the protein targets in CASP13. Andrew Senior, the lead of the AlphaFold team that achieved this result, will be attending the Study Weekend to speak about their algorithms and their potential applications. To see the rest of our exciting programme and to find registration information, please go to the meeting website: http://www.cvent.com/d/sgq8q6/6X . Best wishes, Isabel Usón, Ronan Keegan and Randy Read -- Randy J. Read Department of Haematology, University of Cambridge Cambridge Institute for Medical Research Tel: + 44 1223 336500 Wellcome Trust/MRC Building Fax: + 44 1223 336827 Hills RoadE-mail: rj...@cam.ac.uk Cambridge CB2 0XY, U.K. www-structmed.cimr.cam.ac.uk To unsubscribe from the CCP4BB list, click the following link: https://www.jiscmail.ac.uk/cgi-bin/webadmin?SUBED1=CCP4BB=1 To unsubscribe from the CCP4BB list, click the following link: https://www.jiscmail.ac.uk/cgi-bin/webadmin?SUBED1=CCP4BB=1
