Re: [ccp4bb] Prof. Jack Dunitz, 1923-2021

[Robert Stroud]

Thanks Aaron, a beautiful recognition of a great scientist.

Robert Stroud
str...@msg.ucsf.edu



> On Sep 14, 2021, at 10:13 AM, Aaron Finke  wrote:
> 
> Dear all,
> 
> It is with a heavy heart that I announce the passing of Prof. Jack Dunitz at 
> the age of 98. Prof. Dunitz was a giant in the development of modern 
> crystallographic methods, most notably in the determination of the crystal 
> structure of ferrocene, confirming the “sandwich complex” nature of that 
> molecule and ushering in the field of organometallic chemistry. As a 
> crystallographer, mathematician, and chemist, Prof. Dunitz effectively 
> bridged the gap between crystallography and chemistry, inspiring chemists to 
> exploit the utility of the burgeoning field of crystallography. He was a 
> professor at ETH-Zurich for over 60 years, and even after his “retirement” in 
> 1990, dedicated his life to crystallographic research.
> 
> I have many fond memories of Prof. Dunitz from my time at ETH. Even at the 
> age of 91, he still came into the office at least three times a week to 
> pursue research programs; I am told he continued to come in regularly until 
> Covid forced the campus closed. His wit and curiosity never dulled, and was 
> enamored with new technologies that enabled various new forms of 
> crystallographic research. He owned an iPad before I ever did! As a postdoc 
> doing crystallography, Prof. Dunitz enjoyed calling me into his office, 
> ostensibly to help him use some feature of CCDC Mercury, but in reality to 
> discuss some new idea he had about crystal symmetry and exploiting it to gain 
> some greater understanding of coordination complexes. He was the kind of 
> person who had forgotten more chemistry than I will ever know, and these 
> discussions were always enlightening and entertaining, mixing new theory with 
> the history of crystallography, much of which he bore witness or contributed 
> to. He will be sorely missed.
> 
> If you would like to express your condolences, please use the following email 
> address:  jack_condole...@ethz.ch 
> 
> Aaron
> --
> Aaron Finke
> Staff Scientist, MacCHESS
> Cornell University
> e-mail: af...@cornell.edu 
> 
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> 



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[ccp4bb] Prof. Jack Dunitz, 1923-2021

[Aaron Finke]

Dear all,

It is with a heavy heart that I announce the passing of Prof. Jack Dunitz at 
the age of 98. Prof. Dunitz was a giant in the development of modern 
crystallographic methods, most notably in the determination of the crystal 
structure of ferrocene, confirming the “sandwich complex” nature of that 
molecule and ushering in the field of organometallic chemistry. As a 
crystallographer, mathematician, and chemist, Prof. Dunitz effectively bridged 
the gap between crystallography and chemistry, inspiring chemists to exploit 
the utility of the burgeoning field of crystallography. He was a professor at 
ETH-Zurich for over 60 years, and even after his “retirement” in 1990, 
dedicated his life to crystallographic research.

I have many fond memories of Prof. Dunitz from my time at ETH. Even at the age 
of 91, he still came into the office at least three times a week to pursue 
research programs; I am told he continued to come in regularly until Covid 
forced the campus closed. His wit and curiosity never dulled, and was enamored 
with new technologies that enabled various new forms of crystallographic 
research. He owned an iPad before I ever did! As a postdoc doing 
crystallography, Prof. Dunitz enjoyed calling me into his office, ostensibly to 
help him use some feature of CCDC Mercury, but in reality to discuss some new 
idea he had about crystal symmetry and exploiting it to gain some greater 
understanding of coordination complexes. He was the kind of person who had 
forgotten more chemistry than I will ever know, and these discussions were 
always enlightening and entertaining, mixing new theory with the history of 
crystallography, much of which he bore witness or contributed to. He will be 
sorely missed.

If you would like to express your condolences, please use the following email 
address:  jack_condole...@ethz.ch

Aaron
--
Aaron Finke
Staff Scientist, MacCHESS
Cornell University
e-mail: af...@cornell.edu




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[ccp4bb] NIH-funded Postdoc, Membrane Protein Structural Biology, Nebraska, USA

[Alex Vecchio]

Dear ccp4 Community,

I would like to bring your attention to an NIH-funded Postdoc position in
the Vecchio Lab  at the University of Nebraska
studying membrane proteins and membrane protein assemblies using X-ray
crystallography and cryoEM. We are looking for a recent or soon-to-be
Ph.D., with experience in membrane proteins and one structural technique.
Potential exists for the candidate to *acquire cryoEM expertise* during the
postdoc training via a recently well-scored NSF fellowship.

For more information, please read our ad HERE

. To apply or for specific questions, please contact me at avecc...@unl.edu.

All the best,
Alex
---
Alex J. Vecchio, Ph.D.
*Assistant Professor*

University of Nebraska–Lincoln

Department of Biochemistry

Center for Integrated Biomolecular Communication

1901 Vine Street

N113 / N114 Beadle Center [Lab / Office]

Lincoln, NE 68588

avecc...@unl.edu

1 [402] 472-2933



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[ccp4bb] CBMS Lecture Series - 22 September 2021 - Chris Brosey

[Stojanoff, Vivian]

Please join us ………..


Center for Biomolecular Structure Lecture Series



Incorporating HT-SAXS into Structure-Driven Drug Discovery Pipelines


Chris Brosey


M.D. Anderson Cancer Center, The University of Texas


WEDNESDAY, September 22, 13:30 (EST - NY time zone)



Register in advance for this meeting:

   https://bnl.zoomgov.com/meeting/register/vJIsfu6przwpH8NymLh_TKxtg09_NaMkFFs



Abstract:

High-throughput (HT) methods for discovering single-target protein and nucleic 
acid ligands are well established and routinely utilized for drug discovery. 
Many critical biological outcomes, however, are mediated by multi-component 
assemblies and dynamic macromolecular architectures. HT approaches to assess 
and fine-tune ligand impact on such functional, dynamic systems remain 
underdeveloped. Small-angle X-ray scattering (SAXS) provides an opportunity to 
monitor changes to biomolecular architectures and assemblies under native 
solution environments, enabling chemical screening and selection for specific 
architectural states. I will discuss how we have incorporated time-resolved 
HT-SAXS into a classic fragment screening pipeline and used this approach to 
identify chemical allosteric effectors targeting functional architectures of 
mitochondrial Apoptosis-Inducing Factor (AIF)

---
Vivian Stojanoff, PhD
Education, Training, Outreach
User Program
p 1(631) 344 8375
e nsls.lifescien...@gmail.com
w https://www.bnl.gov/ps/lifesciences/

Address:
Center for Biomolecular Structure
National Synchrotron Light Source II
Building 745
Brookhaven National Laboratory
Upton NY 11973




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[ccp4bb] DLS/CCP4 data analysis workshop 2021

[David Waterman]

We are pleased to announce that the 8th joint Diamond-CCP4 Workshop on MX
data collection and structure solution is now open for applications.

Bringing together leading experts in the field of MX to teach best practice
in data collection and analysis, this course is aimed at PhD students,
postdocs and early career scientists who have a focus on structural biology.

The workshop will take place online via Zoom over the course of two full
weeks, plus a preparation day in advance of the workshop. It is essential
that applicants commit to attending the workshop in its entirety. Please
note below the workshop days and timings involved:

- Preparation day: Tuesday 23 November 2021
- Week 1: Monday 29 November to Friday 3 December 2021
- Week 2: Monday 6 December to Friday 10 December 2021
- The days will generally begin at 08:45 and will finish at 17:15 (UK time)

There is no fee to attend this online workshop, however attendance will be
subject to an application process and a letter of support from the
attendee's supervisor will be required. Both the application form and
supervisor's letter of support will need to be submitted by 17:00 (UK time)
on Friday 1 October 2021 (though see disclaimer below).

Some prior experience of crystallography and data collection is expected,
and those who already have an interesting project (crystals and possibly
previously collected datasets) will be given priority in selection.

- The course homepage: https://www.ccp4.ac.uk/schools/DLS-2021/
- Apply at the Diamond website:
https://www.diamond.ac.uk/Home/Events/2021/Diamond-CCP4-Data-Collection-and-Structure-Solution-Workshop-2021.html

*Disclaimer* Depending on the number of submissions we receive, we may need
to close applications earlier than the stated deadline to allow the
organisers time to process them. Applicants are therefore encouraged to
apply as soon as possible with all the required details requested,
including the letter of support. Incomplete applications will not be
processed.

-- David (on behalf of the organisers)



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[ccp4bb] Join the team at Einstein!

[Jeffrey B Bonanno]

Dear CCP4BB fellows:

Glycans/sugars are the third, and possibly the structurally most diverse, class 
of biopolymers (next to nucleic acids and proteins). All metazoan cells carry 
complex glycans on their cell surfaces that are essential for life. We are 
using the binding patterns of specific immunoreagents (single chain variable 
fragment antibodies, or scFvs, and nanobodies) against a class of structurally 
highly diverse glycans called heparan sulfates as a way to characterize 
('glycotype') mammalian cell types. Preliminary data suggests that this 
approach allows classification and identification of new cell types as well as 
differentiation between healthy and diseased cells. For this multidisciplinary, 
collaborative project between the labs of Drs. Steven Almo, Hannes Bülow, 
Ulrich Steidl & Deyou Zheng at the Albert Einstein College of Medicine, we are 
seeking a highly motivated postdoc who is interested in working at the 
interface of protein engineering, structural biophysics and glycan biology to 
study the logic of protein-sugar interactions of the heparan sulfate-specific 
scFvs with their sugar binding partners. Prior experience in protein structural 
biology is a plus but not required; interest in sugars and proteins is a must! 
Candidates should send their research statement, CV, and the names and contact 
information for three references to steve.almoeinsteinmed.org

Regards,
Jbb for SCA

Jeffrey B. Bonanno, Ph.D.
Department of Biochemistry
Albert Einstein College of Medicine
1300 Morris Park Avenue
Bronx, NY 10461




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Re: [ccp4bb] software DS, fconv still available ? contact?

[Manfred S. Weiss]

https://agklebe.pharmazie.uni-marburg.de/

Cheers,
Manfred

Am 14.09.2021 um 14:36 schrieb Guenter Fritz:

Dear all,

does somebody know whom to contact for the software  DSX or fconv of
the former group Klebe in Marburg?

Many thanks and best regards,

Guenter



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--
Dr. Manfred S. Weiss
Macromolecular Crystallography
Helmholtz-Zentrum Berlin
Albert-Einstein-Str. 15
D-12489 Berlin
Germany




Helmholtz-Zentrum Berlin für Materialien und Energie GmbH

Mitglied der Hermann von Helmholtz-Gemeinschaft Deutscher Forschungszentren e.V.

Aufsichtsrat: Vorsitzender Dr. Volkmar Dietz, stv. Vorsitzende Dr. Jutta 
Koch-Unterseher
Geschäftsführung: Prof. Dr. Jan Lüning (Sprecher), Prof. Dr. Bernd Rech, Thomas 
Frederking

Sitz Berlin, AG Charlottenburg, 89 HRB 5583

Postadresse:
Hahn-Meitner-Platz 1
14109 Berlin
Deutschland



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[ccp4bb] software DS, fconv still available ? contact?

[Guenter Fritz]

Dear all,

does somebody know whom to contact for the software  DSX or fconv of the 
former group Klebe in Marburg?


Many thanks and best regards,

Guenter



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[ccp4bb] Web developer position for AlphaFold DB at EMBL-EBI

[John Berrisford]

Dear CCP4BB

 

We are looking for a full-stack web developer interested in structural
biological data and predicted structures in the AlphaFold Protein Structure
Database (AlphaFold DB) to join the Velankar team at the European
Bioinformatics Institute (EMBL-EBI).

 

The successful candidate will work in a technical role as part of EMBL and
DeepMind's new partnership and will be responsible for data update, transfer
and processing, in addition to implementing API endpoints and developing
user-facing web pages.

 

The deadline for applications is 30th September 2021.

 

For more information and to apply, visit: embl.org/jobs/position/EBI01901

 

 

John Berrisford

 

--

John Berrisford

PDBe

European Bioinformatics Institute (EMBL-EBI)

European Molecular Biology Laboratory

Wellcome Trust Genome Campus

Hinxton

Cambridge CB10 1SD UK

Tel: +44 1223 492529

 

  http://www.pdbe.org

 
http://www.facebook.com/proteindatabank

  http://twitter.com/PDBeurope

 




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