[ccp4bb] hydrogens?

[Murpholino Peligro]

Hi

What is the best way to add hydrogens to a pdb file for a, probably, last
round of refinement?

Can hydrogens be added in a pH/pka-dependent manner? Something like this (
https://server.poissonboltzmann.org/) but get a pdb file ready for
phenix.refine/buster/refmac?


Thanks



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[ccp4bb] Fwd: Postdoc position in crystallography-driven drug discovery, Yue Lab at Newcastle University

[Wyatt W. Yue]

A reminder of the below postdoc position in crystallography-driven drug
discovery at Newcastle University, with deadline in a week (*Friday 18th
November*)
Best wishes

*Wyatt Yue*

Professor of Structural Biology

Biosciences Institute

Faculty of Medical Sciences

Newcastle University NE2 4HH

Group: www.staff.ncl.ac.uk/yuelab/

Profile: wyattyue.github.io


-- Forwarded message -
From: Wyatt W. Yue 
Date: Tue, 1 Nov 2022 at 18:02
Subject: Postdoc position in crystallography-driven drug discovery, Yue Lab
at Newcastle University
To: , 


Dear all


The Yue lab in Newcastle University is currently advertising one postdoc
position in x-ray crystallography, funded for two years in the first
instance, open to all UK/EU/non-EU/international applicants.



https://jobs.ncl.ac.uk/job/Newcastle-Research-AssistantAssociate/861857001/



You will be a crystallographer working closely with an industry partner
towards small molecule discovery for a rare misfolding disease. You will
carry out crystallography-based fragment screening and biophysical
validation studies to guide compound design for a metabolic enzyme.



You can find out more about our group here:
https://www.staff.ncl.ac.uk/yuelab/



Any informal enquiries you can contact: wyatt@newcastle.ac.uk



Deadline: Friday 18 November 2022. We aim to hold interviews in the week of
28 Nov - 2 Dec 2022.


*Wyatt Yue*

Professor of Structural Biology

Biosciences Institute

Faculty of Medical Sciences

Newcastle University NE2 4HH

Group: www.staff.ncl.ac.uk/yuelab/

Profile: wyattyue.github.io



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[ccp4bb] Opportunity: Senior CryoEM facility manager for the Midlands Regional CryoEM Facility at Leicester

[Videler, Tennie (Dr.)]

Senior CryoEM facility manager for the Midlands Regional CryoEM Facility at 
Leicester

We are searching for an exceptional Cryo EM  microscopist to manage the 
flourishing Midlands Regional Cryo-EM facility in the Institute for Structural 
and Chemical Biology at the University of Leicester. The facility hosts a 
Thermo Fisher Titan Krios with Falcon 3 and Gatan K3 detector with energy 
filter; a Philips CM200, 2 plunge freezing devices; carbon coat and glow 
discharger. The facility also hosts a high performance GPU computer cluster and 
storage supported by a dedicated computing facility manager. The facility is 
also supported by a grade 7 facility support specialist. The facility serves 
users from our Midlands partners and around the UK / Europe for both academic 
and industry projects.

Informal enquiries welcome: 
john.schw...@leicester.ac.uk

Location: Leicester
Vacancy terms: Full-time, fixed term contract until 31 December 2027 with 
possible extension dependent on funding
Salary details:

Grade 9 £54,949 to £71,598 per annum
Advert closes midnight on:
05 Dec 2022
https://jobs.le.ac.uk/vacancies/6244/cryo-electron-microscopy-facility-manager.html


The Leicester Institute of Structural and Chemical Biology 
(LISCB) is a cross-disciplinary entity that brings 
together internationally renowned research in structural biology, single 
molecule approaches and chemical biology at the University of Leicester into a 
single world-leading unit. The Institute takes advantage of synergies in 
research technologies and approaches to deliver major advances in both 
fundamental and translational research. The Institute provides access to 
world-class research facilities, including X-ray crystallography, biological 
NMR spectroscopy, single molecule microscopy and hosts the state-of-the-art 
Midlands cryo-EM facility.



Dr Tennie Videler

Institute Manager



Leicester Institute for Structure and Chemical Biology

Henry Wellcome Building office 025

University of Leicester | Lancaster Road | Leicester | LE1 7HB | UK



t: +44 (0)116 3736436

e:  h...@leicester.ac.uk
w: LISCB website: https://le.ac.uk/liscb

Twitter: @ LeicStructBio

 [cid:0a2eb7f4-6ba9-48e4-936e-f024377c2a03]







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[ccp4bb] Postdoc opening - DNA integrases

[Laura Spagnolo]

Dear Colleagues,

I am writing to advertise an opening for a postdoctoral position  in my group, 
to work on the structure/function study of serine integrases.
Further info can be found here: 
https://my.corehr.com/pls/uogrecruit/erq_jobspec_version_4.display_form 
(vacancy number 100388)

The deadline for applications is November 26th, 2022.

Best wishes,

Laura


Dr Laura Spagnolo
School of Molecular Biosciences
University of Glasgow, UK
https://www.gla.ac.uk/schools/molecularbiosciences/staff/lauraspagnolo/




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