[ccp4bb] Postdoc positions at Francis Crick Institute/Imperial College London

[Zhang, Xiaodong]

Postdoc positions are available in my group 
(www.imperial.ac.uk/people/xiaodong.zhang).
 We are currently seconded to the Francis Crick Institute 
(www.crick.ac.uk/research/labs/xiaodong.zhang),
 which is located a short tube-ride away. The successful candidate will join a 
multi-disciplinary team of international researchers investigating the 
structures and mechanisms of key complexes in homologous recombination and DNA 
repair. The post will mainly be located at the Francis Crick Institute but will 
also be able to work at Imperial College London, South Kensington campus. We 
employ a combination of biochemistry, biophysics, X-ray crystallography and 
cryo-electron microscopy, utilizing our state-of-the-art facilities at the 
Francis Crick Institute and Imperial College London. We are looking for 
candidates with a PhD in biochemistry, biophysics, structural biology or 
relevant discipline and have a demonstrated track record in conducting high 
quality original research. This post is funded by a Wellcome Trust Discovery 
Award and will be initially for 3 years.

Our preferred method of application is online via our website 
http://www3.imperial.ac.uk/employment (please select “Job Search” then MED04554 
into “Keywords”).  Please complete and upload an application form as directed, 
attaching a curriculum vitae, a cover letter and the name and contact details 
of two referees.  For informal enquiries please contact me directly. 
xiaodong.zh...@imperial.ac.uk or 
xiaodong.zh...@crick.ac.uk

Application deadline: June 16th 2024.

Professor Xiaodong Zhang FRS
Imperial College London
Sir Alexander Fleming Building, South Kensington, London, SW7 2AZ,
www.imperial.ac.uk/people/xiaodong.zhang
&
The Francis Crick Institute
1 Midland Road, London NW1 1AT
https://www.crick.ac.uk/research/labs/xiaodong-zhang




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[ccp4bb] postdoc position at Imperial College London

[Zhang, Xiaodong]

Dear all

There is a postdoc position available in my lab. For details and how to apply, 
please follow this link.

https://www.imperial.ac.uk/jobs/description/MED02162/research-associate-structural-biology

kind regards

Prof Xiaodong Zhang, Section of Structural Biology, Department of Infectious 
Disease, Imperial College London
Room 104, Sir Alexander Fleming Building, South Kensington, SW7 2AZ
xiaodong.zh...@imperial.ac.uk, (0) 207 
594 3151, http://www.imperial.ac.uk/people/xiaodong.zhang

PA - Ms Kasia Pearce, 
structuralbiolog...@imperial.ac.uk, 
(0) 207 594 2917





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[ccp4bb] Postdoc position at Imperial College London

[Zhang, Xiaodong]

Dear all,

There is a postdoc position available in my group 
(https://www.imperial.ac.uk/people/xiaodong.zhang). The successful candidate 
will join a multi-disciplinary team of international researchers investigating 
the structures and mechanisms of key components involved in eukaryotic DNA 
damage signalling and repair. We employ a combination of cryo electron 
microscopy, X-ray crystallography, biochemical and biophysical techniques, 
utilising our excellent structural biology facilities at Imperial College 
London.

Details about this post and how to apply can be found 
http://www.imperial.ac.uk/jobs/description/MED02162/research-associate-structural-biology

For informal enquiries, please email me directly with your CV.

with best wishes

Xiaodong

Professor Xiaodong Zhang
Section of Structural Biology, Department of Infectious Diseases, Imperial 
College London
104, Sir Alexander Fleming Building, South Kensington, London, SW7 2AZ, +44 207 
594 3151, PA: Ms. Kasia Pearce 
(k.pea...@imperial.ac.uk). 0207 594 2763
www.imperial.ac.uk/people/xiaodong.zhang






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[ccp4bb] Application Deadline Tomorrow - Postdoc Position at Imperial College London

[Zhang, Xiaodong]

Dear all,

We invite enthusiastic individuals to apply for a Research Association position 
in the group of Xiaodong Zhang 
(https://www.structurebiomed.org), within the 
Section of Structural 
Biology,
 Department of Medicine, at Imperial College London’s South Kensington Campus.

The successful candidate will join a multi-disciplinary team of international 
researchers investigating the structures and mechanisms of bacterial 
transcription regulation and signal transduction by AAA ATPases. We employ a 
combination of Biochemistry, cryo electron microscopy and X-ray 
crystallography, utilizing our excellent protein production and structural 
biology facilities at Imperial.

We welcome individuals with a PhD (or about to obtain one) in structural 
biology, biochemistry or biophysics with a strong interest in 
inter-disciplinary structural molecular biology research.

The post is full-time for up to 48 months.

Application deadline: July 3rd, 2018

For details and application procedure, please visit 
https://www.imperial.ac.uk/jobs/description/MED00558/research-associate

 For informal enquiries, please contact: 
xiaodong.zh...@imperial.ac.uk

Prof Xiaodong Zhang
Section of Structural Biology
Department of Medicine
Imperial College London

Room 104, Sir Alexander Fleming Building
South Kensington, SW7 2AZ
xiaodong.zh...@imperial.ac.uk
http://www.imperial.ac.uk/people/xiaodong.zhang
(0) 207 594 3151

PA - Ms Sorina Damsa, structuralbiolog...@imperial.ac.uk, (0) 207 594 2917




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[ccp4bb] Postdoc Position at Imperial College London

[Zhang, Xiaodong]

Dear all,

We invite enthusiastic individuals to apply for a Research Association position 
in the group of Xiaodong Zhang (https://www.structurebiomed.org), within the 
Section of Structural 
Biology,
 Department of Medicine, at Imperial College London’s South Kensington Campus.

The successful candidate will join a multi-disciplinary team of international 
researchers investigating the structures and mechanisms of bacterial 
transcription regulation and signal transduction by AAA ATPases. We employ a 
combination of Biochemistry, cryo electron microscopy and X-ray 
crystallography, utilizing our excellent protein production and structural 
biology facilities at Imperial.

We welcome individuals with a PhD (or about to obtain one) in structural 
biology, biochemistry or biophysics with a strong interest in 
inter-disciplinary structural molecular biology research.

The post is full-time, fixed-term until 30 September 2022.

Application deadline: July 2nd, 2018

For details and application procedure, please visit 
https://www.imperial.ac.uk/jobs/description/MED00558/research-associate

 For informal enquiries, please contact: 
xiaodong.zh...@imperial.ac.uk

Prof Xiaodong Zhang
Section of Structural Biology
Department of Medicine
Imperial College London

Room 104, Sir Alexander Fleming Building
South Kensington, SW7 2AZ
xiaodong.zh...@imperial.ac.uk
http://www.imperial.ac.uk/people/xiaodong.zhang
(0) 207 594 3151

PA - Ms Sorina Damsa, structuralbiolog...@imperial.ac.uk, (0) 207 594 2917




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[ccp4bb] Facility Manager position - London - Deadline Approaching

[Zhang, Xiaodong]

The Section of Structural Biology within the Department of Medicine along with 
its partners (The London Consortium for cryo-EM) is seeking to recruit a 
Facility Manager for a new high resolution Electron Microscopy Facility.
Imperial College London, in partnership with the Institute of Cancer Research, 
King’s College London, and Queen Mary - University of London, has been awarded 
funding by the Wellcome Trust to establish a new Electron Microscopy Facility 
to be hosted by the Francis Crick Institute near King’s Cross, which has 
already established its own cryo-EM facility.  The new Facility will include a 
FEI Titan Krios cryo electron microscope equipped with a Volta phase plate, a 
Falcoln III detector and a Gatan Bioquantum energy filter and K3 detector. It 
will offer state of the art electron cryo-microscopy for high-resolution 
structural determination.
The post holder will be responsible for the day-to-day running and management 
of the new Facility. This will include helping users access the facility for 
data collection, advising users on sample preparation and quality and helping 
manage time allocation within the consortium. The Facility Manager will ensure 
that all users receive adequate training, comply with all health and safety 
requirements, and provide assistance with the development of research projects 
and analysis of results.
This exciting and challenging post requires a strong and diverse skill set.  In 
depth knowledge and practical experience of high resolution electron 
cryo-microscopy single particle analysis and/or electron cryo-tomography as 
applied to biological systems is essential. In addition, given the 
collaborative nature of the project, you will need the ability to develop 
effective working relationships with colleagues at all levels across different 
institutions and therefore have strong communication skills.  Organisation 
skills, and the ability to work efficiently and accurately under pressure are 
also essential.
The Department has an established culture of supporting and developing staff. 
You will be rewarded with generous benefits and strong career prospects within 
well-defined and achievable career paths. For an informal discussion please 
contact Prof. Xiaodong Zhang: 
xiaodong.zh...@imperial.ac.uk
Closing date: Tuesday 20th June 2017

How to apply:

Our preferred method of application is online. Please go to 
https://www.imperial.ac.uk/job-applicants/

 Type HM2019094 in Keywords for details and applications.

Alternatively, if you are unable to apply online, please email 
f.wh...@imperial.ac.uk to request an application 
form.













Prof Xiaodong Zhang
Section of Structural Biology
Department of Medicine
Imperial College London

Room 104, Sir Alexander Fleming Building
South Kensington, SW7 2AZ
xiaodong.zh...@imperial.ac.uk
http://www.imperial.ac.uk/people/xiaodong.zhang
(0) 207 594 3151

PA - Miss Sorina Damsa, s.da...@imperial.ac.uk, (0) 207 594 2763

[ccp4bb] EM Facility Manager position - London

[Zhang, Xiaodong]

The Section of Structural Biology within the Department of Medicine along with 
its partners (The London Consortium for cryo-EM) is seeking to recruit a 
Facility Manager for a new high resolution Electron Microscopy Facility.
Imperial College London, in partnership with the Institute of Cancer Research, 
King’s College London, and Queen Mary - University of London, has been awarded 
funding by the Wellcome Trust to establish a new Electron Microscopy Facility 
to be hosted by the Francis Crick Institute near King’s Cross, which has 
already established its own cryo-EM facility.  The new Facility will include a 
FEI Titan Krios cryo electron microscope equipped with a Volta phase plate, a 
Falcoln III detector and a Gatan Bioquantum energy filter and K3 detector. It 
will offer state of the art electron cryo-microscopy for high-resolution 
structural determination.
The post holder will be responsible for the day-to-day running and management 
of the new Facility. This will include helping users access the facility for 
data collection, advising users on sample preparation and quality and helping 
manage time allocation within the consortium. The Facility Manager will ensure 
that all users receive adequate training, comply with all health and safety 
requirements, and provide assistance with the development of research projects 
and analysis of results.
This exciting and challenging post requires a strong and diverse skill set.  In 
depth knowledge and practical experience of high resolution electron 
cryo-microscopy single particle analysis and/or electron cryo-tomography as 
applied to biological systems is essential. In addition, given the 
collaborative nature of the project, you will need the ability to develop 
effective working relationships with colleagues at all levels across different 
institutions and therefore have strong communication skills.  Organisation 
skills, and the ability to work efficiently and accurately under pressure are 
also essential.
The Department has an established culture of supporting and developing staff. 
You will be rewarded with generous benefits and strong career prospects within 
well-defined and achievable career paths. For an informal discussion please 
contact Prof. Xiaodong Zhang: 
xiaodong.zh...@imperial.ac.uk
Closing date: Tuesday 20th June 2017

How to apply:

Our preferred method of application is online via this website. Please go to 
https://www.imperial.ac.uk/job-applicants/

 Type HM2019094 in Keywords for details and applications.

Alternatively, if you are unable to apply online, please email 
f.wh...@imperial.ac.uk to request an application 
form.












Prof Xiaodong Zhang
Section of Structural Biology
Department of Medicine
Imperial College London

Room 104, Sir Alexander Fleming Building
South Kensington, SW7 2AZ
xiaodong.zh...@imperial.ac.uk
http://www.imperial.ac.uk/people/xiaodong.zhang
(0) 207 594 3151

PA - Miss Sorina Damsa, s.da...@imperial.ac.uk, (0) 207 594 2763

[ccp4bb] Postdoc positions at Imperial College London

[Zhang, Xiaodong]

Salary range: £33,410 - £36,130 per annum
Full-time, fixed term for two years
South Kensington Campus

We wish to recruit two Research Associates to work in the research group of 
Professor Xiaodong Zhang (www.msf.bio.ic.ac.ukhttp://www.msf.bio.ic.ac.uk/), 
in the Section of Structural Biology, Department of Medicine, at Imperial 
College London’s South Kensington Campus. The successful candidate will join a 
multi-disciplinary team of international researchers investigating the 
structures and mechanisms of large key complexes in DNA damage response and 
repair. We employ a combination of Biochemistry, X-ray crystallography and 
cryo-electron microscopy techniques, utilising our excellent protein production 
and structural biology facilities at Imperial.
You must hold a PhD, or equivalent, in biochemistry, structural biology or 
relevant discipline and have a demonstrated track record in conducting high 
quality original research. Knowledge to at least advanced undergraduate level 
in protein biochemistry and structural biology is essential and experience in 
protein expression and purification, especially in baculovirus, is desirable.

For informal enquiries please contact Professor Xiaodong Zhang 
xiaodong.zh...@imperial.ac.ukmailto:xiaodong.zh...@imperial.ac.uk.

Our preferred method of application is online via 
https://www.imperial.ac.uk/job-applicants/ using reference HM2015132

Please download the application form and save to your computer. Once completed, 
please upload your application form prior to submitting your application.

Please note that CVs should be submitted and must be accompanied by an 
application form.


Professor Xiaodong Zhang
Section of Structural Biology
Department of Medicine
Imperial College London

504, Sir Ernst Chain Building, South Kensington, London, SW7 2AZ
Tel: (0) 207 594 3151
Email: xiaodong.zh...@imperial.ac.ukmailto:xiaodong.zh...@imperial.ac.uk
http://www.imperial.ac.uk/people/xiaodong.zhang

PA: Kasia Pearce (k.pea...@imperial.ac.uk), (0)207 594 2763

[ccp4bb] Research Associate at Imperial College London

[Zhang, Xiaodong]

We wish to recruit a Research Associate to work in the research group of 
Professor Xiaodong Zhang (www.msf.bio.ic.ac.ukhttp://www.msf.bio.ac.uk), in 
the Section of Structural Biology, Department of Medicine, at Imperial College 
London’s South Kensington Campus. The successful candidate will join a 
multi-disciplinary team of international researchers investigating the 
structures and mechanisms of large key complexes in DNA damage response and 
repair. We employ a combination of X-ray crystallography and cryo-electron 
microscopy techniques, utilising our excellent structural biology facilities at 
Imperial.
You must hold a PhD, or equivalent, in biochemistry, structural biology or 
relevant discipline and have a demonstrated track record in conducting high 
quality original research.
For informal enquiries please contact Professor Xiaodong Zhang 
xiaodong.zh...@imperial.ac.ukmailto:xiaodong.zh...@imperial.ac.uk.
Our preferred method of application is online via our website at 
http://www3.imperial.ac.uk/employment (please select “Job Search” then enter 
the vacancy reference number HM2014190 into “Keywords”). Please complete and 
upload an application form as directed quoting reference number HM2014190.
Alternatively, if you are unable to apply online, please email 
hmr...@imperial.ac.ukmailto:hmr...@imperial.ac.uk to request an application 
form.
 The Closing date is 17 November, 2014

Professor Xiaodong Zhang
Section of Structural Biology
Department of Medicine
Imperial College London
504, Sir Ernst Chain Building
South Kensington, London, SW7 2AZ
(0) 207 594 3151
xiaodong.zh...@imperial.ac.ukmailto:xiaodong.zh...@imperial.ac.uk
http://www.imperial.ac.uk/people/xiaodong.zhang

[ccp4bb] Postdoc positions in X-ray crystallography or electron microscopy at Imperial College London

[Zhang, Xiaodong]

Research Associate: London, United Kingdom
Imperial College London

Salary: £32,100 - £40,720 per annum
We are seeking two Research Associates to work in the research group of 
Professor Xiaodong Zhang (www.msf.bio.ac.ukhttp://www.msf.bio.ac.uk) in the 
Centre for Structural Biology, at the South Kensington Campus of Imperial 
College London. Funded by a Wellcome Trust Senior Investigator Award to 
Xiaodong Zhang, you will join a group of multi-disciplinary colleagues and 
collaborators to investigate the structures and mechanisms of DNA damage 
response.
These fixed-term posts are available for up to five years.
You must hold a PhD in a structural biology or biochemistry discipline or a 
related discipline, or an equivalent level of professional qualifications and 
experience. Research experience in a structural biological laboratory 
environment (covering either X-ray crystallography, or electron microscopy 
single particle analysis), and knowledge of protein biochemistry are essential.
For informal enquiries please contact Professor Xiaodong Zhang 
xiaodong.zh...@imperial.ac.ukmailto:xiaodong.zh...@imperial.ac.uk.
Our preferred method of application is online via our website 
http://www3.imperial.ac.uk/employment (please select “Job Search” then enter 
the job title or vacancy reference – NS 2012 163 IL - number including spaces 
into “Keywords”).  Please complete and upload an application form as directed.
Closing Date: 4 September 2012 (Midnight BST)



Professor Xiaodong Zhang
Imperial College London
Division of Molecular Biosciences
504, Wolfson laboratories
South Kensington, London, SW7 2AZ
(0) 207 594 3151
xiaodong.zh...@imperial.ac.ukmailto:xiaodong.zh...@imperial.ac.uk
http://www.imperial.ac.uk/people/xiaodong.zhang

[ccp4bb] Postdoc positions at Imperial College London

[Zhang, Xiaodong]

We wish to recruit two Research Associates to work in the research teams of 
Professor Xiaodong Zhang and Professor Paul Freemont 
(www.msf.bio.ac.ukhttp://www.msf.bio.ac.uk/), in the Division of Molecular 
Biosciences, Centre for Structural Biology, at the South Kensington Campus of 
Imperial College London. Our research groups comprise research fellows, 
research associates and PhD students from a diverse range of background from 
molecular biology, biochemistry, X-ray crystallography, electron microscopy, to 
chemistry, physics and engineering. We employ a multi-disciplinary approach to 
study the structures and mechanisms of large macromolecular complexes.

Post 1: Structural and mechanistic studies of p97 and cofactors – NS2011 242 KT
The multifunctional AAA ATPase p97 is involved in a myriad of cellular 
processes including cell cycle regulation, membrane traffic, protein quality 
control, DNA metabolism, signalling and apoptosis. Consequently mutations in 
p97 cause cell deaths or various disease.  Furthermore, p97 has been shown to 
be a potential target for cancer treatment. We are currently conducting an 
exciting and comprehensive study on the structure and mechanism of the p97 and 
cofactor proteins using a combination of protein biochemistry, X-ray 
crystallography and electron microscopy techniques. The successful candidates 
will be responsible for carrying out structural and functional studies of the 
p97 and its cofactors, using X-ray crystallography, NMR and electron microscopy.

Post 2: Structural studies of Chromatin Remodelling Complexes – NS2011 187 KT
Eukaryotic genomic DNA is organized into nucleosomes and chromatin for genome 
stability and integrity. However, this creates barriers for processes that 
require access to the DNA, such as transcription and DNA repair.  Chromatin 
remodeling complexes remodel nucleosomes and chromatin to provide access.  The 
INO80 complex is a multi-subunit, large macromolecular machine that remodels 
nucleosomes upon DNA damage in order for the repair machinery to access the 
damaged DNA. We are currently conducting an exciting and comprehensive study on 
the structure and mechanism of the INO80 complex using a combination of protein 
biochemistry, X-ray crystallography and electron microscopy techniques. The 
successful candidate will be responsible for carrying out structural studies of 
the INO80 complex, primarily using electron microscopy techniques. The 
successful candidate will work closely with Prof. Wigley’s laboratory at the 
Institute of Cancer Research, Chester Beatty Laboratories where the majority of 
the protein biochemistry will be carried out.
Successful candidates must hold a PhD in a structural biology or biochemistry 
discipline and have demonstrated an ability to carry out high quality original 
research using electron microscopy or X-ray crystallography techniques.

Closing date – Feb 29th, 2012

Our preferred method of application is online via our website 
http://www3.imperial.ac.uk/employment (please select “Job Search” then enter 
the job title or vacancy reference number including spaces into “Keywords”).  
Please complete and upload an application form as directed, attaching a 
curriculum vitae, a cover letter and the name and contact details of two 
referees.  For informal enquiries please contact Professor Xiaodong Zhang 
xiaodong.zh...@imperial.ac.ukmailto:xiaodong.zh...@imperial.ac.uk


Alternatively, if you are unable to apply online, please contact Kasia Pearce 
k.pea...@imperial.ac.ukmailto:k.pea...@imperial.ac.uk by email to request an 
application form.



Committed to equality and valuing diversity.  We are also an Athena Silver SWAN 
Award winner, a Stonewall Diversity Champion and a Stonewall Top 100 Employer 
2011.

Prof Xiaodong Zhang
Division of Molecular Bioscience
Imperial College London
London, SW7 2AZ
Tel: +44 (0) 207 594 3151
www.imperial.ac.uk/people/xiaodong.zhang

[ccp4bb] Postdoc position - Imperial College London

[Zhang, Xiaodong]

Research Associate at Imperial College London

We are seeking to recruit a Research Associate to work with Professor Xiaodong 
Zhang’s research team in the Division of Molecular Biosciences, Centre for 
Structural Biology, at the South Kensington Campus of Imperial College London 
(www.imperial.ac.uk/people/xiaodong.zhanghttp://www.imperial.ac.uk/people/xiaodong.zhang).

In collaboration with Dr. Stephen West, Cancer Research UK, we are currently 
carrying out structural studies of BRCA2 and interacting partners.  The 
successful candidate will work closely with Dr. Stephen West’s laboratory at 
Cancer Research UK, where the majority of the protein production and 
biochemistry will be carried out.  This position is funded for 3 years by the 
Medical Research Council and it is available from 1 March 2012.

Mutations in two breast cancer susceptibility genes, BRCA1 and BRCA2, have been 
linked to increased risk of developing cancers, especially breast and ovarian 
cancers. BRCA2 is one of the largest proteins in cells and only recently it has 
been successfully purified.  The successful candidate will be responsible for 
carrying out structural studies of BRCA2 and associated complexes, primarily 
using electron microscopy techniques.

Applicants must hold a PhD or equivalent qualifications in a structural biology 
or biochemistry discipline. You must also have research experience in a 
structural biological laboratory environment covering electron microscopy 
single particle analysis or X-ray crystallography and knowledge to at least 
undergraduate level in protein biochemistry and structural biology. It is 
essential for the post holder to have the capacity for innovative high quality 
structural biological research. Knowledge of DNA damage repair is desirable.

The post holder must have excellent written and verbal communication skills, be 
able to conduct detailed reviews of literature, develop and apply new concepts 
well as rapidly learn new research methods. You must be able to demonstrate 
high levels of organisation and problem solving skills, the ability to pay 
close attention to detail, and to show initiative and innovation.  It is also 
essential that you are able to organise your own work with minimal supervision 
ensuring you meet deadlines and research objectives.  You must have experience 
in using advanced computer packages, especially electron microscopy image 
processing packages.

You must have discipline and regard for confidentiality and security at all 
times and be willing to work as member of a team and be open-minded and 
cooperative. A willingness to travel both within the United Kingdom and abroad 
to conduct research and attend conferences/workshops and other meetings is also 
essential.

Closing Date 9 January 2012 (midnight GMT)

How To Apply

Our preferred method of application is online via our website 
http://www3.imperial.ac.uk/employment (please select “Job Search” then enter 
the vacancy reference number including spaces NS 2011 233 KT  into “Keywords”). 
 Please complete and upload an application form as directed, attaching a 
curriculum vitae, a cover letter and the name and contact details of two 
referees.  For informal enquiries please contact Professor Xiaodong Zhang 
xiaodong.zh...@imperial.ac.ukmailto:xiaodong.zh...@imperial.ac.uk


Alternatively, if you are unable to apply online, please contact Kasia Pearce 
k.pea...@imperial.ac.ukmailto:k.pea...@imperial.ac.uk by email to request an 
application form.
Committed to equality and valuing diversity.  We are also an Athena Silver SWAN 
Award winner, a Stonewall Diversity Champion and a Stonewall Top 100 Employer 
2011.

Professor Xiaodong Zhang
Imperial College London
Division of Molecular Biosciences
504, Wolfson laboratories
South Kensington, London, SW7 2AZ
(0) 207 594 3151
xiaodong.zh...@imperial.ac.ukmailto:xiaodong.zh...@imperial.ac.uk
http://www.imperial.ac.uk/people/xiaodong.zhang