Re: [ccp4bb] A Max Perutz question

[Zachary A. Wood]

Thank you to everyone who responded.
I have a request in at both Nature (thanks Jonathan Davies and Daniel Bonsor 
for the article link) and also to the LMB (thanks to Harry Powell for helping 
me find the right person to talk to). A special thank you to my dear friend 
Savvas Savvides, who pointed me to Georgina Ferry’s biography of Max Perutx 
(Max Perutz and the secret of life). After a quick trip to the library, I now 
have a much better photo.

Best regards,

Z


***
Zachary A. Wood, Ph.D.
Associate Professor and Graduate Coordinator
Department of Biochemistry & Molecular Biology
University of Georgia
Life Sciences Building, Rm A426B
120 Green Street
Athens, GA  30602-7229
Office: 706-583-0304
Lab:706-583-0303
FAX: 706-542-1738
***

On Apr 10, 2019, at 11:38 AM, Savvas Savvides 
mailto:savvas.savvi...@ugent.be>> wrote:

Hey Zac
A good scan of page 228 in Georgina Ferry’s biography of Max Perutx (Max Perutz 
and the secret of life) will do the trick. It is a 18x13 cm photo. I have it in 
front of me!

best
Savvas

On 10 Apr 2019, at 16:29, Zachary A. Wood mailto:z...@uga.edu>> 
wrote:

Hello Fellow Structural Enthusiasts,

My apologies for the slightly off-topic question. I am trying to track down a 
higher resolution image of the jpg that I have attached. I use this photo of 
Max Perutz when I am teaching about protein folding, and have always wanted a 
better quality one. I believe it is credited to Nature, and I am trying to find 
out what issue, but I am hoping that one of you may have more information or 
perhaps even a better photo. Thanks for any help, and for those of you who may 
never have seen this photo before, I hope you enjoy it. I like to imagine that 
Perutz is considering the challenges associated with folding that chain after 
he determined the crystal structure. If you have never read the discussion in 
his famous Nature paper, I will leave you with a relevant quote of him 
referring to the structural similarity between horse hemoglobin and sperm whale 
myoglobin, in which he predicts the thermodynamic hypothesis (Anfinsen’s dogma):

“How does this arise? It is scarcely conceivable that a three-dimensional 
template forces the chain to take up this fold. More probably, the chain, once 
synthesized and provided with a haem group around which it can coil, takes up 
this configuration spontaneously, as the only one which satisfies the 
stereochemical requirements of its amino acid sequence.”

Thank you for any help you may be able to offer!

 Best regards,

Z

***
Zachary A. Wood, Ph.D.
Associate Professor and Graduate Coordinator
Department of Biochemistry & Molecular Biology
University of Georgia
Life Sciences Building, Rm A426B
120 Green Street
Athens, GA  30602-7229
Office: 706-583-0304
Lab:706-583-0303
FAX: 706-542-1738
***




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Re: [ccp4bb] A Max Perutz question

[Mitchell D. Miller]

You can also do a reverse image search with tineye
https://www.tineye.com/search/153d902d2e4567ccb3299daefa3cef8d207d197a/

or google image search
https://www.google.com/search?tbs=sbi:AMhZZiua3avdA9z9KnzBOe4pBpsmp-1LJjdEXd13gP1bdXWtunUl2CB6caY5wjn56t8GA8l9KNMqKZdLYHBYPpAuwanPvVp6nJImULD5vgQ9FtisQkTSb5t6Cme58vhCq8Ui2VhStHnEXzHkr4EOgy_1y35oGW4pkLBRc4gQdYYazjC8AR3gqBGoBcwWrxAg7Jnytas9YRdy12rrY4OGg9UnShQgqJSNjDJVnjdsIrzevtFAF0hVY0yKBKahxLAY8lxwjWrYu_1hPB7aY8Il_11RYWHT32QuTvvd3kM943QUxMlQox0zmyMsB0NCuzyJzNkOrhm9lfDf_1k9HpikGcP-m_1wIUF5AWmbznw=1878=1260=search=X=0ahUKEwi4_Z-56cXhAhUSQq0KHUHGCtcQ9Q8IJCgA

to find more versions of the image.
Regards,
Mitch

Quoting Jonathan Davies :


See below:

https://www.nature.com/articles/449144a

--
Jonathan Davies, PhD
Postdoctoral Researcher, Stenmark Lab
Department of Biochemistry and Biophysics
Stockholm University
Sweden







On 10 Apr 2019, at 16:29, Zachary A. Wood  
mailto:z...@uga.edu>> wrote:


Hello Fellow Structural Enthusiasts,

My apologies for the slightly off-topic question. I am trying to  
track down a higher resolution image of the jpg that I have  
attached. I use this photo of Max Perutz when I am teaching about  
protein folding, and have always wanted a better quality one. I  
believe it is credited to Nature, and I am trying to find out what  
issue, but I am hoping that one of you may have more information or  
perhaps even a better photo. Thanks for any help, and for those of  
you who may never have seen this photo before, I hope you enjoy it.  
I like to imagine that Perutz is considering the challenges  
associated with folding that chain after he determined the crystal  
structure. If you have never read the discussion in his famous  
Nature paper, I will leave you with a relevant quote of him  
referring to the structural similarity between horse hemoglobin and  
sperm whale myoglobin, in which he predicts the thermodynamic  
hypothesis (Anfinsen’s dogma):


“How does this arise? It is scarcely conceivable that a  
three-dimensional template forces the chain to take up this fold.  
More probably, the chain, once synthesized and provided with a haem  
group around which it can coil, takes up this configuration  
spontaneously, as the only one which satisfies the stereochemical  
requirements of its amino acid sequence.”


Thank you for any help you may be able to offer!

Best regards,

Z

***
Zachary A. Wood, Ph.D.
Associate Professor and Graduate Coordinator
Department of Biochemistry & Molecular Biology
University of Georgia
Life Sciences Building, Rm A426B
120 Green Street
Athens, GA  30602-7229
Office: 706-583-0304
Lab:706-583-0303
FAX: 706-542-1738
***




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Re: [ccp4bb] A Max Perutz question

[Savvas Savvides]

Hey Zac
A good scan of page 228 in Georgina Ferry’s biography of Max Perutx (Max Perutz 
and the secret of life) will do the trick. It is a 18x13 cm photo. I have it in 
front of me!

best 
Savvas

> On 10 Apr 2019, at 16:29, Zachary A. Wood  wrote:
> 
> Hello Fellow Structural Enthusiasts,
> 
> My apologies for the slightly off-topic question. I am trying to track down a 
> higher resolution image of the jpg that I have attached. I use this photo of 
> Max Perutz when I am teaching about protein folding, and have always wanted a 
> better quality one. I believe it is credited to Nature, and I am trying to 
> find out what issue, but I am hoping that one of you may have more 
> information or perhaps even a better photo. Thanks for any help, and for 
> those of you who may never have seen this photo before, I hope you enjoy it. 
> I like to imagine that Perutz is considering the challenges associated with 
> folding that chain after he determined the crystal structure. If you have 
> never read the discussion in his famous Nature paper, I will leave you with a 
> relevant quote of him referring to the structural similarity between horse 
> hemoglobin and sperm whale myoglobin, in which he predicts the thermodynamic 
> hypothesis (Anfinsen’s dogma):
> 
> “How does this arise? It is scarcely conceivable that a three-dimensional 
> template forces the chain to take up this fold. More probably, the chain, 
> once synthesized and provided with a haem group around which it can coil, 
> takes up this configuration spontaneously, as the only one which satisfies 
> the stereochemical requirements of its amino acid sequence.” 
> 
> Thank you for any help you may be able to offer!
> 
>  Best regards,
> 
> Z
> 
> ***
> Zachary A. Wood, Ph.D.
> Associate Professor and Graduate Coordinator  
> Department of Biochemistry & Molecular Biology
> University of Georgia
> Life Sciences Building, Rm A426B
> 120 Green Street
> Athens, GA  30602-7229
> Office: 706-583-0304
> Lab:706-583-0303
> FAX: 706-542-1738
> ***
> 
> 
> To unsubscribe from the CCP4BB list, click the following link:
> https://www.jiscmail.ac.uk/cgi-bin/webadmin?SUBED1=CCP4BB=1 
> 



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Re: [ccp4bb] A Max Perutz question

[Jonathan Davies]

See below:

https://www.nature.com/articles/449144a

--
Jonathan Davies, PhD
Postdoctoral Researcher, Stenmark Lab
Department of Biochemistry and Biophysics
Stockholm University
Sweden







On 10 Apr 2019, at 16:29, Zachary A. Wood mailto:z...@uga.edu>> 
wrote:

Hello Fellow Structural Enthusiasts,

My apologies for the slightly off-topic question. I am trying to track down a 
higher resolution image of the jpg that I have attached. I use this photo of 
Max Perutz when I am teaching about protein folding, and have always wanted a 
better quality one. I believe it is credited to Nature, and I am trying to find 
out what issue, but I am hoping that one of you may have more information or 
perhaps even a better photo. Thanks for any help, and for those of you who may 
never have seen this photo before, I hope you enjoy it. I like to imagine that 
Perutz is considering the challenges associated with folding that chain after 
he determined the crystal structure. If you have never read the discussion in 
his famous Nature paper, I will leave you with a relevant quote of him 
referring to the structural similarity between horse hemoglobin and sperm whale 
myoglobin, in which he predicts the thermodynamic hypothesis (Anfinsen’s dogma):

“How does this arise? It is scarcely conceivable that a three-dimensional 
template forces the chain to take up this fold. More probably, the chain, once 
synthesized and provided with a haem group around which it can coil, takes up 
this configuration spontaneously, as the only one which satisfies the 
stereochemical requirements of its amino acid sequence.”

Thank you for any help you may be able to offer!

 Best regards,

Z

***
Zachary A. Wood, Ph.D.
Associate Professor and Graduate Coordinator
Department of Biochemistry & Molecular Biology
University of Georgia
Life Sciences Building, Rm A426B
120 Green Street
Athens, GA  30602-7229
Office: 706-583-0304
Lab:706-583-0303
FAX: 706-542-1738
***




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Re: [ccp4bb] A Max Perutz question

[Bonsor, Daniel]

https://www.nature.com/articles/449144a

Daniel A Bonsor PhD.
Sundberg Lab
Institute of Human Virology
University of Maryland, Baltimore
725 W Lombard Street N370
Baltimore
Maryland
MD 21201
Tel: (410) 706-7457


From: CCP4 bulletin board [mailto:CCP4BB@JISCMAIL.AC.UK] On Behalf Of Zachary 
A. Wood
Sent: Wednesday, April 10, 2019 10:30 AM
To: CCP4BB@JISCMAIL.AC.UK
Subject: [ccp4bb] A Max Perutz question

Hello Fellow Structural Enthusiasts,

My apologies for the slightly off-topic question. I am trying to track down a 
higher resolution image of the jpg that I have attached. I use this photo of 
Max Perutz when I am teaching about protein folding, and have always wanted a 
better quality one. I believe it is credited to Nature, and I am trying to find 
out what issue, but I am hoping that one of you may have more information or 
perhaps even a better photo. Thanks for any help, and for those of you who may 
never have seen this photo before, I hope you enjoy it. I like to imagine that 
Perutz is considering the challenges associated with folding that chain after 
he determined the crystal structure. If you have never read the discussion in 
his famous Nature paper, I will leave you with a relevant quote of him 
referring to the structural similarity between horse hemoglobin and sperm whale 
myoglobin, in which he predicts the thermodynamic hypothesis (Anfinsen’s dogma):

“How does this arise? It is scarcely conceivable that a three-dimensional 
template forces the chain to take up this fold. More probably, the chain, once 
synthesized and provided with a haem group around which it can coil, takes up 
this configuration spontaneously, as the only one which satisfies the 
stereochemical requirements of its amino acid sequence.”

Thank you for any help you may be able to offer!

 Best regards,

Z

***
Zachary A. Wood, Ph.D.
Associate Professor and Graduate Coordinator
Department of Biochemistry & Molecular Biology
University of Georgia
Life Sciences Building, Rm A426B
120 Green Street
Athens, GA  30602-7229
Office: 706-583-0304
Lab:706-583-0303
FAX: 706-542-1738
***
[cid:image001.jpg@01D4EF89.4B618FB0]



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[ccp4bb] A Max Perutz question

[Zachary A. Wood]

Hello Fellow Structural Enthusiasts,

My apologies for the slightly off-topic question. I am trying to track down a 
higher resolution image of the jpg that I have attached. I use this photo of 
Max Perutz when I am teaching about protein folding, and have always wanted a 
better quality one. I believe it is credited to Nature, and I am trying to find 
out what issue, but I am hoping that one of you may have more information or 
perhaps even a better photo. Thanks for any help, and for those of you who may 
never have seen this photo before, I hope you enjoy it. I like to imagine that 
Perutz is considering the challenges associated with folding that chain after 
he determined the crystal structure. If you have never read the discussion in 
his famous Nature paper, I will leave you with a relevant quote of him 
referring to the structural similarity between horse hemoglobin and sperm whale 
myoglobin, in which he predicts the thermodynamic hypothesis (Anfinsen’s dogma):

“How does this arise? It is scarcely conceivable that a three-dimensional 
template forces the chain to take up this fold. More probably, the chain, once 
synthesized and provided with a haem group around which it can coil, takes up 
this configuration spontaneously, as the only one which satisfies the 
stereochemical requirements of its amino acid sequence.”

Thank you for any help you may be able to offer!

 Best regards,

Z

***
Zachary A. Wood, Ph.D.
Associate Professor and Graduate Coordinator
Department of Biochemistry & Molecular Biology
University of Georgia
Life Sciences Building, Rm A426B
120 Green Street
Athens, GA  30602-7229
Office: 706-583-0304
Lab:706-583-0303
FAX: 706-542-1738
***
[cid:442ED6C1-8442-400E-9156-C7C062ABC0EC]



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