[ccp4bb] Job Advert: Drug Discovery Project Research Scientist position, Francis Crick Institute, London, UK.

[David Briggs]

Dear all,

We have a position available at the Francis Crick Institute - please share with 
any soon-to-finish PhD students and postdocs who might be interested:

We seek a talented, highly motivated and independent post-doctoral project 
research scientist to work on a project to design protein kinase C beta 
selective inhibitors for B cell malignancies. Work will be carried out in Neil 
McDonald's laboratory at the Francis Crick Institute, in collaboration with 
clinician-scientist Ingo Ringshausen at the University of Cambridge, and is 
funded by a Cancer Research Horizon Therapeutic Catalyst Award.

The project will be funded for 18 months in the first instance, with the 
potential for extension depending on progress.

The project will build upon prior work within our laboratory to characterise 
and develop new, selective kinase inhibitors. The work will involve both 
optimisation of existing inhibitors, and the parallel discovery of novel 
inhibitors using an XChem Fragment screening approach at Diamond Light Source.

The Francis Crick Institute is situated in central London, and is the largest 
single-site biomedical research institute in Europe, with excellent provision 
for X-ray crystallography and medicinal chemistry to allow rapid 
characterisation and follow-up of any lead compounds.

Prior experience with baculovirus protein expression and X-ray crystallography 
would be advantageous.

Informal enquiries can be made to Professor Neil McDonald 
(neil.mcdon...@crick.ac.uk).
Application Deadline: 1st Sept 2023.

For more details about the role and the application process, please see:

https://crick.wd3.myworkdayjobs.com/External/job/London/Postdoctoral-Project-Research-Scientist---Signalling-and-Structural-Laboratory_R1245-1



--

Dr David C. Briggs CSci MRSB (he/him)

Principal Laboratory Research Scientist

Signalling and Structural Biology Lab

The Francis Crick Institute

London, UK

Working hours: Mon-Fri 0900-1700

==

about.me/david_briggs | 
OrcID | Google Scholar 


The Francis Crick Institute Limited is a registered charity in England and 
Wales no. 1140062 and a company registered in England and Wales no. 06885462, 
with its registered office at 1 Midland Road London NW1 1AT



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[ccp4bb] Job advert: Postdoc position CryoEM

[Panne, Daniel (Prof.)]

Dear all,

We have another open position in our Institute!

The Panne group focuses on signal processing on enhancers and how 3D genome 
organisation contributes to various aspects of genome function. For examples of 
recent work see Nature 578, 472–476 (2020); NSMB 27, 233–239 (2020); Nature 
562, 538–544 (2018).

We are located at the the Leicester Institute of Structural and Chemical 
Biology (LISCB), a cross-disciplinary entity that brings together 
internationally renowned research in structural biology, single molecule 
approaches and chemical biology at the University of Leicester. The Institute 
provides access to world-class research facilities, including X-ray 
crystallography, biological NMR spectroscopy, single molecule microscopy and 
the state-of-the-art Midlands Regional Cryo-EM facility.

About you
Successful candidate should have a background in structural studies by single 
particle cryoEM. They must have a track record in conducting internationally 
competitive research. We are looking for a creative and ambitious person with 
good communication skills and keen to work on challenging projects.

LISCB is a flagship research institute recently established by the University 
of Leicester, UK. Our state-of-the-art cryoEM facility houses a TFS Titan Krios 
G3 equipped with a Bioquantum-K3, screening microscope and ancillary equipment. 
For further information and to apply please see the link below:

Research Associate (Structural Biology of Genome 
Regulation)

Closing date is 11 December 2022.

Please get in touch if there are questions concerning this role!

All the best,

--
Daniel Panne
Professor of Structural Biology
Department of Molecular and Cell Biology
University of Leicester
Lancaster Road, Leicester, LE1 7RH, UK
T: +44 (0) 116 229 7408
daniel.pa...@le.ac.uk



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[ccp4bb] Job advert: Postdoc CryoEM

[Panne, Daniel (Prof.)]

Dear all,

We currently have an open postdoc position in our Institute!

The Panne group focuses on signal processing on enhancers and how 3D genome 
organisation contributes to various aspects of genome function. For examples of 
recent work see Nature 578, 472–476 (2020); NSMB 27, 233–239 (2020); Nature 
562, 538–544 (2018).

We are located at the the Leicester Institute of Structural and Chemical 
Biology (LISCB) is a cross-disciplinary entity that brings together 
internationally renowned research in structural biology, single molecule 
approaches and chemical biology at the University of Leicester. The Institute 
provides access to world-class research facilities, including X-ray 
crystallography, biological NMR spectroscopy, single molecule microscopy and 
the state-of-the-art Midlands Regional Cryo-EM facility.

About you
Successful candidate should have a background in structural studies by single 
particle cryoEM. They must have a track record in conducting internationally 
competitive research. We are looking for a creative and ambitious person with 
good communication skills and keen to work on challenging projects.

LISCB is one of five flagship research institutes recently established by the 
University of Leicester, UK. We have excellent access to state-of-the-art 
structural biology technologies including a Krios cryo-EM microscope equipped 
with K3/BioQuantum and in house GPU cluster for data processing.

For further information and to apply please see the link below:

Research Associate (Structural Biology of Genome 
Regulation)

Closing date is August 31st 2022.

All the best,

--
Daniel Panne
Professor of Structural Biology
Department of Molecular and Cell Biology
University of Leicester
Lancaster Road, Leicester, LE1 7RH, UK
T: +44 (0) 116 229 7408
daniel.pa...@le.ac.uk




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[ccp4bb] Job advert for a structural biology/biophysics role in PROTAC drug discovery (with active link)

[David Zollman (Staff)]

Dear all,

Sorry for posting twice, but my previous post contained a dead link.


Dear all,



We have a particularly exciting job opportunity in our lab, the PROTAC drug 
discovery collaboration between the group of Prof Alessio Ciulli at the 
University of Dundee and Boehringer Ingelheim. Our group are world leaders in 
the field of PROTACs, which has rapidly become one of the hottest topics in 
drug discovery. We are looking to recruit one new team member to help expand 
our structural biology, protein production and biophysical efforts.

If you have relevant doctoral/post-doctoral experience and are interested in 
joining a highly motivated, dynamic, interdisciplinary group at the interface 
of academia and industry, the deadline for application is Thursday 18th 
February. The post is available for an immediate start, with funding until 31st 
August 2023 in the first instance. Salary will depend on experience, but the 
appointment will be at Grade 7 on the University's salary scale (between 
£32,817 - £40,322). The full job advert including details on how to apply can 
be found at:

https://www.lifesci.dundee.ac.uk/vacancies/2021/jan/18/structural-biology-biophysics-scientist-protac-drug-discovery
Best wishes,
David Zollman
Structural Biology & Biophysics Scientist (PROTAC drug discovery) | School of 
Life Sciences - 
lifesci.dundee.ac.uk
The School of Life Sciences at the University of Dundee is a world-class 
academic institution with a reputation for the excellence of its research, its 
high quality teaching and student experience, and the strong impact of its 
activities outside academia. With 900 staff from over 60 countries worldwide 
the School provides a dynamic, multi-national, collegiate and diverse 
environment with state ...
www.lifesci.dundee.ac.uk


The University of Dundee is a registered Scottish Charity, No: SC015096



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[ccp4bb] Job advert for a structural biology/biophysics role in PROTAC drug discovery

[David Zollman (Staff)]

Dear all,



We have a particularly exciting job opportunity in our lab, the PROTAC drug 
discovery collaboration between the group of Prof Alessio Ciulli at the 
University of Dundee and Boehringer Ingelheim. Our group are world leaders in 
the field of PROTACs, which has rapidly become one of the hottest topics in 
drug discovery. We are looking to recruit one new team member to help expand 
our structural biology, protein production and biophysical efforts.

If you have relevant doctoral/post-doctoral experience and are interested in 
joining a highly motivated, dynamic, interdisciplinary group at the interface 
of academia and industry, the deadline for application is Thursday 18th 
February. The post is available for an immediate start, with funding until 31st 
August 2023 in the first instance. Salary will depend on experience, but the 
appointment will be at Grade 7 on the University's salary scale (between 
£32,817 - £40,322). The full job advert including details on how to apply can 
be found at 
https://ig5.i-grasp.com/fe/tpl_uod01.asp?newms=jj=104360=14197



Best wishes,

David Zollman


The University of Dundee is a registered Scottish Charity, No: SC015096



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[ccp4bb] Job advert - Principal Investigator - Integral Membrane Proteins, University of Oxford

[Alex Bullock]

I hope this will PI job posting might interest some of you...

A Principal Investigator post is available at the University of Oxford to lead 
an existing medium-sized research group participating in the EU IMI2 EUbOpen 
and ReSOLUTE consortia. The group is focused on the structure determination of 
human integral membrane proteins, particularly Solute Carrier (SLC) proteins, 
by X-ray crystallography and/or cryo-EM, as well as the development of binders, 
including small molecule chemical inhibitors/agonists and 
antibodies/nanobodies. Applicants should have relevant technical expertise and 
experience of managing staff. The successful candidate will benefit from a 
large portfolio of expression constructs, structural projects and assays 
already developed by the team. The post is funded to 30 April 2025 in the first 
instance.

Host institution:
https://www.cmd.ox.ac.uk/team

Advert link:
https://my.corehr.com/pls/uoxrecruit/erq_jobspec_version_4.display_form?p_company=10_internal_external=E_display_in_irish=N_process_type=_applicant_no=_form_profile_detail=_display_apply_ind=Y_refresh_search=Y_recruitment_id=148147

Kind regards

Alex




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[ccp4bb] Job advert for a structural biology/biophysics role in PROTAC drug discovery

[David Zollman (Staff)]

Dear all,



We have a particularly exciting job opportunity in our lab, the PROTAC drug 
discovery collaboration between the group of Prof Alessio Ciulli at the 
University of Dundee and Boehringer Ingelheim. Our group are world leaders in 
the field of PROTACs, which has rapidly become one of the hottest topics in 
drug discovery. We are looking to recruit one new team member to help expand 
our structural biology, protein production and biophysical efforts.

If you have relevant doctoral/post-doctoral experience and are interested in 
joining a highly motivated, dynamic, interdisciplinary group at the interface 
of academia and industry, the deadline for application is Sunday 30th August. 
The post is available to start on 1st September 2020 and is for 3 years. Salary 
will depend on experience, but the appointment will be at Grade 7 on the 
University's salary scale (between £32,817 - £40,322). The full job advert 
including details on how to apply can be found at 
https://ig5.i-grasp.com/fe/tpl_uod01.asp?newms=jj=104360=14197



Best wishes,

David Zollman

The University of Dundee is a registered Scottish Charity, No: SC015096



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[ccp4bb] Job Advert, University of Leeds

[Goldman, Adrian]

Hi,

I have a 3-year postdoctoral position in my laboratory at Leeds for a 
structural biologist (broadly defined) to continue our work on integral 
membrane pyrophosphatases (Kellosalo et al., Science, 337 p473 (2012); Li et 
al., Nature Comm, 7, 13596 (2016); Vidilaseris et al., Sci Adv 5, eaav7574 
(2019)).

The closing date is January 18th, and further information can be found here:

To view the advert use the link below:

http://jobs.leeds.ac.uk/FBSBM1137

I have a modest sized  (about 12 people) , collaborative, enthusiastic lab 
located in the Astbury centre in Leeds.

Adrian Goldman





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[ccp4bb] Job Advert

[Phillips, Chris]

Please see the recent job advert for a position with AstraZeneca in  Cambridge.

http://jobs.astrazeneca.com/jobs/details/l1rRD1248-senior-scientist-crystallography



Chris Phillips
Associate Director, Protein Structure, UK
_

AstraZeneca
RD | Innovative Medicines | Discovery Sciences
50S38, Mereside, Alderley Park, Macclesfield, Cheshire, UK, SK10 4TG
T: +44 (0)1625 513316
chris.phill...@astrazeneca.commailto:rick.dav...@astrazeneca.com

 P Please consider the environment before printing this e-mail



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[ccp4bb] Job advert: Research Fellow at the University of Leicester, Structural Studies of Protein-Drug Interactions

[Bayliss, Richard (Dr.)]

A position is available in the Centre for Translational Therapeutics (CTT) 
within the College of Medicine, Biological Sciences and Psychology for a 
talented postdoctoral structural biologist to work on a collaborative in-house 
structural biology projects, with an emphasis on structure-based drug discovery 
and development. The CTT is headed by Prof. Andrew Tobin and aims to facilitate 
early phase drug discovery within the College. The scientist will be based in 
the Department of Biochemistry and will work alongside the groups of Prof. Mark 
Carr (NMR spectroscopy) and Dr Richard Bayliss (X-ray crystallography), who 
have strong track records in structure-based drug discovery. The scientist will 
determine the structures of proteins that are targeted by CTT and characterise 
their interactions with candidate compounds. The proposed work will involve 
close interactions with other postdoctoral scientists within the CTT, research 
groups across the College and medicinal chemistry collaborators. The CTT and 
Department of Biochemistry are superbly equipped for inhibitor discovery using 
mobility-shift, label-free and thermal shift assays, as well as for all aspects 
of NMR spectroscopy and X-ray crystallography based structural biology, with 
excellent supporting facilities for recombinant protein expression and 
purification.

The successful postdoctoral research fellow will have a proven track record in 
structural biology, with significant experience in X-ray crystallography and/or 
NMR-based approaches. A willingness to apply either approach to solve protein 
structures would be desirable. A strong interest in knowledge-based drug 
discovery is essential. The ability and willingness to travel to meetings with 
collaborators and to use off-campus research facilities is essential. Good 
communication and presentation skills are also a pre-requisite.

Salary Grade 8 - £39,257 to £44,166 per annum. Available immediately for an 
initial period of 1 year, with the expectation of extension for a further 2 
years

Informal enquiries may be made to Dr Richard Bayliss, Tel +44 (0)116 229 7100, 
E.mail richard.bayl...@le.ac.uk; or Prof. Mark Carr, Tel: +44 (0)116 229 7075, 
E.mail: md...@le.ac.uk; or Prof. Andrew Tobin, Tel: +44 (0)116 252 2935, Email: 
t...@le.ac.uk

Applications must be made through the University jobs page, on which further 
details are available 
(http://www2.le.ac.uk/offices/jobs/opportunities/jobsearch - reference MBP00666)

The closing date for this post is midnight on 19th August 2012. 

=
Dr Richard Bayliss, Reader in Structural Biology
Department of Biochemistry
Henry Wellcome Building
University of Leicester
Lancaster Road, Leicester
LE1 9HN

Tel: 0116 2297100
Web: 
http://www2.le.ac.uk/departments/biochemistry/staff/richard-bayliss/research

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[ccp4bb] job advert

[Frank Kozielski]

thank you for posting the message below to the ccp4bb
Frank


The Beatson Institute for Cancer Research

Postdoctoral Scientist – Protein Crystallography

Salary from £25,500 – £38,000 (Depending on experience)

3 year fixed term contract

The Beatson Institute in Glasgow is one of Europe's leading cancer research 
centres. It is core funded by Cancer Research UK and supports cutting edge 
research into the molecular mechanisms of cancer development. The Institute has 
recently moved to a new facility that provides an outstanding research 
environment, underpinned by state-of-the art core services and advanced 
technologies. 

We are seeking an experienced protein crystallographer to investigate the 
structure of cancer-related proteins, to work in a recently established 
research group interested in the kinesin superfamily with a focus on human 
mitotic kinesins and their associated proteins. Many of these proteins are good 
targets for drug development in cancer chemotherapy. In addition, we 
collaborate with other groups at the Institute to determine the structures of 
cancer-related proteins.

We have a well-equipped laboratory for all aspects of structural work including 
ÄKTA protein purification systems, a Mosquito nano-drop robot, an automated 
storage and visualisation system (Formulatrix), and a Rigaku HighFlux Homelab 
microfocus diffraction system. In addition, we are well equipped to 
characterise the biochemistry of protein - inhibitor complexes towards the 
optimisation of lead compounds in collaboration with our chemistry colleagues.  
 For more details please refer to our web site at 
http://www.beatson.gla.ac.uk/Regulation-of-Cancer-Cell-Proliferation-and-Growth/Frank-Kozielski-Molecular-Motors.html

The successful applicant must hold a PhD in protein crystallography and have 
successfully completed at least one post-doctoral position in the same field. A 
good theoretical background in protein crystallography and extensive experience 
in the determination of protein structures will be strongly favoured.

Applications with CV and names of two referees should be sent to Prof. Frank 
Kozielski, The Beatson Institute for Cancer Research, Garscube Estate, 
Switchback Road, Bearsden, Glasgow, G61 1BD, Scotland (FAX: +44 141 942 3653) 
or by Email to [EMAIL PROTECTED]

[ccp4bb] Job advert: Postdoctoral and PhD student posts at the University of Leuven, Belgium

[Sergei Strelkov]

1. A postdoctoral position is available to work with Prof. Sergei 
Strelkov in
the Laboratory for Biocrystallography, Department of Pharmaceutical 
Sciences,
Catholic University of Leuven. The successful candidate should have 
considerable
experience in protein crystallography, especially including cloning, 
purification and crystallization
of recombinant proteins, as well as a strong publication record. Good 
communicational
skills and ability to guide junior group members are essential. The post 
is fully funded by the
University of Leuven 'OT' grant for a period of up to four years, 
pending sufficient progress.


The main research project will be aimed at elucidating the 
three-dimensional structure
of intermediate filaments using X-ray crystallography, small-angle X-ray 
scattering
and other biophysical methods. For background information see Strelkov 
et al

(2002) EMBO J 21, 1255-1266; Strelkov et al (2003) Bioessays 25, 243-251;
Herrmann et al (2007) Nature Reviews Molecular Cell Biology, 8, 562-573.
In addition, the postdoctoral fellow will participate in further 
collaborative,

high-impact medically-oriented projects focussed on protein structure.
Our laboratory is hosted in a brand-new building and is fully equipped with
an X-ray diffractometer (Rigaku/Mar), crystallization facilities, wet 
labs and a computer cluster.


2. In addition, a PhD student ('assistent') post in protein 
crystallography is available.
The applicants should have a BSc or MSc diploma in biophysics, 
bioinformatics or a related field
and at least some experience in research. The post is funded for a 
period of up to five years.
NB: the PhD student will participate in the teaching of undergraduate 
students; correspondingly,

proficiency in Dutch is required!

The search for suitable candidates is open immediately and will continue 
until the positions are
filled. The target starting date for either post is October 1st, 2007, 
but can be negotiated.
Please send your application, together with a detailed CV, publication 
list and a list of referees,
to: sergei.strelkov(at)pharm.kuleuven.be. Leuven is a university town 
located 20 km
east of Brussels. Rich history, remarkable architecture and proximity of 
both Brussels

and the North sea make Leuven an outstanding location.

Laboratory homepage is at http://pharm.kuleuven.be/anafar
(currently undergoing a major overhaul, to be competed in a few weeks' 
time).


--
Prof. Sergei V. Strelkov
Laboratory for Biocrystallography
Department of Pharmaceutical Sciences, Catholic University of Leuven
Campus Gasthuisberg, ON2 Herestraat 49 bus 822, 3000 Leuven, Belgium
Work phone: +32 16 33 08 45  Fax: +32 16 32 34 69
Mobile: +32 486 29 41 32


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