Re: [ccp4bb] Substrate/Ligand Induced Oligomerization of enzymes
If you are willing to include cofactor-induced oligomerization instead of substrate-induced, how about imidazoleglycerol-phosphate dehydratase (IGPD) ? Inactive trimer: 1RHY http://www.ncbi.nlm.nih.gov/pubmed/14724278 Active 24-mer in presence of Mn2+ ions: 2F1D http://www.ncbi.nlm.nih.gov/pubmed/16338409 best wishes Pete On 9 Aug 2013, at 01:03, Shiva Bhowmik gene1...@gmail.com wrote: Dear All, I am looking for references and/or example of substrate or ligand induced oligomerization of enzymes related to activation. Any help in this regard would be greatly appreciated. Thanks. Shiva Prof Peter Artymiuk Krebs Institute Department of Molecular Biology Biotechnology University of Sheffield Sheffield S10 2TN ENGLAND
Re: [ccp4bb] Substrate/Ligand Induced Oligomerization of enzymes
Dear All, Thank you for your responses. Below is the compiled list of examples of substrate/ligand/co-factor induced oligomerization: http://www.pnas.org/content/97/13/7096.full.pdf http://www.ncbi.nlm.nih.gov/pubmed/15710608 http://www.ncbi.nlm.nih.gov/pubmed/17725819 http://www.ncbi.nlm.nih.gov/pubmed/14724278 http://www.ncbi.nlm.nih.gov/pubmed/16338409 http://pubs.acs.org/doi/abs/10.1021/bi301067w http://pubs.acs.org/doi/abs/10.1021/bi2005637 http://pubs.acs.org/doi/abs/10.1021/bi201381e http://pubs.acs.org/doi/full/10.1021/bi301593c Have a great weekend. Cheers, Shiva On Thu, Aug 8, 2013 at 5:03 PM, Shiva Bhowmik gene1...@gmail.com wrote: Dear All, I am looking for references and/or example of substrate or ligand induced oligomerization of enzymes related to activation. Any help in this regard would be greatly appreciated. Thanks. Shiva
Re: [ccp4bb] Substrate/Ligand Induced Oligomerization of enzymes
Hi Shiva, There are some other enzyme systems activated by ligand induced oligomerization in addition to the ones on this list: 1) DNA polymerase dimerization on DNA binding 2) Restriction enzyme dimerization on DNA binding (an example is the type IIs FokI) 3) membrane enzyme receptors like receptor tyrosine kinase, etc. 4) metallopeptidases with dimerization domain Thanks, Debanu. -Original Message- From: CCP4 bulletin board [mailto:CCP4BB@JISCMAIL.AC.UK] On Behalf Of Shiva Bhowmik Sent: Friday, August 09, 2013 10:19 AM To: CCP4BB@JISCMAIL.AC.UK Subject: Re: [ccp4bb] Substrate/Ligand Induced Oligomerization of enzymes Dear All, Thank you for your responses. Below is the compiled list of examples of substrate/ligand/co-factor induced oligomerization: http://www.pnas.org/content/97/13/7096.full.pdf http://www.ncbi.nlm.nih.gov/pubmed/15710608 http://www.ncbi.nlm.nih.gov/pubmed/17725819 http://www.ncbi.nlm.nih.gov/pubmed/14724278 http://www.ncbi.nlm.nih.gov/pubmed/16338409 http://pubs.acs.org/doi/abs/10.1021/bi301067w http://pubs.acs.org/doi/abs/10.1021/bi2005637 http://pubs.acs.org/doi/abs/10.1021/bi201381e http://pubs.acs.org/doi/full/10.1021/bi301593c Have a great weekend. Cheers, Shiva On Thu, Aug 8, 2013 at 5:03 PM, Shiva Bhowmik gene1...@gmail.com wrote: Dear All, I am looking for references and/or example of substrate or ligand induced oligomerization of enzymes related to activation. Any help in this regard would be greatly appreciated. Thanks. Shiva
[ccp4bb] Substrate/Ligand Induced Oligomerization of enzymes
Dear All, I am looking for references and/or example of substrate or ligand induced oligomerization of enzymes related to activation. Any help in this regard would be greatly appreciated. Thanks. Shiva
Re: [ccp4bb] Substrate/Ligand Induced Oligomerization of enzymes
FKBP ? http://www.pnas.org/content/97/13/7096.full.pdf Jürgen On Aug 8, 2013, at 8:03 PM, Shiva Bhowmik wrote: Dear All, I am looking for references and/or example of substrate or ligand induced oligomerization of enzymes related to activation. Any help in this regard would be greatly appreciated. Thanks. Shiva .. Jürgen Bosch Johns Hopkins University Bloomberg School of Public Health Department of Biochemistry Molecular Biology Johns Hopkins Malaria Research Institute 615 North Wolfe Street, W8708 Baltimore, MD 21205 Office: +1-410-614-4742 Lab: +1-410-614-4894 Fax: +1-410-955-2926 http://lupo.jhsph.edu
Re: [ccp4bb] Substrate/Ligand Induced Oligomerization of enzymes
Jaffe's morpheeins might be of interest to you. Here is one paper: http://www.ncbi.nlm.nih.gov/pubmed/15710608 Sent from Jack's iPad On Aug 8, 2013, at 7:21 PM, Shiva Bhowmik gene1...@gmail.com wrote: Dear All, I am looking for references and/or example of substrate or ligand induced oligomerization of enzymes related to activation. Any help in this regard would be greatly appreciated. Thanks. Shiva
