Re: [ccp4bb] real dimer vs crystal packing
Thanks, Artem! PDE2A also uses three domains to form a homodimmer. However, without the catalytic domain, the GAF B domain swings out. This is an excellent example for the restrictions set by the multidomain context. Anyone knows other examples? Thanks a lot! PDE2 full length versus domain only structures, I think. Artem On Thu, Jan 12, 2012 at 10:03 AM, Qiang Chen c...@red.dfci.harvard.eduwrote: Hi, I'm working on a multi-domain protein which uses three domains to form homodimer, and the full-length structure is available. We have solved the structure of one binding domain alone and found its homo-binding mode is totally different from that of the full-length protein. Do you know examples or papers discussing the similar subjects (crystal packing shows false binding mode)? Thanks a lot! Qiang The information in this e-mail is intended only for the person to whom it is addressed. If you believe this e-mail was sent to you in error and the e-mail contains patient information, please contact the Partners Compliance HelpLine at http://www.partners.org/complianceline . If the e-mail was sent to you in error but does not contain patient information, please contact the sender and properly dispose of the e-mail.
[ccp4bb] real dimer vs crystal packing
Hi, I'm working on a multi-domain protein which uses three domains to form homodimer, and the full-length structure is available. We have solved the structure of one binding domain alone and found its homo-binding mode is totally different from that of the full-length protein. Do you know examples or papers discussing the similar subjects (crystal packing shows false binding mode)? Thanks a lot! Qiang The information in this e-mail is intended only for the person to whom it is addressed. If you believe this e-mail was sent to you in error and the e-mail contains patient information, please contact the Partners Compliance HelpLine at http://www.partners.org/complianceline . If the e-mail was sent to you in error but does not contain patient information, please contact the sender and properly dispose of the e-mail.
Re: [ccp4bb] real dimer vs crystal packing
PDE2 full length versus domain only structures, I think. Artem On Thu, Jan 12, 2012 at 10:03 AM, Qiang Chen c...@red.dfci.harvard.eduwrote: Hi, I'm working on a multi-domain protein which uses three domains to form homodimer, and the full-length structure is available. We have solved the structure of one binding domain alone and found its homo-binding mode is totally different from that of the full-length protein. Do you know examples or papers discussing the similar subjects (crystal packing shows false binding mode)? Thanks a lot! Qiang The information in this e-mail is intended only for the person to whom it is addressed. If you believe this e-mail was sent to you in error and the e-mail contains patient information, please contact the Partners Compliance HelpLine at http://www.partners.org/complianceline . If the e-mail was sent to you in error but does not contain patient information, please contact the sender and properly dispose of the e-mail.
