Re: [Felvtalk] Anemia and Aranesp
There is no problem with the recommended change. Amani From: Felvtalk [mailto:felvtalk-boun...@felineleukemia.org] On Behalf Of Maribel Piloto Sent: May-13-18 1:44 AM To: felvtalk@felineleukemia.org Subject: Re: [Felvtalk] Anemia and Aranesp Hi Amani and everyone else who’s been helping me with this post - I shared the recommended drug protocol with a friend of mine who isn’t a vet but has worked for years in animal rescue and has also worked at both the local Humane Society and the local county shelter. She also attends a lot of vet conferences. She sent me the following... If your vet is willing to prescribe this regimen, I'd give it a try with one CRITICAL CHANGE. NEVER use doxycycline tablets/capsules with cats as doxy can cause esophageal strictures. You can get compounded doxycycline is 50 mg/ml, so dose would be 0.4 - 0.5 ml twice a day. Do you foresee any issues with using the Doxy in liquid format? I also wanted to get the Prednisolone in liquid as Flaqui is very difficult to pill. Thanks Maribel "The greatness of a nation can be judged by the way its animals are treated." -Mohandas Ghandi On May 10, 2018, at 11:02 PM, Amani Oakley <aoak...@oakleylegal.com<mailto:aoak...@oakleylegal.com>> wrote: Thank you Sandy. You saved me from repeating what I have posted so very often now. Mirabel, regarding the Aranesp, it is a product which mimics the effects of erythropoietin. I do not believe it will assist because erythropoietin tells the bone marrow to produce more red cells. With FeLV, it infects the cells in the bone marrow which produce all three cell lines (red cells, white cells, platelets). The cells are taken over and destroyed by the virus, which means that the bone marrow can no longer produce red cells, white cells and/or platelets. The erythropoietin or Aranesp is speaking to these cells and telling them to churn out more red cells, but the bone marrow cells can no longer do that. My experience with the Winstrol is that after my cat had the very worst results (HAEMATOCRIT OF FIVE!!!, ZERO % RETICULOCYTES, etc.) and AFTER I had given him several bouts of blood transfusions, the Winstrol turned back on the bone marrow and he began producing red cells, white cells and platelets again. Amani From: Felvtalk [mailto:felvtalk-boun...@felineleukemia.org] On Behalf Of Sandy Sent: May-10-18 8:48 PM To: Maribel Piloto; felvtalk@felineleukemia.org<mailto:felvtalk@felineleukemia.org> Subject: Re: [Felvtalk] Anemia and Aranesp This is long because I just copied this whole conversation - but your answer lies in this combination of drugs - make no mistake this will work if your vet will give it a try - there is nothing to lose - BUT you and the vet need to act immediately. - good luck. You will probably get more responses - Sandy W Winstrol – 1 mg twice a day Doxycycline – 1/5 to ¼ tablet (100 mg) twice a day Prednisolone – ½ 5 mg tablet, twice a day If there are problems with the intestines (vomiting, constipation, slow moving stools, stools of large diameters, all of which might be indicative of the effect of the virus on the intestines) you can try adding ¼ tablet of apometocloprimide. If the haematocrit level is REALLY REALLY low – like below 5-8, you might consider starting the Winstrol at 2 mg twice a day for a week, to try and kickstart things quickly, but given that there is going to be a likely increase in liver enzymes with the use of Winstrol, recognize that this might also increase the liver enzymes faster. Hope this helps! Amani From: Felvtalk [mailto:felvtalk-boun...@felineleukemia.org] On Behalf Of gary Sent: January-27-17 4:04 PM To: felvtalk@felineleukemia.org<mailto:felvtalk@felineleukemia.org> Subject: Re: [Felvtalk] My baby recently diagnosed with FeLV Amani, Could you please give the dosages used for Zander's Protocol? I know they must have been previously given, but I cannot seem to find them. Thanks, Gary On 9/16/2016 8:52 AM, Amani Oakley wrote: Hi Sherri I hope you got some good news today. However, as you know, my experience is that the Winstrol needs to be used long term before the red cells are back into the normal range. I continue to recommend use of the Doxycyline to interfere with viral RNA synthesis. The Winstrol does not attack the virus, though I believe it makes the cat stronger overall and able to fight back. But at the outset of the treatment regime, I believe you must have the Doxycycline on board to try and reduce the viral load, or at least, keep it from rising. Amani ___ Felvtalk mailing list Felvtalk@felineleukemia.org<mailto:Felvtalk@felineleukemia.org> http://felineleukemia.org/mailman/listinfo/felvtalk_felineleukemia.org Hi Liz The only thing that works to turn back on red cell production is Winstrol (Stanazolol). It is an ANABOLIC steroid (as opposed to most steroids we are used to getting, li
Re: [Felvtalk] Anemia and Aranesp
Hi Amani and everyone else who’s been helping me with this post - I shared the recommended drug protocol with a friend of mine who isn’t a vet but has worked for years in animal rescue and has also worked at both the local Humane Society and the local county shelter. She also attends a lot of vet conferences. She sent me the following... > If your vet is willing to prescribe this regimen, I'd give it a try with one > CRITICAL CHANGE. NEVER use doxycycline tablets/capsules with cats as doxy > can cause esophageal strictures. You can get compounded doxycycline is 50 > mg/ml, so dose would be 0.4 - 0.5 ml twice a day. Do you foresee any issues with using the Doxy in liquid format? I also wanted to get the Prednisolone in liquid as Flaqui is very difficult to pill. Thanks Maribel "The greatness of a nation can be judged by the way its animals are treated." -Mohandas Ghandi > On May 10, 2018, at 11:02 PM, Amani Oakley <aoak...@oakleylegal.com> wrote: > > Thank you Sandy. You saved me from repeating what I have posted so very often > now. > > Mirabel, regarding the Aranesp, it is a product which mimics the effects of > erythropoietin. I do not believe it will assist because erythropoietin tells > the bone marrow to produce more red cells. With FeLV, it infects the cells in > the bone marrow which produce all three cell lines (red cells, white cells, > platelets). The cells are taken over and destroyed by the virus, which means > that the bone marrow can no longer produce red cells, white cells and/or > platelets. The erythropoietin or Aranesp is speaking to these cells and > telling them to churn out more red cells, but the bone marrow cells can no > longer do that. My experience with the Winstrol is that after my cat had the > very worst results (HAEMATOCRIT OF FIVE!!!, ZERO % RETICULOCYTES, etc.) and > AFTER I had given him several bouts of blood transfusions, the Winstrol > turned back on the bone marrow and he began producing red cells, white cells > and platelets again. > > Amani > > From: Felvtalk [mailto:felvtalk-boun...@felineleukemia.org] On Behalf Of Sandy > Sent: May-10-18 8:48 PM > To: Maribel Piloto; felvtalk@felineleukemia.org > Subject: Re: [Felvtalk] Anemia and Aranesp > > This is long because I just copied this whole conversation - but your answer > lies in this combination of drugs - make no mistake this will work if your > vet will give it a try - there is nothing to lose - BUT you and the vet need > to act immediately. - good luck. You will probably get more responses - Sandy > W > > > > Winstrol – 1 mg twice a day > > Doxycycline – 1/5 to ¼ tablet (100 mg) twice a day > > Prednisolone – ½ 5 mg tablet, twice a day > > If there are problems with the intestines (vomiting, constipation, slow > moving stools, stools of large diameters, all of which might be indicative of > the effect of the virus on the intestines) you can try adding ¼ tablet of > apometocloprimide. > > If the haematocrit level is REALLY REALLY low – like below 5-8, you might > consider starting the Winstrol at 2 mg twice a day for a week, to try and > kickstart things quickly, but given that there is going to be a likely > increase in liver enzymes with the use of Winstrol, recognize that this might > also increase the liver enzymes faster. > > Hope this helps! Amani > > > > From: Felvtalk [mailto:felvtalk-boun...@felineleukemia.org] On Behalf Of gary > Sent: January-27-17 4:04 PM > To: felvtalk@felineleukemia.org > Subject: Re: [Felvtalk] My baby recently diagnosed with FeLV > > Amani, > > Could you please give the dosages used for Zander's Protocol? I know they > must have been previously given, but I cannot seem to find them. > > Thanks, Gary > > On 9/16/2016 8:52 AM, Amani Oakley wrote: > > Hi Sherri > > I hope you got some good news today. However, as you know, my experience is > that the Winstrol needs to be used long term before the red cells are back > into the normal range. I continue to recommend use of the Doxycyline to > interfere with viral RNA synthesis. The Winstrol does not attack the virus, > though I believe it makes the cat stronger overall and able to fight back. > But at the outset of the treatment regime, I believe you must have the > Doxycycline on board to try and reduce the viral load, or at least, keep it > from rising. > > Amani > > ___ > Felvtalk mailing list > Felvtalk@felineleukemia.org > http://felineleukemia.org/mailman/listinfo/felvtalk_felineleukemia.org > > Hi Liz > > The only thing that works to turn back on red cell production is Winstrol > (Stanazolol). It is an
Re: [Felvtalk] Anemia and Aranesp
Maribel, When I gave it to Tigger, the results were very fast – within days – so much so that the lab re-ran his results, thinking they must have made a mistake the first time around and that he was not as flat-lined as they had originally thought. Amani is the expert in the lab results though and she can tell you the best time to do the follow up blood work. Ardy From: Felvtalk [mailto:felvtalk-boun...@felineleukemia.org] On Behalf Of Maribel Piloto Sent: Saturday, May 12, 2018 4:41 PM To: felvtalk@felineleukemia.org Subject: Re: [Felvtalk] Anemia and Aranesp Thank you everyone. Vet was impressed with all your e-mails and agreed to get me the Winstrol and other two meds. We’re trying to get it from a local pharmacy but if not, Roadrunner apparently has it. One question - how soon after I start this drug regimen should I have bloodwork done on Flaqui to see if it’s working? Maribel "The greatness of a nation can be judged by the way its animals are treated." -Mohandas Ghandi On May 12, 2018, at 5:32 PM, Ardy Robertson <ar...@centurytel.net <mailto:ar...@centurytel.net> > wrote: Hi Maribel, I totally agree about Zander’s Protocol being your best option, and that it needs to be started as soon as possible. One thing I might add, if it was not mentioned in the comments by Amani and Sandy is that if your vet will order it for you, they might not know of a source for it. Your vet can prescribe and order it online at www.diamondbackdrugs.com <http://www.diamondbackdrugs.com> -- this is a large compounding pharmacy in Arizona, and they will ship it anywhere. Their phone number is 866-578-4420 if you want to call them. The Winstrol comes in several flavors, and forms. I believe it was around $40 when I used it for my Tigger. Best wishes to you and Flaqui. Ardy From: Felvtalk [mailto:felvtalk-boun...@felineleukemia.org] On Behalf Of Maribel Piloto Sent: Thursday, May 10, 2018 10:38 PM To: felvtalk@felineleukemia.org <mailto:felvtalk@felineleukemia.org> Subject: Re: [Felvtalk] Anemia and Aranesp Thank you guys.Very encouraging. Now let’s see if I can get my vet to prescribe the Winstrol. I’m sending him all the things you have written. Maribel "The greatness of a nation can be judged by the way its animals are treated." -Mohandas Ghandi On May 10, 2018, at 11:02 PM, Amani Oakley <aoak...@oakleylegal.com <mailto:aoak...@oakleylegal.com> > wrote: Thank you Sandy. You saved me from repeating what I have posted so very often now. Mirabel, regarding the Aranesp, it is a product which mimics the effects of erythropoietin. I do not believe it will assist because erythropoietin tells the bone marrow to produce more red cells. With FeLV, it infects the cells in the bone marrow which produce all three cell lines (red cells, white cells, platelets). The cells are taken over and destroyed by the virus, which means that the bone marrow can no longer produce red cells, white cells and/or platelets. The erythropoietin or Aranesp is speaking to these cells and telling them to churn out more red cells, but the bone marrow cells can no longer do that. My experience with the Winstrol is that after my cat had the very worst results (HAEMATOCRIT OF FIVE!!!, ZERO % RETICULOCYTES, etc.) and AFTER I had given him several bouts of blood transfusions, the Winstrol turned back on the bone marrow and he began producing red cells, white cells and platelets again. Amani From: Felvtalk [mailto:felvtalk-boun...@felineleukemia.org] On Behalf Of Sandy Sent: May-10-18 8:48 PM To: Maribel Piloto; felvtalk@felineleukemia.org <mailto:felvtalk@felineleukemia.org> Subject: Re: [Felvtalk] Anemia and Aranesp This is long because I just copied this whole conversation - but your answer lies in this combination of drugs - make no mistake this will work if your vet will give it a try - there is nothing to lose - BUT you and the vet need to act immediately. - good luck. You will probably get more responses - Sandy W Winstrol – 1 mg twice a day Doxycycline – 1/5 to ¼ tablet (100 mg) twice a day Prednisolone – ½ 5 mg tablet, twice a day If there are problems with the intestines (vomiting, constipation, slow moving stools, stools of large diameters, all of which might be indicative of the effect of the virus on the intestines) you can try adding ¼ tablet of apometocloprimide. If the haematocrit level is REALLY REALLY low – like below 5-8, you might consider starting the Winstrol at 2 mg twice a day for a week, to try and kickstart things quickly, but given that there is going to be a likely increase in liver enzymes with the use of Winstrol, recognize that this might also increase the liver enzymes faster. Hope this helps! Amani From: Felvtalk [mailto:felvtalk-boun...@felineleukemia.org] On Behalf Of gary Sent: January-27-17 4:04 PM To: felvtalk@felineleukemia.org <mai
Re: [Felvtalk] Anemia and Aranesp
Thank you everyone. Vet was impressed with all your e-mails and agreed to get me the Winstrol and other two meds. We’re trying to get it from a local pharmacy but if not, Roadrunner apparently has it. One question - how soon after I start this drug regimen should I have bloodwork done on Flaqui to see if it’s working? Maribel "The greatness of a nation can be judged by the way its animals are treated." -Mohandas Ghandi > On May 12, 2018, at 5:32 PM, Ardy Robertson <ar...@centurytel.net> wrote: > > Hi Maribel, > I totally agree about Zander’s Protocol being your best option, and that it > needs to be started as soon as possible. One thing I might add, if it was not > mentioned in the comments by Amani and Sandy is that if your vet will order > it for you, they might not know of a source for it. Your vet can prescribe > and order it online at www.diamondbackdrugs.com -- this is a large > compounding pharmacy in Arizona, and they will ship it anywhere. Their phone > number is 866-578-4420 if you want to call them. The Winstrol comes in > several flavors, and forms. I believe it was around $40 when I used it for my > Tigger. Best wishes to you and Flaqui. > Ardy > > > From: Felvtalk [mailto:felvtalk-boun...@felineleukemia.org] On Behalf Of > Maribel Piloto > Sent: Thursday, May 10, 2018 10:38 PM > To: felvtalk@felineleukemia.org > Subject: Re: [Felvtalk] Anemia and Aranesp > > Thank you guys.Very encouraging. Now let’s see if I can get my vet to > prescribe the Winstrol. I’m sending him all the things you have written. > > Maribel > > "The greatness of a nation can be judged by the way its animals are treated." > -Mohandas Ghandi > > On May 10, 2018, at 11:02 PM, Amani Oakley <aoak...@oakleylegal.com> wrote: > > Thank you Sandy. You saved me from repeating what I have posted so very often > now. > > Mirabel, regarding the Aranesp, it is a product which mimics the effects of > erythropoietin. I do not believe it will assist because erythropoietin tells > the bone marrow to produce more red cells. With FeLV, it infects the cells in > the bone marrow which produce all three cell lines (red cells, white cells, > platelets). The cells are taken over and destroyed by the virus, which means > that the bone marrow can no longer produce red cells, white cells and/or > platelets. The erythropoietin or Aranesp is speaking to these cells and > telling them to churn out more red cells, but the bone marrow cells can no > longer do that. My experience with the Winstrol is that after my cat had the > very worst results (HAEMATOCRIT OF FIVE!!!, ZERO % RETICULOCYTES, etc.) and > AFTER I had given him several bouts of blood transfusions, the Winstrol > turned back on the bone marrow and he began producing red cells, white cells > and platelets again. > > Amani > > From: Felvtalk [mailto:felvtalk-boun...@felineleukemia.org] On Behalf Of Sandy > Sent: May-10-18 8:48 PM > To: Maribel Piloto; felvtalk@felineleukemia.org > Subject: Re: [Felvtalk] Anemia and Aranesp > > This is long because I just copied this whole conversation - but your answer > lies in this combination of drugs - make no mistake this will work if your > vet will give it a try - there is nothing to lose - BUT you and the vet need > to act immediately. - good luck. You will probably get more responses - Sandy > W > > > > Winstrol – 1 mg twice a day > > Doxycycline – 1/5 to ¼ tablet (100 mg) twice a day > > Prednisolone – ½ 5 mg tablet, twice a day > > If there are problems with the intestines (vomiting, constipation, slow > moving stools, stools of large diameters, all of which might be indicative of > the effect of the virus on the intestines) you can try adding ¼ tablet of > apometocloprimide. > > If the haematocrit level is REALLY REALLY low – like below 5-8, you might > consider starting the Winstrol at 2 mg twice a day for a week, to try and > kickstart things quickly, but given that there is going to be a likely > increase in liver enzymes with the use of Winstrol, recognize that this might > also increase the liver enzymes faster. > > Hope this helps! Amani > > > > From: Felvtalk [mailto:felvtalk-boun...@felineleukemia.org] On Behalf Of gary > Sent: January-27-17 4:04 PM > To: felvtalk@felineleukemia.org > Subject: Re: [Felvtalk] My baby recently diagnosed with FeLV > > Amani, > > Could you please give the dosages used for Zander's Protocol? I know they > must have been previously given, but I cannot seem to find them. > > Thanks, Gary > > On 9/16/2016 8:52 AM, Amani Oakley wrote: > > Hi Sherri > > I hope you got some good news today
Re: [Felvtalk] Anemia and Aranesp
Hi Maribel, I totally agree about Zander’s Protocol being your best option, and that it needs to be started as soon as possible. One thing I might add, if it was not mentioned in the comments by Amani and Sandy is that if your vet will order it for you, they might not know of a source for it. Your vet can prescribe and order it online at www.diamondbackdrugs.com <http://www.diamondbackdrugs.com> -- this is a large compounding pharmacy in Arizona, and they will ship it anywhere. Their phone number is 866-578-4420 if you want to call them. The Winstrol comes in several flavors, and forms. I believe it was around $40 when I used it for my Tigger. Best wishes to you and Flaqui. Ardy From: Felvtalk [mailto:felvtalk-boun...@felineleukemia.org] On Behalf Of Maribel Piloto Sent: Thursday, May 10, 2018 10:38 PM To: felvtalk@felineleukemia.org Subject: Re: [Felvtalk] Anemia and Aranesp Thank you guys.Very encouraging. Now let’s see if I can get my vet to prescribe the Winstrol. I’m sending him all the things you have written. Maribel "The greatness of a nation can be judged by the way its animals are treated." -Mohandas Ghandi On May 10, 2018, at 11:02 PM, Amani Oakley <aoak...@oakleylegal.com <mailto:aoak...@oakleylegal.com> > wrote: Thank you Sandy. You saved me from repeating what I have posted so very often now. Mirabel, regarding the Aranesp, it is a product which mimics the effects of erythropoietin. I do not believe it will assist because erythropoietin tells the bone marrow to produce more red cells. With FeLV, it infects the cells in the bone marrow which produce all three cell lines (red cells, white cells, platelets). The cells are taken over and destroyed by the virus, which means that the bone marrow can no longer produce red cells, white cells and/or platelets. The erythropoietin or Aranesp is speaking to these cells and telling them to churn out more red cells, but the bone marrow cells can no longer do that. My experience with the Winstrol is that after my cat had the very worst results (HAEMATOCRIT OF FIVE!!!, ZERO % RETICULOCYTES, etc.) and AFTER I had given him several bouts of blood transfusions, the Winstrol turned back on the bone marrow and he began producing red cells, white cells and platelets again. Amani From: Felvtalk [mailto:felvtalk-boun...@felineleukemia.org] On Behalf Of Sandy Sent: May-10-18 8:48 PM To: Maribel Piloto; felvtalk@felineleukemia.org <mailto:felvtalk@felineleukemia.org> Subject: Re: [Felvtalk] Anemia and Aranesp This is long because I just copied this whole conversation - but your answer lies in this combination of drugs - make no mistake this will work if your vet will give it a try - there is nothing to lose - BUT you and the vet need to act immediately. - good luck. You will probably get more responses - Sandy W Winstrol – 1 mg twice a day Doxycycline – 1/5 to ¼ tablet (100 mg) twice a day Prednisolone – ½ 5 mg tablet, twice a day If there are problems with the intestines (vomiting, constipation, slow moving stools, stools of large diameters, all of which might be indicative of the effect of the virus on the intestines) you can try adding ¼ tablet of apometocloprimide. If the haematocrit level is REALLY REALLY low – like below 5-8, you might consider starting the Winstrol at 2 mg twice a day for a week, to try and kickstart things quickly, but given that there is going to be a likely increase in liver enzymes with the use of Winstrol, recognize that this might also increase the liver enzymes faster. Hope this helps! Amani From: Felvtalk [mailto:felvtalk-boun...@felineleukemia.org] On Behalf Of gary Sent: January-27-17 4:04 PM To: felvtalk@felineleukemia.org <mailto:felvtalk@felineleukemia.org> Subject: Re: [Felvtalk] My baby recently diagnosed with FeLV Amani, Could you please give the dosages used for Zander's Protocol? I know they must have been previously given, but I cannot seem to find them. Thanks, Gary On 9/16/2016 8:52 AM, Amani Oakley wrote: Hi Sherri I hope you got some good news today. However, as you know, my experience is that the Winstrol needs to be used long term before the red cells are back into the normal range. I continue to recommend use of the Doxycyline to interfere with viral RNA synthesis. The Winstrol does not attack the virus, though I believe it makes the cat stronger overall and able to fight back. But at the outset of the treatment regime, I believe you must have the Doxycycline on board to try and reduce the viral load, or at least, keep it from rising. Amani ___ Felvtalk mailing list Felvtalk@felineleukemia.org <mailto:Felvtalk@felineleukemia.org> http://felineleukemia.org/mailman/listinfo/felvtalk_felineleukemia.org Hi Liz The only thing that works to turn back on red cell production is Winstrol (Stanazolol). It is an AN
Re: [Felvtalk] Anemia and Aranesp
Thank you guys.Very encouraging. Now let’s see if I can get my vet to prescribe the Winstrol. I’m sending him all the things you have written. Maribel "The greatness of a nation can be judged by the way its animals are treated." -Mohandas Ghandi > On May 10, 2018, at 11:02 PM, Amani Oakley <aoak...@oakleylegal.com> wrote: > > Thank you Sandy. You saved me from repeating what I have posted so very often > now. > > Mirabel, regarding the Aranesp, it is a product which mimics the effects of > erythropoietin. I do not believe it will assist because erythropoietin tells > the bone marrow to produce more red cells. With FeLV, it infects the cells in > the bone marrow which produce all three cell lines (red cells, white cells, > platelets). The cells are taken over and destroyed by the virus, which means > that the bone marrow can no longer produce red cells, white cells and/or > platelets. The erythropoietin or Aranesp is speaking to these cells and > telling them to churn out more red cells, but the bone marrow cells can no > longer do that. My experience with the Winstrol is that after my cat had the > very worst results (HAEMATOCRIT OF FIVE!!!, ZERO % RETICULOCYTES, etc.) and > AFTER I had given him several bouts of blood transfusions, the Winstrol > turned back on the bone marrow and he began producing red cells, white cells > and platelets again. > > Amani > > From: Felvtalk [mailto:felvtalk-boun...@felineleukemia.org] On Behalf Of Sandy > Sent: May-10-18 8:48 PM > To: Maribel Piloto; felvtalk@felineleukemia.org > Subject: Re: [Felvtalk] Anemia and Aranesp > > This is long because I just copied this whole conversation - but your answer > lies in this combination of drugs - make no mistake this will work if your > vet will give it a try - there is nothing to lose - BUT you and the vet need > to act immediately. - good luck. You will probably get more responses - Sandy > W > > > > Winstrol – 1 mg twice a day > > Doxycycline – 1/5 to ¼ tablet (100 mg) twice a day > > Prednisolone – ½ 5 mg tablet, twice a day > > If there are problems with the intestines (vomiting, constipation, slow > moving stools, stools of large diameters, all of which might be indicative of > the effect of the virus on the intestines) you can try adding ¼ tablet of > apometocloprimide. > > If the haematocrit level is REALLY REALLY low – like below 5-8, you might > consider starting the Winstrol at 2 mg twice a day for a week, to try and > kickstart things quickly, but given that there is going to be a likely > increase in liver enzymes with the use of Winstrol, recognize that this might > also increase the liver enzymes faster. > > Hope this helps! Amani > > > > From: Felvtalk [mailto:felvtalk-boun...@felineleukemia.org] On Behalf Of gary > Sent: January-27-17 4:04 PM > To: felvtalk@felineleukemia.org > Subject: Re: [Felvtalk] My baby recently diagnosed with FeLV > > Amani, > > Could you please give the dosages used for Zander's Protocol? I know they > must have been previously given, but I cannot seem to find them. > > Thanks, Gary > > On 9/16/2016 8:52 AM, Amani Oakley wrote: > > Hi Sherri > > I hope you got some good news today. However, as you know, my experience is > that the Winstrol needs to be used long term before the red cells are back > into the normal range. I continue to recommend use of the Doxycyline to > interfere with viral RNA synthesis. The Winstrol does not attack the virus, > though I believe it makes the cat stronger overall and able to fight back. > But at the outset of the treatment regime, I believe you must have the > Doxycycline on board to try and reduce the viral load, or at least, keep it > from rising. > > Amani > > ___ > Felvtalk mailing list > Felvtalk@felineleukemia.org > http://felineleukemia.org/mailman/listinfo/felvtalk_felineleukemia.org > > Hi Liz > > The only thing that works to turn back on red cell production is Winstrol > (Stanazolol). It is an ANABOLIC steroid (as opposed to most steroids we are > used to getting, like prednisone, which is a corticosteroid. > > Anabolic steroids are ones which build muscle, tissue, etc. > > Adding Winstrol to the combination of medication you have your cat on right > now, would be the best thing to do. The Doxycycline acts to slow down or > inhibit the reproduction of the FeLV virus by interfering the RNA > duplication. The prednisone is helpful in keeping inflammation at bay, but > neither of these helps to increase the red cells. The Winstrol acts directly > and very quickly on the bone marrow and seems to get
Re: [Felvtalk] Anemia and Aranesp
Thank you Sandy. You saved me from repeating what I have posted so very often now. Mirabel, regarding the Aranesp, it is a product which mimics the effects of erythropoietin. I do not believe it will assist because erythropoietin tells the bone marrow to produce more red cells. With FeLV, it infects the cells in the bone marrow which produce all three cell lines (red cells, white cells, platelets). The cells are taken over and destroyed by the virus, which means that the bone marrow can no longer produce red cells, white cells and/or platelets. The erythropoietin or Aranesp is speaking to these cells and telling them to churn out more red cells, but the bone marrow cells can no longer do that. My experience with the Winstrol is that after my cat had the very worst results (HAEMATOCRIT OF FIVE!!!, ZERO % RETICULOCYTES, etc.) and AFTER I had given him several bouts of blood transfusions, the Winstrol turned back on the bone marrow and he began producing red cells, white cells and platelets again. Amani From: Felvtalk [mailto:felvtalk-boun...@felineleukemia.org] On Behalf Of Sandy Sent: May-10-18 8:48 PM To: Maribel Piloto; felvtalk@felineleukemia.org Subject: Re: [Felvtalk] Anemia and Aranesp This is long because I just copied this whole conversation - but your answer lies in this combination of drugs - make no mistake this will work if your vet will give it a try - there is nothing to lose - BUT you and the vet need to act immediately. - good luck. You will probably get more responses - Sandy W Winstrol – 1 mg twice a day Doxycycline – 1/5 to ¼ tablet (100 mg) twice a day Prednisolone – ½ 5 mg tablet, twice a day If there are problems with the intestines (vomiting, constipation, slow moving stools, stools of large diameters, all of which might be indicative of the effect of the virus on the intestines) you can try adding ¼ tablet of apometocloprimide. If the haematocrit level is REALLY REALLY low – like below 5-8, you might consider starting the Winstrol at 2 mg twice a day for a week, to try and kickstart things quickly, but given that there is going to be a likely increase in liver enzymes with the use of Winstrol, recognize that this might also increase the liver enzymes faster. Hope this helps! Amani From: Felvtalk [mailto:felvtalk-boun...@felineleukemia.org] On Behalf Of gary Sent: January-27-17 4:04 PM To: felvtalk@felineleukemia.org<mailto:felvtalk@felineleukemia.org> Subject: Re: [Felvtalk] My baby recently diagnosed with FeLV Amani, Could you please give the dosages used for Zander's Protocol? I know they must have been previously given, but I cannot seem to find them. Thanks, Gary On 9/16/2016 8:52 AM, Amani Oakley wrote: Hi Sherri I hope you got some good news today. However, as you know, my experience is that the Winstrol needs to be used long term before the red cells are back into the normal range. I continue to recommend use of the Doxycyline to interfere with viral RNA synthesis. The Winstrol does not attack the virus, though I believe it makes the cat stronger overall and able to fight back. But at the outset of the treatment regime, I believe you must have the Doxycycline on board to try and reduce the viral load, or at least, keep it from rising. Amani ___ Felvtalk mailing list Felvtalk@felineleukemia.org<mailto:Felvtalk@felineleukemia.org> http://felineleukemia.org/mailman/listinfo/felvtalk_felineleukemia.org Hi Liz The only thing that works to turn back on red cell production is Winstrol (Stanazolol). It is an ANABOLIC steroid (as opposed to most steroids we are used to getting, like prednisone, which is a corticosteroid. Anabolic steroids are ones which build muscle, tissue, etc. Adding Winstrol to the combination of medication you have your cat on right now, would be the best thing to do. The Doxycycline acts to slow down or inhibit the reproduction of the FeLV virus by interfering the RNA duplication. The prednisone is helpful in keeping inflammation at bay, but neither of these helps to increase the red cells. The Winstrol acts directly and very quickly on the bone marrow and seems to get red cells generated again, quite promptly. At least it did for my Zander, and I have been contacted directly by several people from this group, who have reported to me that they also saw almost immediate (within 3 days) evidence of their cats’ gums/ears/pads pinkening up. The problem is that Winstrol is a controversial drug because it is also what professional athletes use to get bigger, stronger and faster. Quite unfortunately (since none of our cats are entering the Olympics) that association with doping scandals has cast a shadow on its use in both animal and people medicine. In human medicine, it is the only drug found to be effective in treating hereditary angioedema and anemia. Here is a blurb I found about it: Winstrol was first invented in 1959
Re: [Felvtalk] Anemia and Aranesp
This is long because I just copied this whole conversation - but your answer lies in this combination of drugs - make no mistake this will work if your vet will give it a try - there is nothing to lose - BUT you and the vet need to act immediately. - good luck. You will probably get more responses - Sandy W Winstrol – 1 mg twice a day Doxycycline – 1/5 to ¼ tablet (100 mg) twice a day Prednisolone – ½ 5 mg tablet, twice a day If there are problems with the intestines (vomiting, constipation, slow moving stools, stools of large diameters, all of which might be indicative of the effect of the virus on the intestines) you can try adding ¼ tablet of apometocloprimide. If the haematocrit level is REALLY REALLY low – like below 5-8, you might consider starting the Winstrol at 2 mg twice a day for a week, to try and kickstart things quickly, but given that there is going to be a likely increase in liver enzymes with the use of Winstrol, recognize that this might also increase the liver enzymes faster. Hope this helps! Amani From: Felvtalk [mailto:felvtalk-boun...@felineleukemia.org] On Behalf Of gary Sent: January-27-17 4:04 PM To: felvtalk@felineleukemia.org Subject: Re: [Felvtalk] My baby recently diagnosed with FeLV Amani, Could you please give the dosages used for Zander's Protocol? I know they must have been previously given, but I cannot seem to find them. Thanks, Gary On 9/16/2016 8:52 AM, Amani Oakley wrote: Hi Sherri I hope you got some good news today. However, as you know, my experience is that the Winstrol needs to be used long term before the red cells are back into the normal range. I continue to recommend use of the Doxycyline to interfere with viral RNA synthesis. The Winstrol does not attack the virus, though I believe it makes the cat stronger overall and able to fight back. But at the outset of the treatment regime, I believe you must have the Doxycycline on board to try and reduce the viral load, or at least, keep it from rising. Amani ___ Felvtalk mailing list Felvtalk@felineleukemia.org http://felineleukemia.org/mailman/listinfo/felvtalk_felineleukemia.org Hi Liz The only thing that works to turn back on red cell production is Winstrol (Stanazolol). It is an ANABOLIC steroid (as opposed to most steroids we are used to getting, like prednisone, which is a corticosteroid. Anabolic steroids are ones which build muscle, tissue, etc. Adding Winstrol to the combination of medication you have your cat on right now, would be the best thing to do. The Doxycycline acts to slow down or inhibit the reproduction of the FeLV virus by interfering the RNA duplication. The prednisone is helpful in keeping inflammation at bay, but neither of these helps to increase the red cells. The Winstrol acts directly and very quickly on the bone marrow and seems to get red cells generated again, quite promptly. At least it did for my Zander, and I have been contacted directly by several people from this group, who have reported to me that they also saw almost immediate (within 3 days) evidence of their cats’ gums/ears/pads pinkening up. The problem is that Winstrol is a controversial drug because it is also what professional athletes use to get bigger, stronger and faster. Quite unfortunately (since none of our cats are entering the Olympics) that association with doping scandals has cast a shadow on its use in both animal and people medicine. In human medicine, it is the only drug found to be effective in treating hereditary angioedema and anemia. Here is a blurb I found about it: Winstrol was first invented in 1959. Soon after that, the UK based Winthrop Laboratories created a prescription medicine from it. Later, in 1961, Winthrop’s patent was bought by the US based Sterling that started manufacturing and selling the drug in the American markets. In the beginning, Winstrol was used for a variety of medical reasons. But later, by the 1970s, the FDA had restricted its use to only promoting growth and treating osteoporosis. In the 1980s, there was a termination of the manufacture of anabolic steroids in the American market. But Winstrol was among those steroids which not only survived, but thrived in the 1980s and 1990s. During this period, its use was reinforced as a cure for anemia – as it had the power to boost red blood cell count, and was used as a treatment for facial swelling or angioedema. When the manufacture of Winstrol was finally discontinued, Ovation Pharmaceuticals bought the rights to manufacture it, in 2003. However, Ovation Pharmaceuticals have ceased their operations now, so the Winstrol products available today in the American markets are only generic and not pharmaceutical grade. Outside the USA, however, several large brands still manufacture and sell Winstrol. Genuine Stanozolol can be distinguished in water suspensions because it separates from the liquid into micrometer
[Felvtalk] Anemia and Aranesp
Hi all, I have a Leuk+ girl who is getting very anemic. Her name is Flaqui. She showed up at one of the colonies I feed a couple of months ago (already spayed) and was so thin I thought she was an elderly cat with not much time left so I took her home to give her some comfort in her final days. When I took her to the vet it turned out that she isn't that old (vet things 4-5) but she's Leuk+. I decided to keep her in my room where I have another Leuk+ guy. I'm building a little catio for them outside one of the bedroom windows so they can enjoy the outside. Flaqui's numbers in January 2018 were... RBC - 4.15 M/ul (5.00-10.00) LOWHCT - 20.2% (30.0-45.0) LOWHGB 6.8 g/dl (9.0-15.1) LOWMCV 48.7 fL (41.0-58.0)MCH - 16.5 pg (12.0-20.0)MCHC - 33.8 g/dL (29.0-37.5)RDW - 20.5% (17.3-22.0)%RETIC - 1.3%RETIC - 53.2 K/uL (3.0-50.0) HIGHWBC - 15.30 K/uL (5.50-19.50)EOS - 1.8 K/uL (0.10-0.79) HIGHPLT - 663 K/uL (175-600)Everything else was normal I started her on Liqui-Tinic which is a supplement containing iron and B-12 among other things. Also giving her Vetri-DMG. She initially had very bad diarrhea but I managed to clear this with Metronidazole. She's also been dewormed and got Revolution. Despite eating and showing an interest in food, she has been losing weight (down to 5 lbs) so last week I had bloodwork done again. Here are the results... RBC - 3.79 M/ul (5.00-10.00) LOWHCT - 14.8% (30.0-45.0) LOWHGB 8.1 g/dl (9.0-15.1) LOWMCV 39.2 fL (41.0-58.0) LOWMCH - 21.4 pg (12.0-20.0) HIGHMCHC - --- g/dL (29.0-37.5)RDW - 21.7% (17.3-22.0)%RETIC - 1.1%RETIC - 40.7 K/uL (3.0-50.0)WBC - 22.73. K/uL (5.50-19.50) HIGHNEU - 18.48 K/uL (2.50-12.50) HIGHPLT 698 K/uL (175-600) HIGHEverything else was normal My vet told me to start her on Clavamox since the white blood cell count was high which is indicative on an infection somewhere. I was really alarmed by the HCT number because I had a cat with chronic renal failure and anemia some years back and I know that once the HCT numbers get below 20% it can be very dangerous. With that cat, Grayson, I used Aranesp very successfully to treat his anemia. He eventually succumbed to the kidney failure but the Aranesp kept his anemia at bay. I've been reading that blood transfusions are one of the things to do with Leuk+ cats once the HCT numbers get low but blood transfusions in my area (South FL) are in the $1000 range and I manage 6 colonies and have other cats at home with medical needs including one that needs a full mouth extraction for stomatitis and I just can't spend that type of money on Flaqui. Do you guys think that Aranesp is something that would work on her? She does not have kidney problems. However, based on the reticulocyte levels, she does seem to have non-regenerative anaemia. I read this document at Tanya's Comprehensive Guide to Feline Chronic Kidney Disease that explains that the reticulocyte level needs to be adjusted based on PCV... In particular, since reticulocytes are commonly expressed in percentage terms, they need to be adjusted to allow for the degree of anaemia, i.e. 1% reticulocytes in a cat with a PCV of 20% is twice as many as 1% reticulocytes in a cat with a PCV of 10%. Let's assume your cat's PCV is 18% and the measured reticulocyte count is 0.75%. You multiply the PCV by the measured count, then divide the result by the normal PCV level (35% for many laboratories). In this instance, you would get an adjusted result of 0.39%, which indicates non-regeneration. In contrast, if your cat's PCV was 13% and the measured reticulocyte count was 0.75%, your adjusted result would be 0.28. This also indicates non-regeneration, but it is more severe (i.e. the lower the corrected value, the lower the regenerative response). Flaqui's adjusted reticulocyte level is 14.8HCT X 1.1 RET = 16.28/35 = .46 which indicates non-regeneration. Any help would be appreciated. Flaqui has been doing better the last couple of days. I think the Clavamox helped - but I really wish I could improve those HCT numbers. Maribel & Flaqui. "The greatness of a nation can be judged by the way its animals are treated." -Mohandas Ghandi___ Felvtalk mailing list Felvtalk@felineleukemia.org http://felineleukemia.org/mailman/listinfo/felvtalk_felineleukemia.org
