Make sure also that you do not have a data item or variable called PHI. It may
interfere with PHI() as a function.
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Senior Director
Pharmacometrics R
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From: owner-nmus...@globomaxnm.com On Behalf Of
Leonid Gibiansky
Sent: Wednesday, August 17, 2022 1:48 PM
To: Roeland Wasmann ; nmusers@globomaxnm.com
Subject: [EXTERNAL] Re: [NMusers] Problems when implementing M3 for BLQs
Hi Roeland,
ERROR_TERM in Y and in DUM should differ: one should include EPS() while
the other should use only SD. F_FLAG should be set to zero outside M3
block. What is DRUG.EQ.1, is it parent? there should be a separate M3
part for metabolite.
It would be easier to debug if you would provide the full code of the
ERROR block
Thank you,
Leonid
On 8/16/2022 6:53 AM, Roeland Wasmann wrote:
> Hi all,
>
> I have a problem while trying to implement the m3 method in my model
> with a parent and metabolite. I could really use some help.
>
> About 50% of the parent data is BLQ while the metabolite only has a
> couple of BLQs. When modeling them separately there is no issue but when
> I have them both in one model, I get the following error:
>
> /Recompiling certain components.
> starting wait
> ending wait
> Exiting lpreddo
> Compiling FSUBS
> FSUBS.f90:1322:6:/
>
> / B56=PHI(DUM)/
>
> / 1/
>
> /Error: Unclassifiable statement at (1)
> Building NONMEM Executable
> gfortran: error: fsubs.o: No such file or directory
> No nonmem execution.
> It seems like Fortran compilation by NONMEM's nmfe script failed. Cannot
> start NONMEM.
> Go to the NM_run1 subdirectory and run psn.mod with NONMEM's nmfe script
> to diagnose the problem./
>
> The NM_run1 folder does not provide any answers… The M3 part of the
> error block looks like this:
>
> Y = IPRED + ERROR_TERM
>
> *DUM = (LLOQ-IPRED) / ERROR_TERM
> CUMD = PHI(DUM)
> IF (ICALL.NE.4.AND.BLQ.GT.0.AND.DRUG.EQ.1) THEN
> F_FLAG = 1
> Y = CUMD
> MDVRES = 1
> ENDIF*
>
> When I put the “DUM” part within the PHI (i.e., “*CUMD =
> PHI(((LLOQ-IPRED) / ERROR_TERM))*” the error changes slightly:
>
> /Compiling FSUBS
> FSUBS.f90:1324:6:/
>
> / B58=PHI(B56)/
>
> When I remove the “*.AND.DRUG.EQ.1*” from IF I get:
>
> /FSUBS.f90:1355:6:/
>
> / B61=PHI(DUM)/
>
> Please let me know what info I should provide to better diagnose this
> problem challenge.
>
> Thanks in advance for helping out!
>
> Cheers Roeland
>
> --
>
> *Roeland Wasmann, PharmD, PhD*
>
> Division of Clinical Pharmacology
>
> Department of Medicine
>
> University of Cape Town
>
> K45 Old Main Building
>
> Groote Schuur Hospital
>
> Observatory, Cape Town
>
> 7925 South Africa
>
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