GETTING THE BODY TO  MANUFACTURE NEUROTRANSMITTERS 
_http://www.doctoryourself.com/nerves.html_ 
(http://www.doctoryourself.com/nerves.html)  
 
**The composition of each meal could have a direct effect on  the 
production of chemical signals in the brain.** (The New York Times, January  9, 
1979) 
 
Rather than give a synthetic drug to block or  mimic the body*s chemical 
nerve messengers (neurotransmitters), it is possible  nutritionally to 
encourage the body to make its own natural ones. 
 
If we are what we eat, then our nerves also depend on what  they are fed. 
Here is tremendous potential for the alleviation of  depression, anxiety, 
neuroses, panic attacks and sleep disorders. 
 
NOREPINEPHRINE 
 
A depletion of the neurotransmitter called norepinephrine may  result in 
poor memory, loss of alertness, and clinical depression. The chain of  
chemical events in the body resulting in this substance is: 
 
L-phenylalanine (from protein foods) ->   L-tyrosine (made in the liver) -> 
 dopa -> dopamine ->   norepinephrine ->  epinephrine 
 
This process looks complex but actually is readily  accomplished, 
particularly if the body has plenty of vitamin C. Since one's  dietary supply 
of the 
first ingredient, L-phenylalanine, is usually adequate, it  is more likely 
to be a shortage of vitamin C that limits production of  norepinephrine. 
Physicians giving large doses of vitamin C have had striking  success in 
reversing depression. It is a remarkably safe and inexpensive  approach to try. 
 
ACETYLCHOLINE 
 
Acetylcholine is the end neurotransmitter of your  parasympathetic nerve 
system. This means that, among other things, it  facilitates good digestion, 
deeper breathing, and slower heart rate. You may  perceive its effect as 
**relaxation.** 
 
Your body will make its own acetylcholine from choline.  Choline is 
available in the diet as phosphatidyl choline, found in lecithin. 
 
Lecithin is found in egg yolks and most soy products. Three  tablespoons 
daily of soya lecithin granules provide about five grams (5,000  milligrams) 
of phosphatidyl choline. Long-term use of this amount is favorably  mentioned 
in The Lancet, February 9, 1980.  Lecithin supplementation has no  known 
harmful effects whatsoever.  In fact, your brain by dry weight is  almost 
one-third lecithin! How far can we go with this idea of simply feeding  the 
brain what it is made up of?   In Geriatrics, July 1979, lecithin  is 
considered 
as a therapy to combat memory loss. Studies at MIT show increases  in both 
choline and acetylcholine in the brains of animals after just one  lecithin 
meal. Supplemental choline has even shown promise in treating  Alzheimer*s 
Disease. (Today's Living, February, 1982) 
 
Your body can make much of its own lecithin. Ample amounts of  B-complex 
vitamins, especially B-6 (pyridoxine) must be present  for this to occur. B-6 
deficiency is very common in Americans, and that  **deficiency** is measured 
against an already ridiculously low US RDA of only  two milligrams. The 
amount of B-6 needed for clinical effectiveness in, say,  rabbits is the human 
dose equivalent of 75 mg daily. That is over 35 times more  than the RDA! 
 
Really enormous doses of B-6 taken alone have  produced temporary 
neurological side effects. It usually takes between 2,000 and  5,000 mg daily 
for 
symptoms of numbness or tingling in the extremities. Some  side effects have 
been reported as low as 500 mg daily, but these are very rare  indeed. 
Therapeutic doses between 100 and 500 milligrams daily are commonly  prescribed 
by 
physicians for PMS relief. A few hundred milligrams of individual  B-6, 
especially if taken in addition to the entire B-complex to ensure balance,  is 
very safe indeed. 
 
SEROTONIN 
 
Plentiful serotonin can mean a good night's sleep, and freedom  from 
anxiety during the day. You cannot tell someone to relax unless they have  the 
chemistry to do it. It is safer to let the body make the molecules than to  use 
pharmaceuticals. 
 
Your brain produces serotonin from the amino acid  L-tryptophan. 
L-tryptophan is one of the parts of protein essential to life.  Chicken, nuts, 
beans, 
and dairy products are everyday sources of this natural  and necessary 
substance. (_http://www.doctoryourself.com/prozac.html_ 
(http://www.doctoryourself.com/prozac.html) ) 
 
You can buy L-tryptophan, but is very expensive. There is  little, if any, 
justification for this continued priceyness for L-tryptophan  supplements, 
for it is put in liquid feedings for the elderly and is in all  infant 
formulas. 
 
The good news is that your body can derive similar benefits  from inex
pensive, readily-available vitamin B-3, niacin. 
 
L-tryptophan is broken down into niacin by a 60 to 1 ratio.  That means you 
need a lot of tryptophan to make a little niacin, and a lot of  tryptophan 
is difficult to come up with nowadays. It also means, however, that  only a 
little niacin (1/60th as much) can go a long way.  Niacin does not  make 
serotonin, but may spare it by way of a parallel biochemical mechanism. The  
amount of niacin needed to help relax you for sleep (50 to a few hundred mg) 
is  substantially less than the dose routinely given by cardiologists to 
lower serum  cholesterol levels (several thousand mg/day). 
 
Body saturation of niacin is indicated by a warmness of the  skin and 
blushing or "flushing" sensation. At this point, most persons will also  
experience a feeling of relaxation and ease. Unlike pharmaceutical  
tranquilizers, 
niacin simply feeds the body what it needs to internally and  naturally 
provide relief. 
 
Niacin (or L-tryptophan) has also been  effective in treating 
obsessive-compulsive neurosis (Let*s Live, September 1979)  and even 
schizophrenia. Drs. 
David Hawkins and Linus Pauling have written a  670-page textbook on the 
subject entitled Orthomolecular Psychiatry (1973). This  is a comprehensive 
work and well worth your investigation. 
 
For more information about niacin therapy for mental illness,  please do a 
search for **Hoffer** using the **search** box on the home page. 
 
REFERENCES: 
 
Cheraskin, E., Ringsdorf, W. M. and  Brecher, A.   Psychodietetics  Bantam 
Books, 1974 
 
Galenberg, A. "Tyrosine for the Treatment of Depression,"  American Journal 
of Psychiatry, 147:622, May, 1980 
 
Growden, A. "Neurotransmitter Precursors in the Diet," in  Nutrition and 
the Brain, Wurtman and Wurtman, Eds., 117-181, Raven Press, 1979 
 
Hawkins, D. and Pauling, L. Orthomolecular Psychiatry:  Treatment of 
Schizophrenia  W. H. Freeman, 1973 
 
Hoffer, A. and Walker, M. Orthomolecular Nutrition, Keats,  1978 
 
Huemer, R P. "Brain Food: Neurotransmitters Make You Think,"  Let's Live, 
December, 1981 
 
Lilliston, L. Megavitamins, Fawcett Publications, 1975 
 
Nutrition News, Vol 2, No. 9, 1979 
 
Passwater, R. Supernutrition, Pocket Books, 1975 
 
Pauling, L.  How To Live Longer and Feel Better, W. H.  Freeman, 1986 
 
"Choline and Lecithin for a Better Memory," Today's Living,  February, 1982
 
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