Those authors raise a fair point though, don't they: if nothing else,
"suppremacy" is an utterly daft word to use in any scientific context,
since it brings nothing technical to the table.
Before geek triumphalism became the rage (or maybe before the need for
grant-gaining hyperbole?), we
Happy New Years to all!
delete the ligand you fitted and any water molecules near the ligand and run a
few rounds of refinement to get an unbiased omit map.
The cavity may be filled with bulk solvent by the refinement program, which can
reduce the difference signal from whatever is there.
Hi Katrin,
First, I think you meant that the green density disappears after contouring at
6 Sigma and not 6 A?
That you ligand is only partly visible due to disorder and has partial
occupancy happens often and is no reason for concern. Of course, you could try
soaking with a 10-fold higher
