Hi Shankar,
If you mean what I think you mean - yes, hundreds - but it depends on
how strict you are about identical'
Lots of proteins have repeat domains in them with the same fold (and
homologous sequence) and therefore very similar (if not quite
identical) tertiary structure.
Some examples
Depending on your definition of 'identical', examples of repeated gene
duplication contribute to these:
You could look at glyoxalases where there are dimeric examples where
each monomer is composed of a repeated subdomain (A1-A2:A1-A2) and
monomeric examples where a further duplication has
thank you all for quick answers.
-shankar
On Thu, Jul 2, 2009 at 12:47 PM, Charlie Bond charles.b...@uwa.edu.auwrote:
Depending on your definition of 'identical', examples of repeated gene
duplication contribute to these:
You could look at glyoxalases where there are dimeric examples where
Savvas
From: CCP4 bulletin board [mailto:ccp...@jiscmail.ac.uk] On Behalf Of
Shankar Prasad Kanaujia
Sent: Thursday, July 02, 2009 7:40 AM
To: CCP4BB@JISCMAIL.AC.UK
Subject: [ccp4bb] multi-domain protein with identical tertiary structure
Dear CCP4 users,
Is there any multi-domain
Hi Shankar,
Another fascinating example might be Dscam (Down Syndrome cell adhesion
molecule) with multiple Ig like domains and Fibronectin type III domains.
Different splice isoforms are expressed in different nerves, and it serves
as a recognition module, same repels, different ones attract.
The cadmium-utilizing marine diatom carbonic anhydrase (CA) protein has
three consecutive CA domains that have very similar structures but
non-identical sequences.
See:
Structure and metal exchange in the cadmium carbonic anhydrase of marine
diatoms.
Xu Y, Feng L, Jeffrey PD, Shi Y, Morel
[mailto:ccp...@jiscmail.ac.uk] On Behalf Of
Shankar Prasad Kanaujia
Sent: Thursday, July 02, 2009 12:40 AM
To: CCP4BB@JISCMAIL.AC.UK
Subject: [ccp4bb] multi-domain protein with identical tertiary structure
Dear CCP4 users,
Is there any multi-domain protein (with at least two domains) which has
identical
The same is true for Porphyridium purpureum
beta-CA and Halothiobacillus neapolitanus beta-CA. Both are composed of
pseudodimers composed of two structurally homologous domains. In the
case of H. neapolitanus, the domains have very little sequence
homology, and one domain has lost its active
Dear CCP4 users,
Is there any multi-domain protein (with at least two domains) which has
identical tertiary structure of each domain ?
Thanking you.
-regards
shankar
