[ccp4bb] 2 PhD positions in Structural Mitochondrial Biology at CPR, University of Copenhagen

[Eva Kummer]

Dear colleagues,

2 PhD positions in structural biology of mitochondria will be available in my 
newly established lab at the Novo Nordisk Center for Protein Research (CPR) at 
University Copenhagen. Our group has a deep interest in understanding the 
biology of human mitochondria with a specific focus on how these important 
organelles maintain their DNA and how they produce functional RNA species. The 
candidates will employ single-particle cryo-EM to understand the structure and 
working principles of mitochondrial machines involved in these processes.

We are looking for highly motivated candidates that are eager to acquire new 
methodology and have a genuine interest in understanding molecular mechanisms. 
At CPR, you will join an interdisciplinary, collaborative and supportive 
environment. The institute provides access to state-of-the-art infrastructure 
and instrumentation including a Titan Krios and a Glacios both equipped with 
Falcon III DED, as well as multiple smaller screening instruments. In addition, 
the center entertains a number of core facilities including protein production, 
crystallography, biophysics, high performance computing, mass spectrometry, and 
genomics. So you will find everything that is needed to help you succeed.
For informal inquiries, please contact me directly: 
eva.kum...@cpr.ku.dk. Applications, however, will 
have to be submitted via the online portal: 
https://employment.ku.dk/phd/?show=153662

For further information about the lab, please refer to:
https://www.cpr.ku.dk/research/protein-structure-function-program/kummer/

Application deadline is 11 April 2021!

I would appreciate if you could forward this advertisement also to interested 
candidates that may not be part of the mailing list. Thank you!

All the best,
Eva




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Re: [ccp4bb] Chiral center R/S labels in Coot

[Paul Emsley]

On 11/03/2021 01:12, Weston Lane wrote:
Does anyone know if there is a way of showing if a chiral compound is 
R or S configuration in Coot?  It would be nice to not resort to 
thumbs while modelling!


Coot does not show you if your chiral compound is R or S. The closest it 
gets is the consistency of chiral centres with the dictionary. Validate 
-> Validation Outliers will show chiral volume outliers (amongst other 
things).



Paul.



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[ccp4bb] Chiral center R/S labels in Coot

[Weston Lane]

Does anyone know if there is a way of showing if a chiral compound is R or
S configuration in Coot?  It would be nice to not resort to thumbs while
modelling!

Thanks!

Wes



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[ccp4bb] Scientist Structural Biology (cryo-electron microscopy and single-particle analysis)

[Veli-Pekka Jaakola]

Hi,

For the expansion of our structural biology team in Brussels/Ghent we are 
currently looking for a Scientist Structural Biology (cryo-electron microscopy 
and single-particle analysis).

Confo Therapeutics, a spin-off of VIB and VUB, is a drug discovery company 
built around a disruptive technology which enables it to address 'undruggable' 
GPCRs. The company is building a portfolio of transformative medicines in 
various disease areas. Confo Therapeutics' headquarter is located on the 
Technology Park in Zwijnaarde/Ghent and the company has a second exploitation 
site on the Etterbeek campus of the Vrije Universiteit Brussel. More 
information about Confo's technology and strategy can be found on 
www.confotherapeutics.com.

Role Overview:
Confo Therapeutics is seeking a motivated structural biologist with strong 
expertise on single particle cryo-EM

Detailed job description:
Process single particle cryo-EM data including handling raw data, 
interpretation, 3D reconstruction and map refinement, and model building in 
various pipe-line projects.
Maintenance and development of the infrastructure for cryo-EM, with emphasis on 
supporting both internal drug-development pipeline programs and technology 
development.
Support high-performance structural biology computing infrastructure including 
management of large data storage and processing clusters.
Provide scientific expertise to cross-functional project teams on progress and 
explore the feasibility of experiment proposals.
Train scientists in cryo-EM data processing using various state-of-the-art 
software for 3D reconstructions, atomic model building and in fundamentals of 
cryo-EM sample handling and preparation.
In a project leader role, you will be expected to maintain focus and provide 
direction to the team members with clear project plans and defined timelines, 
maintain productive relationships with project team members and communicate 
progress against goals in a multidisciplinary setting: chemistry, biology, 
pharmacology, and modeling.

Job requirements
Ph.D. or equivalent in structural biology, biophysics, or a related field with 
postdoctoral/industrial experience in structural biology and 2+ years of 
documented experience in cryo-EM of proteins.
Experience with cryo-EM sample preparation protocols including negative 
staining and sample vitrification.
Experience with Linux OS (Installation, configuration and maintenance).
Strong expertise in single particle cryo-EM image processing and 3D 
reconstruction (expertise user programs such as RELION, CryoSPARC, CryOLO, 
WARP).  Expert on data-processing and structure solution of small size protein 
and transient membrane protein complexes (<150 kDa) is desired.
Experience with software for model building and refinement such as Phenix, 
CCP4-em, Chimera, Rosetta, Coot etc.
Experience with operation of screening and high-resolution data-collection 
microscopes.
A true team player with a track record of successful collaborations.
Skills in managing multiple projects and capability to prioritize.


Our offer:
A competitive compensation package with extensive benefits.
The chance to continuously grow as a professional.
A job where you can make a difference.
An entrepreneurial and stimulating working environment in a growing and 
ambitious biotech company.

Please visit 
https://confotherapeutics.recruitee.com/o/scientist-structural-biology to apply 
for this position

BR,

Veli

--
Veli-Pekka Jaakola
Head of Structural Biology
Confo Therapeutics
Technologiepark 94
9052 Zwijnaarde
Belgium
+32 471 80 01 56
www.confotherapeutics.com
veli-pekka.jaak...@confotherapeutics.com
https://www.linkedin.com/in/vpjaakol
--

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[ccp4bb] Postdoc position in Structural Mitochondrial Biology at CPR, University of Copenhagen (Eva Kummer)

[Eva Kummer]

Dear colleagues,

I am excited to announce that a postdoc position will be available in my newly 
established lab at the Novo Nordisk Center for Protein Research (CPR) at 
University Copenhagen. Our group has a deep interest in understanding the 
biology of human mitochondria with a specific focus on how these important 
organelles maintain their DNA and how they produce functional RNA species. In 
this framework, the candidate will investigate membrane protein complexes 
relevant for proper distribution of mitochondrial DNA in the mitochondrial 
network. The primary methodological focus will be on single particle cryo-EM 
with the option for implementing cryo-electron tomography to correlate 
molecular findings with cellular phenotypes.

We are looking for a candidate with strong background in protein biochemistry 
(preferentially of membrane proteins) and cryo-electron microscopy or 
crystallography. Please note that you are also welcome to apply if you are an 
expert in membrane protein biochemistry without structural background but with 
an interest in acquiring cryo-EM expertise. The CPR provides state-of-the-art 
infrastructure and instrumentation including a Titan Krios and a Glacios both 
equipped with Falcon III DED, as well as multiple smaller screening 
instruments. In addition, the center entertains a number of core facilities 
including protein production, crystallography, biophysics, high performance 
computing, mass spectrometry, and genomics. Besides joining an 
interdisciplinary, collaborative and supportive environment, the selected 
candidate can also profit from soft skill courses run by the CPR or the 
University of Copenhagen.

For informal inquiries, please contact me directly: 
eva.kum...@cpr.ku.dk. Applications, however, will 
have to be submitted via the online portal: 
https://employment.ku.dk/faculty/?show=153651

For further information about the lab, please refer to:
https://www.cpr.ku.dk/research/protein-structure-function-program/kummer/

Application deadline is 11 April 2021!

I would appreciate if you could forward this advertisement also to interested 
candidates that may not be part of the mailing list. Thank you!

All the best,
Eva




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