[ccp4bb] postdoctoral positions available
Dear Colleagues, A postdoctoral position is immediately available for a highly motivated individual interested in elucidating molecular mechanisms of ubiquitin signaling and DNA repair. Research is focused on the enzymatic machinery responsible for protein ubiquitination and large protein complexes involved in regulating DNA repair and immunity. These issues will be addressed using a multidisciplinary approach that includes cryo-EM and X-ray crystallography, complemented with biochemical/biophysical techniques and cell-based assays. Successful candidates will join the vibrant scientific community at UT Health San Antonio and enjoy abundant access to state-of-the-art cryo-EM instrumentation including a Glacios TEM equipped with a Falcon 4 direct electron detector and Selectris Imaging Filter that are the centerpiece of our brand new cryo-EM facility. Access to outstanding X-ray crystallography and NMR resources are also available. Candidates should hold a recently obtained PhD in biochemistry, chemistry, or related subject. Demonstrated expertise in cryo-EM is highly desirable, though individuals with expertise in protein chemistry, and/or the biochemical analysis of protein ubiquitination and/or DNA repair will also be considered. Experience with protein expression in insect and mammalian cells is a plus. Recent publications highlighting our research interests: *Structural insights into BCDX2 complex function in homologous recombination [https://www.nature.com/articles/s41586-023-06219-w] *Cryo-EM structures of Uba7 reveal the molecular basis for ISG15 activation and E1-E2 thioester transfer [https://www.nature.com/articles/s41467-023-39780-z] *Crystal structures reveal catalytic and regulatory mechanisms of the dual-specificity ubiquitin/FAT10 E1 enzyme Uba6 [https://www.nature.com/articles/s41467-022-32613-5] *Activity profiling and crystal structures of inhibitor-bound SARS-CoV-2 papain-like protease: A framework for anti-COVID-19 drug design [https://www.science.org/doi/10.1126/sciadv.abd4596] Interested candidates should e-mail a cover letter, CV, and the names of three references to: ols...@uthscsa.edu. Best, -Shaun To unsubscribe from the CCP4BB list, click the following link: https://www.jiscmail.ac.uk/cgi-bin/WA-JISC.exe?SUBED1=CCP4BB=1 This message was issued to members of www.jiscmail.ac.uk/CCP4BB, a mailing list hosted by www.jiscmail.ac.uk, terms & conditions are available at https://www.jiscmail.ac.uk/policyandsecurity/
[ccp4bb] open postodoctoral posiiton
Dear Colleagues, A postdoctoral position is immediately available in the Wasmuth/Olsen Lab for a highly motivated individual interested in elucidating molecular mechanisms of oncogenic nucleoprotein complexes. These issues will be addressed using a multidisciplinary approach that includes cryo-EM, and X-ray crystallography, complemented with biochemistry and cancer biology. Successful candidates will join a vibrant scientific community and enjoy frequent access to state-of-the-art cryo-EM instrumentation including a Glacios TEM equipped with a Falcon 4 direct electron detector and Selectris energy filter that are the centerpiece of our new cryo-EM facility. Ready access to outstanding X-ray crystallography and NMR resources will also be available. Candidates should hold a recently obtained PhD in biochemistry, chemistry, or related subject. Demonstrated expertise in cryo-EM is highly desirable, though individuals with expertise in X-ray crystallography, protein and nucleic acid chemistry, biochemistry, and/or cancer biology will also be considered. Experience with protein expression in insect and mammalian cells is a plus. Interested candidates should e-mail a cover letter, CV, and the names of three references to: wasmu...@uthscsa.edu Elizabeth V. Wasmuth/Shaun K. Olsen Professors of Biochemistry & Structural Biology University of Texas Health Science Center at San Antonio 7703 Floyd Curl Drive, BSB413C/414C San Antonio, TX 78229 E-mail: wasmu...@uthscsa.edu To unsubscribe from the CCP4BB list, click the following link: https://www.jiscmail.ac.uk/cgi-bin/WA-JISC.exe?SUBED1=CCP4BB=1 This message was issued to members of www.jiscmail.ac.uk/CCP4BB, a mailing list hosted by www.jiscmail.ac.uk, terms & conditions are available at https://www.jiscmail.ac.uk/policyandsecurity/
[ccp4bb] Assistant EM Facility Manager Position
Dear Colleagues, The University of Texas Health Science Center at San Antonio is seeking an Assistant Facility Manager for our new cryo-EM facility. The facility is equipped with a Thermo Fisher Scientific, 200kV Glacios TEM, with a Falcon 4 direct electron detector and Selectris Imaging Filter, along with all standard instruments for single particle EM sample preparation. The successful candidate will assist with the day-to-day running of the facility, sample preparation, data collection/processing, and user training. The candidate should be a motivated and highly interactive individual and will have the opportunity to collaborate with internal users and external researchers in cryo-EM-focused research projects. Preferred qualifications: · Must have the ability to assist with management of a multi-user research facility · Must have demonstrated expertise with data collection and processing software for single particle analysis, including Relion and Cryosparc · Previous experience with transmission electron microscope alignments and maintenance, servicing or accessory equipment servicing and maintenance is preferred · Previous experience training students and staff in the operation of transmission electron microscopes and downstream data processing/analysis is preferred · Must be able analyze scientific results/data, communicate effectively with faculty, students, staff, vendors, and service engineers, keep accurate and clear records, actively participate in the planning and writing of center-related grant proposals as needed, keep abreast of scientific literature concerning relevant new instrumentation, data processing, specimen preparation and imaging techniques. · This position provides attractive salary (commensurate with experience and qualifications) and generous benefits. Interested candidates should e-mail a cover letter, CV, and the names of three references to ols...@uthscsa.edu. The position will remain open until filled. Sincerely, Shaun K. Olsen, PhD Associate Professor Department of Biochemistry & Structural Biology UT Health San Antonio San Antonio, TX 78229 ols...@uthscsa.edu To unsubscribe from the CCP4BB list, click the following link: https://www.jiscmail.ac.uk/cgi-bin/WA-JISC.exe?SUBED1=CCP4BB=1 This message was issued to members of www.jiscmail.ac.uk/CCP4BB, a mailing list hosted by www.jiscmail.ac.uk, terms & conditions are available at https://www.jiscmail.ac.uk/policyandsecurity/
[ccp4bb] postdoc position in structural biology
Dear Colleagues, A postdoctoral position is immediately available for a highly motivated individual interested in elucidating molecular mechanisms of ubiquitin signaling. Research is focused on the enzymatic machinery responsible for protein ubiquitination, in particular, large protein complexes involved in regulating DNA repair and immunity. These issues will be addressed using a multidisciplinary approach that includes cryo-EM and X-ray crystallography, complemented with biochemical/biophysical techniques and cell-based assays. Successful candidates will join a vibrant scientific community and enjoy frequent access to state-of-the-art cryo-EM instrumentation including a Glacios TEM equipped with a Falcon 4 direct electron detector and Selectris Imaging Filter that are the centerpiece of our new cryo-EM facility. Access to outstanding X-ray crystallography and NMR resources will also be abundantly available. Candidates should hold a recently obtained PhD in biochemistry, chemistry, or related subject. Demonstrated expertise in cryo-EM is highly desirable, though individuals with expertise in X-ray crystallography, protein chemistry, and/or the biochemical analysis of protein ubiquitination will also be considered. Experience with protein expression in insect and mammalian cells is a plus. Interested candidates should e-mail a cover letter, CV, and the names of three references to: ols...@uthscsa.edu. Shaun K. Olsen Associate Professor Department of Biochemistry & Structural Biology University of Texas Health Science Center at San Antonio 7703 Floyd Curl Drive, BSB413C/414C San Antonio, TX 78229 Phone: 210-450-3091 E-mail: ols...@uthscsa.edu To unsubscribe from the CCP4BB list, click the following link: https://www.jiscmail.ac.uk/cgi-bin/WA-JISC.exe?SUBED1=CCP4BB=1 This message was issued to members of www.jiscmail.ac.uk/CCP4BB, a mailing list hosted by www.jiscmail.ac.uk, terms & conditions are available at https://www.jiscmail.ac.uk/policyandsecurity/
[ccp4bb] postdoc position in structural biology
Dear Colleagues, A postdoctoral position is immediately available for a highly motivated individual interested in understanding molecular mechanisms of ubiquitin signaling. Research is focused on the enzymatic machinery responsible for protein ubiquitination, characterization of PROTAC complexes with potential therapeutic value, and structure determination of large protein complexes involved in ubiquitin signaling, particularly those regulating DNA repair. These issues will be addressed using a multidisciplinary approach that includes cryo-EM, X-ray crystallography, and NMR complemented with biochemical/biophysical techniques and cell-based assays. Candidates should hold a recently obtained PhD in biochemistry, chemistry, or related subject, with demonstrated expertise in cryo-EM, X-ray crystallography, and/or the biochemical analysis of protein ubiquitination. Experience with protein expression in insect and mammalian cells is a plus. Interested candidates should e-mail a cover letter, CV, and the names of three references to: ols...@uthscsa.edu. Shaun K. Olsen Associate Professor Department of Biochemistry & Structural Biology University of Texas Health Science Center at San Antonio 7703 Floyd Curl Drive, BSB413C/414C San Antonio, TX 78229 Phone: 210-450-3091 E-mail: ols...@uthscsa.edu To unsubscribe from the CCP4BB list, click the following link: https://www.jiscmail.ac.uk/cgi-bin/WA-JISC.exe?SUBED1=CCP4BB=1 This message was issued to members of www.jiscmail.ac.uk/CCP4BB, a mailing list hosted by www.jiscmail.ac.uk, terms & conditions are available at https://www.jiscmail.ac.uk/policyandsecurity/
[ccp4bb] Recruiting Cryo EM Facility Manager
Dear Colleagues, The University of Texas Health Science Center at San Antonio is seeking an Assistant/Associate Professor (Research Track) to manage our new cryo-EM facility. The candidate will have the unique opportunity to be involved in development of the facility from its early stages through to a fully operational world-class facility that makes cryo-EM related resources and techniques accessible to investigators at UTHSA. The facility will be equipped with a Thermo Fisher Scientific, 200kV Glacios TEM equipped with a Falcon 4 direct electron detector and Selectris Imaging Filter, along with all standard equipment for single particle EM sample preparation. The successful candidate will be responsible for the day-to-day running of the facility, general lab maintenance/operations, sample preparation, and user training. The candidate should be a motivated and highly interactive individual and will have the opportunity to collaborate with internal users and external researchers in cryo-EM-focused research projects. The candidate will also help support resource development and the development of grant applications. Preferred qualifications: · Must have the ability to manage a multi-user research facility. · Must be able analyze scientific results/data, communicate effectively with faculty, students, staff, vendors, and service engineers, keep accurate and clear records, actively participate in the planning and writing of center-related grant proposals as needed, keep abreast of scientific literature concerning relevant new instrumentation, data processing, specimen preparation and imaging techniques. · Previous experience training students and staff in the operation of transmission electron microscopes and downstream data processing/analysis. · Previous experience with transmission electron microscope alignments and maintenance, servicing or accessory equipment servicing and maintenance. · Expertise with data processing software for single particle analysis, including Relion and Cryosparc. This position provides attractive salary (commensurate with experience and qualifications) and generous benefits. Rank of appointment will be determined based on qualifications and experience. Interested candidates should e-mail a cover letter, CV, and the names of three references to: ols...@uthscsa.edu. Shaun K. Olsen Associate Professor Department of Biochemistry & Structural Biology University of Texas Health Science Center at San Antonio 7703 Floyd Curl Drive, BSB413C/414C San Antonio, TX 78229 Phone: 210-450-3091 To unsubscribe from the CCP4BB list, click the following link: https://www.jiscmail.ac.uk/cgi-bin/WA-JISC.exe?SUBED1=CCP4BB=1 This message was issued to members of www.jiscmail.ac.uk/CCP4BB, a mailing list hosted by www.jiscmail.ac.uk, terms & conditions are available at https://www.jiscmail.ac.uk/policyandsecurity/
[ccp4bb] Postdoctoral position in structural biology
Dear Colleagues, A postdoctoral position is immediately available for a highly motivated individual interested in understanding the structural mechanisms of ubiquitin signaling. Research is focused on understanding basic molecular mechanisms of the enzymatic machinery responsible for protein ubiquitination, structural characterization of PROTAC complexes with potential therapeutic value, and structure determination of large protein complexes regulated by ubiquitin signaling, particularly those involved in DNA repair. These issues will be addressed using a multidisciplinary approach that includes X-ray crystallography and cryoEM complemented with biochemical/biophysical techniques and cell based assays. Candidates should hold a recently obtained PhD in biochemistry, chemistry, or related subject, with demonstrated expertise in X-ray crystallography, cryoEM, and/or the biochemical analysis of protein ubiquitination. Experience with protein expression in insect and mammalian cells is a plus. Interested candidates should e-mail a cover letter, CV, and the names of three references to: ols...@uthscsa.edu. Shaun K. Olsen Associate Professor Department of Biochemistry & Structural Biology University of Texas Health Science Center at San Antonio 7703 Floyd Curl Drive, BSB413C/414C San Antonio, TX 78229 Phone: 210-450-3091 E-mail: ols...@uthscsa.edu To unsubscribe from the CCP4BB list, click the following link: https://www.jiscmail.ac.uk/cgi-bin/WA-JISC.exe?SUBED1=CCP4BB=1 This message was issued to members of www.jiscmail.ac.uk/CCP4BB, a mailing list hosted by www.jiscmail.ac.uk, terms & conditions are available at https://www.jiscmail.ac.uk/policyandsecurity/
[ccp4bb] Postdoctoral position available
Dear Colleagues, A postdoctoral position is available for a highly motivated biochemist/structural biologist interested in studying molecular mechanisms of cell signaling by ubiquitin and ubiquitin-like proteins. Available projects in the laboratory provide excellent training opportunities as they involve a multidisciplinary approach that combines X-ray crystallography, cryo-electron microscopy, biochemical/biophysical techniques, and cell-based assays. Candidates should hold a recently obtained PhD in structural biology, biochemistry, or a related area and should be skilled in standard molecular biology techniques and recombinant protein expression and purification. Candidates with demonstrated expertise in X-ray crystallography and/or single particle cryo-electron microscopy are preferred. Interested candidates should e-mail a cover letter, CV, and the names of three references to olse...@musc.edu. The position will remain open until filled. Best Regards, Shaun K. Olsen, PhD Assistant Professor Dept. of Biochemistry & Molecular Biology Medical University of South Carolina Charleston, SC 29425 olse...@musc.edu To unsubscribe from the CCP4BB list, click the following link: https://www.jiscmail.ac.uk/cgi-bin/webadmin?SUBED1=CCP4BB=1
[ccp4bb] 2 postdoctoral positions- structural biology of ubiquitin signaling
Dear Colleagues, My laboratory is seeking to fill two postdoctoral positions that are immediately available for highly motivated biochemists/structural biologists interested in studying molecular mechanisms of signaling by ubiquitin and ubiquitin-like proteins. Posttranslational modification of proteins by ubiquitin and ubiquitin-like modifiers occurs through the sequential activities of a cascade of enzymes and a major focus of the laboratory is to understand the structural basis by which this enzymatic machinery functions. We address these issues using a multidisciplinary approach that combines X-ray crystallography, biochemical/biophysical techniques, and cell-based studies. Candidates should hold a PhD in a relevant field with demonstrated expertise in X-ray crystallography and/or the biochemical analysis of protein ubiquitination. MUSC is well-equipped for all aspects of X-ray crystallography, including institutional membership of the SER-CAT facility at the Advanced Photon Source. We have a vibrant and growing program in structural biology and work in a highly collaborative environment. The University is located in historic Charleston, SC where the weather is beautiful year-round. There are several beaches within minutes of the city and the mountains are only three hours away. In addition to these amenities, the art, history, food, and festivals make Charleston a fantastic place to work and live. Interested candidates should e-mail a cover letter, CV, and the names of three references to olse...@musc.edu and apply online at http://careers.pageuppeople.com/756/cw/en-us/job/510945/univ-postdoctoral-scholar-biochemistry-molecular-biology. The positions will remain open until filled. Best Regards, -Shaun - Shaun K. Olsen, PhD Assistant Professor Dept. of Biochemistry & Molecular Biology Medical University of South Carolina Charleston, SC 29425 olse...@musc.edu List of Publications-- https://www.ncbi.nlm.nih.gov/myncbi/browse/collection/48468424/?sort=date=descending To unsubscribe from the CCP4BB list, click the following link: https://www.jiscmail.ac.uk/cgi-bin/webadmin?SUBED1=CCP4BB=1
