Evdokimov [EMAIL PROTECTED]
Subject: Re: [ccp4bb] Protein binding to Zn and Ca
To: CCP4BB@JISCMAIL.AC.UK
Concanavalin A can be made to bind Zn and Ca. Its binding site has room for
one transition metal and one alkaline earth metal.
http://www.jbc.org/cgi/content/abstract/271/27/16144
Highly
Hi Neeraj,
a couple of S100 proteins bind Zn2+ and Ca2+. Ca2+ binds to EF-hands;
Zn2+ binds to specific sites distinct of the EF-hands. We are
investigating Zn2+-binding by spectroscopy and crystallography. We think
that Zn2+ is like Ca2+ a kind of second messenger. If you have
questions, I
http://nobelprize.org/nobel_prizes/chemistry/laureates/1946/sumner-lecture.p
df)
Artem
-Original Message-
From: CCP4 bulletin board [mailto:[EMAIL PROTECTED] On Behalf Of Neeraj
Kapoor
Sent: Thursday, June 12, 2008 11:15 PM
To: CCP4BB@JISCMAIL.AC.UK
Subject: [ccp4bb] Protein binding to Zn
Thermolysin binds a catalytic zinc and several Ca ions for structural
stability. See Holland et al. (1995) Protein Sci, 4, 1955.
Hope that helps,
Arthur Glasfeld
Department of Chemistry
Reed College
3203 SE Woodstock Blvd.
Portland, OR 97202
USA
On Jun 12, 2008, at 8:15 PM, Neeraj Kapoor
