[ccp4bb] soaking problem

Dear all, One of my enzymes crystallized in 0.1 M citric acid pH 3.5 and 25% PEK 3350. The structure solution reveals, citrate molecule is occupying the active site. Moreover citrate mediates the dimer formation. I tried crystallization in the same condition with ligand using soaking with

[ccp4bb] citrate blocks the active site

Dear all, One of my enzymes crystallized in 0.1 M citric acid pH 3.5 and 25% PEK 3350. The structure solution reveals, citrate molecule is occupying the active site. Moreover citrate mediates the dimer formation. I tried crystallization in the same condition with ligand using soaking with