Re: [cellml-discussion] CellML 1.1.1 specification

2007-07-19 Thread Alan Garny
  If we had our specification in a version control system and tagged
 out
  releases and release candidates etc, and if we followed a protocol of
  releasing at least one stable minor release that marks depreciation
  only, then the following would be the result (in my mind)
 
  - The current trunk is the development version of cellml 1.2 (i.e.
  unreleased-dev).
  - This current trunk look likes CellML 1.1 and the associated
  definitions in DTDs etc.
  - We update this to mark out that reaction elements are going to be
  depreciated, this includes comments in DTDs etc. We don't remove
  reaction elements from the specification at this stage because that's
  where we hang the depreciation notices.
  - We tag this as 1.1.1 and release it
  - We then delete reaction elements from the specification that is on
 trunk.
 
  Now, this is the kind of process I think covers the steps you have
  been talking about and at the end makes available a trunk version of
  1.2-dev-unreleased that doesn't have reaction elements that people
 can
  check out an play with (this is essentially the proposal page the
  Andrew wrote up - though I think there are issues remaining now with
  the absence of biology from a Cell ML standard.
 
 yep - thats how I would see the specification evolving over time,
 subject, of course, to the various proposals being accepted and
 assigned
 to an appropriate version.
 
 I think the absence of biology from the core specification is probably
 a
 good thing, but there needs to be clear annotation of the specification
 describing how reactions should now be represented in a world without
 reactions - another best practice recommendation and examples in the
 model repository at the least, I would hope.
 
  But what I am also saying is that this is still just an idea, so it
  should be put forward as a proposal that has not been accepted. I.e.
  that the steps I described above are purely hypothetical at the
  moment, since we haven't had the chance to hear arguments from people
  about it - it might turn out to be a silly proposal.
 
 definitely. Your steps describe the process for how the specification
 may be updated, developed, etc., but each release will be the result of
 a set of proposals being accepted and assigned to that particular
 release.
 
 this is why the proposal to remove the reaction element should have
 first been put forward independently of any specific future version of
 CellML. In this discussion forum we could then debate the merits of
 this
 proposal and, if deemed suitable, develop a schedule for the
 implementation of the proposal (i.e., mark reaction element for
 deprecation in 1.1.1 and then remove the reaction element in 1.2).
 Other
 proposals would also be similarly evaluated and possibly assigned to
 the
 same or different releases of the CellML specification.
 
 It definitely should not, at this stage, be a forgone conclusion that
 the reaction element should be removed in 1.2 (or some specific future
 version of CellML) - that is still open to discussion in my mind,
 especially in regard to the tools that biomodels.net are using to
 import/export CellML models with their repository and any other tools
 utilising the reaction element, of which I don't think anyone has yet
 evaluated.

This is also how I see it: CellML 1.1.1 marking reaction element for
deprecation and then CellML 1.2 removing it.

Alan.

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Re: [cellml-discussion] CellML 1.1.1 specification

2007-07-19 Thread James Lawson
David Nickerson wrote:
 Matt wrote:
 It seems there is some misunderstanding as to whether we are discussing
 a proposal to remove the reaction element from CellML or a proposed new
 specification. I thought it was the latter but you seem to be talking
 about the former...

 Both. I think.

 So I will try another explanation.

 If we had our specification in a version control system and tagged out
 releases and release candidates etc, and if we followed a protocol of
 releasing at least one stable minor release that marks depreciation
 only, then the following would be the result (in my mind)

 - The current trunk is the development version of cellml 1.2 (i.e.
 unreleased-dev).
 - This current trunk look likes CellML 1.1 and the associated
 definitions in DTDs etc.
 - We update this to mark out that reaction elements are going to be
 depreciated, this includes comments in DTDs etc. We don't remove
 reaction elements from the specification at this stage because that's
 where we hang the depreciation notices.
 - We tag this as 1.1.1 and release it
 - We then delete reaction elements from the specification that is on trunk.

 Now, this is the kind of process I think covers the steps you have
 been talking about and at the end makes available a trunk version of
 1.2-dev-unreleased that doesn't have reaction elements that people can
 check out an play with (this is essentially the proposal page the
 Andrew wrote up - though I think there are issues remaining now with
 the absence of biology from a Cell ML standard.
 
 yep - thats how I would see the specification evolving over time, 
 subject, of course, to the various proposals being accepted and assigned 
 to an appropriate version.
 
 I think the absence of biology from the core specification is probably a 
 good thing, 

It might be worth adding an editorial comment or similar to note that
the metadata is where the vast majority of biological information is
defined.

but there needs to be clear annotation of the specification
 describing how reactions should now be represented in a world without 
 reactions - another best practice recommendation and examples in the 
 model repository at the least, I would hope.

Yep, the 'signal transduction' tutorial will no longer be needed, since
its main purpose is to describe the best practice for use of reaction
elements to describe biochemical pathways. The question will be, do we
just remove it, or do we create a new tutorial that is biochem specific,
but doesn't talk about reaction elements. For example, there are two
main ways to code up a biochem model: either you can use equations that
describe, for example, the rate of change of conc. of species A, where
species A might have a few different processes acting on it, so this
equation would be a summation of the effect of these processes, OR, you
can split the equation into 'fluxes,' which represent just the effect of
one process on a species at a time. I think it would be worth writing a
best practice guide for writing biochem models, even if it is relatively
short, since there are a few things that are different from how an ephys
model should be coded up.

 
 But what I am also saying is that this is still just an idea, so it
 should be put forward as a proposal that has not been accepted. I.e.
 that the steps I described above are purely hypothetical at the
 moment, since we haven't had the chance to hear arguments from people
 about it - it might turn out to be a silly proposal.
 
 definitely. Your steps describe the process for how the specification 
 may be updated, developed, etc., but each release will be the result of 
 a set of proposals being accepted and assigned to that particular release.
 
 this is why the proposal to remove the reaction element should have 
 first been put forward independently of any specific future version of 
 CellML. 

Perhaps we could start by formalising the actual proposal to get rid of
the rxn element. Why are we doing it? How will we replace the purpose it
served, using metadata for example? I realise that this has been
discussed a lot in an informal manner, and was in fact decided well
before my time, but I guess if we're going to do something as major as
create a new spec version, we should build the foundations first.

In this discussion forum we could then debate the merits of this
 proposal and, if deemed suitable, develop a schedule for the 
 implementation of the proposal (i.e., mark reaction element for 
 deprecation in 1.1.1 and then remove the reaction element in 1.2). Other 
 proposals would also be similarly evaluated and possibly assigned to the 
 same or different releases of the CellML specification.
 
 It definitely should not, at this stage, be a forgone conclusion that 
 the reaction element should be removed in 1.2 (or some specific future 
 version of CellML) - that is still open to discussion in my mind,

It would be good to see a thorough list of pros and cons for the rxn
element.

If we do write a 

Re: [cellml-discussion] CellML 1.1.1 specification

2007-07-19 Thread Matt
More generally I think this issue is tapping on the bigger issue of a
core modelling language and specification, and then special use cases,
of which biological modelling would be a particular case of.

Without reactions, we pretty much have that core language.

My inclination is that biological modelling is a specification of
minimum required annotation of mathematical models using the 'core'
language.

Poul's turn.


On 7/20/07, James Lawson [EMAIL PROTECTED] wrote:
 David Nickerson wrote:
  Matt wrote:
  It seems there is some misunderstanding as to whether we are discussing
  a proposal to remove the reaction element from CellML or a proposed new
  specification. I thought it was the latter but you seem to be talking
  about the former...
 
  Both. I think.
 
  So I will try another explanation.
 
  If we had our specification in a version control system and tagged out
  releases and release candidates etc, and if we followed a protocol of
  releasing at least one stable minor release that marks depreciation
  only, then the following would be the result (in my mind)
 
  - The current trunk is the development version of cellml 1.2 (i.e.
  unreleased-dev).
  - This current trunk look likes CellML 1.1 and the associated
  definitions in DTDs etc.
  - We update this to mark out that reaction elements are going to be
  depreciated, this includes comments in DTDs etc. We don't remove
  reaction elements from the specification at this stage because that's
  where we hang the depreciation notices.
  - We tag this as 1.1.1 and release it
  - We then delete reaction elements from the specification that is on trunk.
 
  Now, this is the kind of process I think covers the steps you have
  been talking about and at the end makes available a trunk version of
  1.2-dev-unreleased that doesn't have reaction elements that people can
  check out an play with (this is essentially the proposal page the
  Andrew wrote up - though I think there are issues remaining now with
  the absence of biology from a Cell ML standard.
 
  yep - thats how I would see the specification evolving over time,
  subject, of course, to the various proposals being accepted and assigned
  to an appropriate version.
 
  I think the absence of biology from the core specification is probably a
  good thing,

 It might be worth adding an editorial comment or similar to note that
 the metadata is where the vast majority of biological information is
 defined.

 but there needs to be clear annotation of the specification
  describing how reactions should now be represented in a world without
  reactions - another best practice recommendation and examples in the
  model repository at the least, I would hope.

 Yep, the 'signal transduction' tutorial will no longer be needed, since
 its main purpose is to describe the best practice for use of reaction
 elements to describe biochemical pathways. The question will be, do we
 just remove it, or do we create a new tutorial that is biochem specific,
 but doesn't talk about reaction elements. For example, there are two
 main ways to code up a biochem model: either you can use equations that
 describe, for example, the rate of change of conc. of species A, where
 species A might have a few different processes acting on it, so this
 equation would be a summation of the effect of these processes, OR, you
 can split the equation into 'fluxes,' which represent just the effect of
 one process on a species at a time. I think it would be worth writing a
 best practice guide for writing biochem models, even if it is relatively
 short, since there are a few things that are different from how an ephys
 model should be coded up.

 
  But what I am also saying is that this is still just an idea, so it
  should be put forward as a proposal that has not been accepted. I.e.
  that the steps I described above are purely hypothetical at the
  moment, since we haven't had the chance to hear arguments from people
  about it - it might turn out to be a silly proposal.
 
  definitely. Your steps describe the process for how the specification
  may be updated, developed, etc., but each release will be the result of
  a set of proposals being accepted and assigned to that particular release.
 
  this is why the proposal to remove the reaction element should have
  first been put forward independently of any specific future version of
  CellML.

 Perhaps we could start by formalising the actual proposal to get rid of
 the rxn element. Why are we doing it? How will we replace the purpose it
 served, using metadata for example? I realise that this has been
 discussed a lot in an informal manner, and was in fact decided well
 before my time, but I guess if we're going to do something as major as
 create a new spec version, we should build the foundations first.

 In this discussion forum we could then debate the merits of this
  proposal and, if deemed suitable, develop a schedule for the
  implementation of the proposal (i.e., mark 

[cellml-discussion] CellML 1.1.1 specification

2007-07-18 Thread Andrew Miller
David Nickerson wrote:
 Andrew Miller wrote:
   
 David Nickerson wrote:
 
 From what I gather, publicity. We need some way to direct people's
 attention to our intention to deprecate reaction elements.
 
 
 sure - but its still not clear to me if 1.1.1 is making clear our 
 intention to deprecate reaction elements or if it is making reaction 
 elements invalid in a 1.1.1 version model?
   
   
 I think that both are true:
 1) Reaction elements would be invalid in the 1.1.1 specification I proposed.
 2) Versions of CellML earlier than 1.1.1 would be deprecated by virtue 
 of the fact that they are no longer the latest version of CellML, and 
 therefore reaction elements are deprecated.
 

 but neither of these address our intention to deprecate the reaction 
 element.
   

I don't really understand what you are trying to say. How does releasing 
a new version which does not contain the reaction element not show an 
intention that the reaction element be deprecated)?

   
 I think that people who look at CellML at present are not sufficiently 
 discouraged from using reaction elements, and I agree that a new version 
 is reasonable to publicise what we as a community think is the proper 
 direction for CellML.
 

 just to reiterate, when raising the issue of marking the reaction 
 element for deprecation in the final 1.1 specification the decision was 
 made to not do so and at the time it was also decided that the next 
 version of cellml would be the one to formally mark the reaction element 
 for deprecation. If this decision has been revisited and found in error, 
 then the errata for the 1.1 specification should be updated to reflect that.
   

Errata are primarily there to correct errors in the specification, not 
errors in the process by which the specification arose, or to make 
substantive changes to the specification.

Correct me if I am wrong, but I believe that nothing in the text of the 
CellML 1.1 specification says that reactions will or will not be 
deprecated in any future version of CellML, and therefore there is no 
need for an erratum to CellML 1.1 (and indeed, such an erratum would be 
inappropriate).

Best regards,
Andrew

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Re: [cellml-discussion] CellML 1.1.1 specification

2007-07-18 Thread Andrew Miller
David Nickerson wrote:
 Correct me if I am wrong, but I believe that nothing in the text of the 
 CellML 1.1 specification says that reactions will or will not be 
 deprecated in any future version of CellML, and therefore there is no 
 need for an erratum to CellML 1.1 (and indeed, such an erratum would be 
 inappropriate).
 

 exactly, and as a core element with an entire top level section of the 
 1.0 and 1.1 specifications devoted to it and with no annotation to state 
 that it is not going to be around much longer it is reasonable to expect 
 that the reaction element will remain in the next version of the 
 specification.

 To have the reaction element go from a significant core element in 1.0 
 and 1.1 to obsolete in 1.1.1 with no formal deprecation step just seems 
 wrong to me - maybe I'm the only one that sees any problems here?

 While the reaction element is obviously one that we want to get rid of, 
 what kind of precedence are we setting for the evolution of CellML by 
 simply deleting it with nothing more formal than saying its about time 
 we tidied up that mess?
   
Hi Andre,

I think that we disagree about how the specification process should work 
and what it aims to address. I see a given version of a CellML 
specification as being a 'protocol' which both tools and model authors 
speak, therefore allowing them to interwork.

In my view, it is inappropriate for specifications to act like either 
tutorials or newsletters (a small amount of such editorial material may 
be appropriate and useful in some cases, but it should not detract from 
the primary goal of the specification, which is to provide a normative 
definition of that particular version of CellML).

Tools are encouraged to process multiple versions of CellML (section 4.1 
of RFC4708 http://www.rfc-editor.org/rfc/rfc4708.txt says that  As 
efforts are made to keep the number of specific formats small, user 
agents SHOULD implement all specific formats listed in the CellML 
Umbrella Format Registry at the time they were developed.). Therefore, 
tools will continue to support reaction elements for as long as they 
decide they want to support CellML 1.1 (and 1.0).

I  think that deleting things from newer specifications is common, and 
indeed, the IETF process, which has given rise to most good quality 
protocols in use on the Internet today, calls for unused features to be 
deleted prior to something becoming a draft standard: section 4.1.2 of 
RFC2026 http://www.rfc-editor.org/rfc/rfc2026.txt


   The requirement for at least two independent and interoperable
   implementations applies to all of the options and features of the
   specification.  In cases in which one or more options or features
   have not been demonstrated in at least two interoperable
   implementations, the specification may advance to the Draft Standard
   level only if those options or features are removed.



If IETF believes that it is okay to remove features simply be removed 
because they have never been implemented, then certainly we should at 
least allow them to be removed if they are not only poorly implemented 
but also a bad fit conceptually.

Best regards,
Andrew

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