On Wed, 2021-09-01 at 16:55 -0700, Seth Harris wrote:
> Hi all,
Hi Seth,
> I am increasingly dealing with large macrocycles or cyclized peptides that
> include unnatural amino acids or
> modifications. Early on my approach was to treat most of it as the native
> peptide scaffold, then add a
Hi Seth,
There might be a more straight-forward way, but here is what I would do:
- modify a native amino acid to your non-natural residue i.e. in Jligand
- assign a new three-letter code and write it out as cif and PDB file
- open the cif file in your favorite text editor and define it as
Hi all,
I am increasingly dealing with large macrocycles or cyclized peptides that
include unnatural amino acids or modifications. Early on my approach was to
treat most of it as the native peptide scaffold, then add a few custom
'LINK' records to capture covalent bonds to some non-native moiety,
