Thank you so much for sharing this wonderful news. It will be very useful.
El viernes, 2 de junio de 2023, Matthew Fidler
escribió:
> The nlmixr2/rxode2 team is excited to announce a tool to help conversion
> of NONMEM to rxode2 or nlmixr2 fits with nonmem2rx and babelmixr2.
>
> With
t; > Executive Director
> >
> > Pharmacokinetics, Modeling, and Simulation (PKMS)
> >
> > Clinical Pharmacology and Exploratory Development (CPED)
> >
> > Astellas
> >
> > 1 Astellas Way
> >
> > Northbrook, IL 60062
> >
> > pe
Dear nmusers,
I'm working on the population PK of a therapeutic peptide candidate for
rheumatoid arthritis. Three dose levels of the peptide were administered as
a single subcutaneous injection.
We have some limitations, for instance, the dataset is very sparse and is
lacking in the information
r record so CL(TIME) is constant
>> between records, while in the DES block T (time) changes continuously,
>> thus implementing time dependence CL(T) exactly rather than
>> approximately. The rest is fine.
>> Thanks
>> Leonid
>>
>> On 7/22/2021 4:19 PM, Niury
2*EXP(-KDES*T)
> CL_TOTAL = CL2_TIME + CL1 ; total clearance
> ...
>
> Thanks
> Leonid
>
>
> On 7/22/2021 3:30 PM, Niurys.CS wrote:
>
>> Dear nmusers,
>> I'm working on the pharmacokinetics of an antiCD20 mAb; I suspect the
>> clearance of this mAb sho
Dear nmusers,
I'm working on the pharmacokinetics of an antiCD20 mAb; I suspect the
clearance of this mAb should be time dependent as rituximab’s clearance do.
I tried to model this behavior but I’m not sure if the ODEs are correct.
Please can you help? I share part of the code.
$SUBROUTINE
u know why the math book was sad?
> Answer: Because it had so many problems
>
>
> -Original Message-
> From: Leonid Gibiansky
> Sent: Thursday, April 29, 2021 11:42 AM
> To: Justin Wilkins ; Bill Denney <
> wden...@humanpredictions.com>; Bonate, Peter ;
> Niurys.CS
> Cc:
e
> washout time. During this time, concentrations drop approximately 2^5=32
> times. So one can simulate the desired dosing (single dose or steady
> state), find the time from Cmax to Cmax/32 and call it washout time (or
> time to Cmax/64 to be conservative)
>
> Thanks
> Leonid
>
>
Dear all
I need some help to assess the elimination half life of a monoclonal
antibody.
The model that describes the data is a QSS aproximation of TMDD with Rmax
constant. The model includes two binding process of mAb to its target: in
central and peripheral compartments.
Is there any specific
Dear Wenping and nlmixr team,
Thanks for sharing with us your work!!!
Hugs,
Niurys
giving more info will help. (What tool are you using
> for bootstrap? What command line are you running? Can you share the model
> and a snippet of the data?)
>
> Thanks,
>
> Bill
>
> -----Original Message-
> From: owner-nmus...@globomaxnm.com On Behalf
> O
Dear nmusers,
I have a big doubt. When I used the bootstrap to evaluate my model, I
had some bugs. In my code I use IGNORE statements based on FLAGS for
some outliers. I don't know if I remove these IGNORE statements, the
bootstrap will run well. Can you give me some suggestions???
Regards
This part of
> the code was not shown, and it depends on the assay (for QSS part of the
> model).
>
> Thanks
> Leonid
>
>
> On 4/23/2019 8:34 AM, Niurys.CS wrote:
>> Dear All,
>>
>> I'm working on the population pharmacokinetics of a mAb, in this study
>
Dear All,
I'm working on the population pharmacokinetics of a mAb, in this study
4 dose levels (50, 100, 200 and 400 mg) were evaluated. I tested
different models, but none of them fit well; that's why I decided to
find for each dose level the best model. I found the two lower dose
levels fitted
Dear All,
I'm working on the population pharmacokinetics of a mAb, in this study
4 dose levels (50, 100, 200 and 400 mg) were evaluated. I tested
different models, but none of them fit well; that's why I decided to
find for each dose level the best model. I found the two lower dose
levels fitted
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