.
Best,
Ken
-Original Message-
From: owner-nmus...@globomaxnm.com [mailto:owner-nmus...@globomaxnm.com] On
Behalf Of Nick Holford
Sent: Tuesday, June 2, 2020 3:46 PM
To: nmusers@globomaxnm.com
Subject: RE: [NMusers] Negative concentration from simulation
Hi Nyein,
For drug
---
From: owner-nmus...@globomaxnm.com On Behalf Of
Bill Denney
Sent: Tuesday, June 2, 2020 2:30 PM
To: Nyein Hsu Maung ; nmusers@globomaxnm.com
Subject: [EXTERNAL] RE: [NMusers] Negative concentration from simulation
Hi Nyein,
Negative concentrations can be expected from simulations if the model include
2020 8:30 PM
To: Nyein Hsu Maung ; nmusers@globomaxnm.com
Subject: RE: [NMusers] Negative concentration from simulation
Hi Nyein,
Negative concentrations can be expected from simulations if the model includes additive
residual error. I assume that you mean additive and proportional
Of
Bill Denney
Sent: Tuesday, June 2, 2020 2:30 PM
To: Nyein Hsu Maung ; nmusers@globomaxnm.com
Subject: [EXTERNAL] RE: [NMusers] Negative concentration from simulation
Hi Nyein,
Negative concentrations can be expected from simulations if the model includes
additive residual error. I assume
the question, answer the question, attempt all questions
-Original Message-
From: owner-nmus...@globomaxnm.com On Behalf Of
Bill Denney
Sent: Tuesday, 2 June 2020 8:30 PM
To: Nyein Hsu Maung ; nmusers@globomaxnm.com
Subject: RE: [NMusers] Negative concentration from simulation
Hi Nyei
Hi Nyein,
Negative concentrations can be expected from simulations if the model
includes additive residual error. I assume that you mean additive and
proportional error when you say "combined error model". If the error
structure does not include additive error, then we'd need to know more.
How
you can treat it as any other value below quantification limit, and
either comment it out (if you do this with other BQLs) or use it (same
as other BQLs)
Leonid
On 6/2/2020 2:13 PM, Nyein Hsu Maung wrote:
Dear NONMEM users,
I tried to simulate a new dataset by using a previously published
