My guess is the low response is likely an effect of inexperienced and
intermediate users remaining silent to allow the most informed users
decide the outcome of the poll. This was a consideration for me, even
though I eventually decided to participate as an intermediate user.
Regular reading of a
Dear all,
I have trouble modeling some rat PK data obtained after intravenous
dosing. I have dense data for two different doses, given either as bolus,
half-hour or 3-hour infusion. We know that the compound has a large
binding affinity to intracellular structures and therefore has a high
Nele
It is possible to simulate
AUC_iv_bolus = 3*AUC_3h_inf
This was done using the code below, assuming a saturation in both
elimination and distribution in the peripheral compartment (similar to the
pharmacokinetics of taxol)
The problem is that the AUC_0.5h_inf is intermediate and closer to
Dear,
This can most likely be described by a model of non-instantaneous and
potentially irreversible binding kinetics to the intracellular
proteins/structures.
With bolus, you see the drug in plasma (hence higher AUC) before it binds to
the internal proteins irreversably.
With infusions, more of
Dear Sam and Ayyappa,
The postings that Sam mentioned are obsolete.
The first of the model time examples (help mtime) suggests a
better technique for modelling EHC using MTIME parameters, as follows:
Enterohepatic Recycling
This fragment of abbreviated code may be used to model EHC.
Dear Alison:
Thanks for let us know this new feature in nm 6. I have been working on
EHC modeling for single dose as well as multiple dose pk data. I have
some questions on how to use this new feature.
How do we define the FLAG when we also have MTIME(3), MTIME(4), MTIME(5)
and MTIME(6)? We
Dear NONMEM community,
Due to a mistake on my part I recently executed a NONMEM job with the
Laplacian estimation method and calculation of the second derivatives turned
off ($ABBREVIATED DERIV2=NO). This is according to the NONMEM users guide
and common sense about the estimation method an
Martin,
It has been a while, but my recollection is that NONMEM is computing the
second derivatives numerically when you supply LAPLACE and $ABBREVIATED
DERIV2=NO. I think NONMEM supplies this option automatically in just this
case. You might test this by using the above with NONUMERICAL on
Martin,
I was just talking to Ken. And we thought that perhaps the report file
would state that NUMERICAL was used in this case. You might look there as
well.
Cheers,
Matt
From: [EMAIL PROTECTED] [mailto:[EMAIL PROTECTED] On
Behalf Of Matt Hutmacher
Sent: Thursday, December 04, 2008
Dear Sam and others,
I prefer to be a lurker on this email list. I'd rather
not be drawn into a lengthy discussion ...!
To answer your question, it might look something like this:
$PK (NON-EVENT)
MTIME(1)=THETA(8) ; start of change due to meal #1
MTIME(2)=MTIME(1)+THETA(9) ; end
Dear all,
I am working on modelling prednisone and prednisolone PPK in humans given a PO
dose of prednisone. Note that prednisone is converted to prednisolone during
the first-pass and prednisolone is converted back to prednisone (reversible
metabolism). I used a simple 2-cmt PK model (see
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